Detalhe da pesquisa
1.
Assessment of inhalation toxicity of cigarette smoke and aerosols from flavor mixtures: 5-week study in A/J mice.
J Appl Toxicol
; 42(10): 1701-1722, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35543240
2.
A 6-month inhalation toxicology study in Apoe-/- mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract.
Arch Toxicol
; 95(5): 1805-1829, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33963423
3.
Impact of whole-body versus nose-only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2-month cigarette smoke exposure study in the ApoE-/- mouse model.
J Appl Toxicol
; 41(10): 1598-1619, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33825214
4.
A 6-month systems toxicology inhalation study in ApoE-/- mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared with cigarette smoke.
Am J Physiol Heart Circ Physiol
; 318(3): H604-H631, 2020 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31975625
5.
E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE-/- mouse model.
Arch Toxicol
; 94(6): 2163-2177, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32409933
6.
ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.
Mol Cell
; 40(1): 75-86, 2010 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20932476
7.
Evaluation of the Tobacco Heating System 2.2 (THS2.2). Part 5: microRNA expression from a 90-day rat inhalation study indicates that exposure to THS2.2 aerosol causes reduced effects on lung tissue compared with cigarette smoke.
Regul Toxicol Pharmacol
; 81 Suppl 2: S82-S92, 2016 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-27866933
8.
Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke.
Regul Toxicol Pharmacol
; 81 Suppl 2: S59-S81, 2016 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-27793746
9.
Deconvolution of Systemic Pharmacokinetics Predicts Inhaled Aerosol Dosimetry of Nicotine.
Eur J Pharm Sci
; 180: 106321, 2023 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36336278
10.
Discriminating Spontaneous From Cigarette Smoke and THS 2.2 Aerosol Exposure-Related Proliferative Lung Lesions in A/J Mice by Using Gene Expression and Mutation Spectrum Data.
Front Toxicol
; 3: 634035, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-35295134
11.
Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke.
Toxicol Sci
; 178(1): 44-70, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32780830
12.
Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case.
Toxicol Rep
; 7: 1187-1206, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32995294
13.
Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice.
Toxicol Sci
; 178(1): 138-158, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32780831
14.
Roles of NF-kappaB in health and disease: mechanisms and therapeutic potential.
Clin Sci (Lond)
; 116(6): 451-65, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19200055
15.
Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange.
Nucleic Acids Res
; 33(17): e147, 2005 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-16204450
16.
Therapeutic strategies for hepatitis B virus-associated hepatocellular carcinoma.
Curr Drug Targets
; 3(5): 369-78, 2002 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12182228
17.
A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time.
Cell Rep
; 9(5): 1946-1958, 2014 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25464845
18.
NUCKS is a positive transcriptional regulator of insulin signaling.
Cell Rep
; 7(6): 1876-86, 2014 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24931609
19.
The POPX2 phosphatase regulates cancer cell motility and invasiveness.
Cell Cycle
; 9(1): 179-87, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20016286
20.
Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression.
Nat Cell Biol
; 12(8): 758-67, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20622870