Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Monoallelic intragenic POU3F2 variants lead to neurodevelopmental delay and hyperphagic obesity, confirming the gene's candidacy in 6q16.1 deletions.

Schönauer, Ria; Jin, Wenjun; Findeisen, Christin; Valenzuela, Irene; Devlin, Laura Alice; Murrell, Jill; Bedoukian, Emma C; Pöschla, Linda; Hantmann, Elena; Riedhammer, Korbinian M; Hoefele, Julia; Platzer, Konrad; Biemann, Ronald; Campeau, Philipp M; Münch, Johannes; Heyne, Henrike; Hoffmann, Anne; Ghosh, Adhideb; Sun, Wenfei; Dong, Hua; Noé, Falko; Wolfrum, Christian; Woods, Emily; Parker, Michael J; Neatu, Ruxandra; Le Guyader, Gwenael; Bruel, Ange-Line; Perrin, Laurence; Spiewak, Helena; Missotte, Isabelle; Fourgeaud, Melanie; Michaud, Vincent; Lacombe, Didier; Paolucci, Sarah A; Buchan, Jillian G; Glissmeyer, Margaret; Popp, Bernt; Blüher, Matthias; Sayer, John A; Halbritter, Jan.

Am J Hum Genet ; 110(6): 998-1007, 2023 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-37207645

2.

Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.

Dalmas, Elise; Lehmann, Frank M; Dror, Erez; Wueest, Stephan; Thienel, Constanze; Borsigova, Marcela; Stawiski, Marc; Traunecker, Emmanuel; Lucchini, Fabrizio C; Dapito, Dianne H; Kallert, Sandra M; Guigas, Bruno; Pattou, Francois; Kerr-Conte, Julie; Maechler, Pierre; Girard, Jean-Philippe; Konrad, Daniel; Wolfrum, Christian; Böni-Schnetzler, Marianne; Finke, Daniela; Donath, Marc Y.

Immunity ; 47(5): 928-942.e7, 2017 11 21.

Artigo em Inglês | MEDLINE | ID: mdl-29166590

3.

snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis.

Sun, Wenfei; Dong, Hua; Balaz, Miroslav; Slyper, Michal; Drokhlyansky, Eugene; Colleluori, Georgia; Giordano, Antonio; Kovanicova, Zuzana; Stefanicka, Patrik; Balazova, Lucia; Ding, Lianggong; Husted, Anna Sofie; Rudofsky, Gottfried; Ukropec, Jozef; Cinti, Saverio; Schwartz, Thue W; Regev, Aviv; Wolfrum, Christian.

Nature ; 587(7832): 98-102, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-33116305

4.

Metabolic reconstitution of germ-free mice by a gnotobiotic microbiota varies over the circadian cycle.

Hoces, Daniel; Lan, Jiayi; Sun, Wenfei; Geiser, Tobias; Stäubli, Melanie L; Cappio Barazzone, Elisa; Arnoldini, Markus; Challa, Tenagne D; Klug, Manuel; Kellenberger, Alexandra; Nowok, Sven; Faccin, Erica; Macpherson, Andrew J; Stecher, Bärbel; Sunagawa, Shinichi; Zenobi, Renato; Hardt, Wolf-Dietrich; Wolfrum, Christian; Slack, Emma.

PLoS Biol ; 20(9): e3001743, 2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-36126044

5.

The obesity-linked human lncRNA AATBC stimulates mitochondrial function in adipocytes.

Giroud, Maude; Kotschi, Stefan; Kwon, Yun; Le Thuc, Ophélia; Hoffmann, Anne; Gil-Lozano, Manuel; Karbiener, Michael; Higareda-Almaraz, Juan Carlos; Khani, Sajjad; Tews, Daniel; Fischer-Posovszky, Pamela; Sun, Wenfei; Dong, Hua; Ghosh, Adhideb; Wolfrum, Christian; Wabitsch, Martin; Virtanen, Kirsi A; Blüher, Matthias; Nielsen, Søren; Zeigerer, Anja; García-Cáceres, Cristina; Scheideler, Marcel; Herzig, Stephan; Bartelt, Alexander.

EMBO Rep ; 24(10): e57600, 2023 Oct 09.

Artigo em Inglês | MEDLINE | ID: mdl-37671834

6.

A stromal cell population that inhibits adipogenesis in mammalian fat depots.

Schwalie, Petra C; Dong, Hua; Zachara, Magda; Russeil, Julie; Alpern, Daniel; Akchiche, Nassila; Caprara, Christian; Sun, Wenfei; Schlaudraff, Kai-Uwe; Soldati, Gianni; Wolfrum, Christian; Deplancke, Bart.

Nature ; 559(7712): 103-108, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29925944

7.

Local acetate inhibits brown adipose tissue function.

Sun, Wenfei; Dong, Hua; Wolfrum, Christian.

Proc Natl Acad Sci U S A ; 118(49)2021 12 07.

Artigo em Inglês | MEDLINE | ID: mdl-34845033

8.

FGF-2-dependent signaling activated in aged human skeletal muscle promotes intramuscular adipogenesis.

Mathes, Sebastian; Fahrner, Alexandra; Ghoshdastider, Umesh; Rüdiger, Hannes A; Leunig, Michael; Wolfrum, Christian; Krützfeldt, Jan.

Proc Natl Acad Sci U S A ; 118(37)2021 09 14.

Artigo em Inglês | MEDLINE | ID: mdl-34493647

9.

Enantioselective Total Syntheses of Cassane Furanoditerpenoids and Their Stimulation of Cellular Respiration in Brown Adipocytes.

Bulthaupt, Hendrik H; Glatz, Fabian; Papidocha, Sven M; Wu, Chunyan; Teh, Shawn; Wolfrum, Susanne; Balázová, Lucia; Wolfrum, Christian; Carreira, Erick M.

J Am Chem Soc ; 145(39): 21562-21568, 2023 10 04.

Artigo em Inglês | MEDLINE | ID: mdl-37751294

10.

A 'replace me' signal from dying brown fat fires up weight loss.

De Bock, Katrien; Wolfrum, Christian.

Nature ; 609(7926): 252-253, 2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-35821410

11.

Adipose-derived circulating miRNAs regulate gene expression in other tissues.

Thomou, Thomas; Mori, Marcelo A; Dreyfuss, Jonathan M; Konishi, Masahiro; Sakaguchi, Masaji; Wolfrum, Christian; Rao, Tata Nageswara; Winnay, Jonathon N; Garcia-Martin, Ruben; Grinspoon, Steven K; Gorden, Phillip; Kahn, C Ronald.

Nature ; 542(7642): 450-455, 2017 02 23.

Artigo em Inglês | MEDLINE | ID: mdl-28199304

12.

The Role of IL-13 and IL-4 in Adipose Tissue Fibrosis.

Arndt, Lilli; Lindhorst, Andreas; Neugebauer, Julia; Hoffmann, Anne; Hobusch, Constance; Alexaki, Vasileia-Ismini; Ghosh, Adhideb; Blüher, Matthias; Wolfrum, Christian; Glaß, Markus; Gericke, Martin.

Int J Mol Sci ; 24(6)2023 Mar 16.

Artigo em Inglês | MEDLINE | ID: mdl-36982747

13.

Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue.

Meen, Astri J; Doncheva, Atanaska I; Böttcher, Yvonne; Dankel, Simon N; Hoffmann, Anne; Blüher, Matthias; Fernø, Johan; Mellgren, Gunnar; Ghosh, Adhideb; Sun, Wenfei; Dong, Hua; Noé, Falko; Wolfrum, Christian; Pejler, Gunnar; Dalen, Knut Tomas; Kolset, Svein O.

Int J Mol Sci ; 24(8)2023 Apr 07.

Artigo em Inglês | MEDLINE | ID: mdl-37108048

14.

Novel insights into adipose tissue heterogeneity.

Wang, Tongtong; Sharma, Anand Kumar; Wolfrum, Christian.

Rev Endocr Metab Disord ; 23(1): 5-12, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-34935088

15.

Maternal overnutrition programs hedonic and metabolic phenotypes across generations through sperm tsRNAs.

Sarker, Gitalee; Sun, Wenfei; Rosenkranz, David; Pelczar, Pawel; Opitz, Lennart; Efthymiou, Vissarion; Wolfrum, Christian; Peleg-Raibstein, Daria.

Proc Natl Acad Sci U S A ; 116(21): 10547-10556, 2019 05 21.

Artigo em Inglês | MEDLINE | ID: mdl-31061112

16.

Relation of diet-induced thermogenesis to brown adipose tissue activity in healthy men.

Loeliger, Rahel Catherina; Maushart, Claudia Irene; Gashi, Gani; Senn, Jaël Rut; Felder, Martina; Becker, Anton S; Müller, Julian; Balaz, Miroslav; Wolfrum, Christian; Burger, Irene A; Betz, Matthias Johannes.

Am J Physiol Endocrinol Metab ; 320(1): E93-E101, 2021 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-33225717

17.

High-Throughput Single-Cell Mass Spectrometry Reveals Abnormal Lipid Metabolism in Pancreatic Ductal Adenocarcinoma.

Liu, Qinlei; Ge, Wenjie; Wang, Tongtong; Lan, Jiayi; Martínez-Jarquín, Sandra; Wolfrum, Christian; Stoffel, Markus; Zenobi, Renato.

Angew Chem Int Ed Engl ; 60(46): 24534-24542, 2021 11 08.

Artigo em Inglês | MEDLINE | ID: mdl-34505339

18.

Fat cells with a sweet tooth.

Sun, Wenfei; Wolfrum, Christian.

Nature ; 565(7738): 167-168, 2019 01.

Artigo em Inglês | MEDLINE | ID: mdl-30622347

19.

Antioxidants protect against diabetes by improving glucose homeostasis in mouse models of inducible insulin resistance and obesity.

Straub, Leon G; Efthymiou, Vissarion; Grandl, Gerald; Balaz, Miroslav; Challa, Tenagne Delessa; Truscello, Luca; Horvath, Carla; Moser, Caroline; Rachamin, Yael; Arnold, Myrtha; Sun, Wenfei; Modica, Salvatore; Wolfrum, Christian.

Diabetologia ; 62(11): 2094-2105, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31309261

20.

Identification of chemotypes in bitter melon by metabolomics: a plant with potential benefit for management of diabetes in traditional Chinese medicine.

Zhou, Shuaizhen; Allard, Pierre-Marie; Wolfrum, Christian; Ke, Changqiang; Tang, Chunping; Ye, Yang; Wolfender, Jean-Luc.

Metabolomics ; 15(8): 104, 2019 07 18.

Artigo em Inglês | MEDLINE | ID: mdl-31321563

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