Detalhe da pesquisa
1.
Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder.
Bioorg Med Chem Lett
; 21(18): 5436-41, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21782428
2.
The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.
J Pharmacol Exp Ther
; 328(3): 900-11, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19098165
3.
Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists Part 1. The discovery of arylacetamides as viable replacements for the dihydropyrimidinone moiety of an HTS hit.
J Med Chem
; 50(16): 3870-82, 2007 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-17668921
4.
Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits.
J Med Chem
; 50(16): 3883-90, 2007 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-17668922
5.
Positive modulation of δ-subunit containing GABA(A) receptors in mouse neurons.
Neuropharmacology
; 63(3): 469-79, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22579928
6.
The effects of stressful stimuli and hypothalamic-pituitary-adrenal axis activation are reversed by the melanin-concentrating hormone 1 receptor antagonist SNAP 94847 in rodents.
Behav Brain Res
; 197(2): 284-91, 2009 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18793675
7.
Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299.
Proc Natl Acad Sci U S A
; 102(48): 17489-94, 2005 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16287967