Detalhe da pesquisa
1.
Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds-synthesis, biological activity, and structural evaluation.
J Enzyme Inhib Med Chem
; 38(1): 2209828, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37184096
2.
Synthesis, Structural and Behavioral Studies of Indole Derivatives D2AAK5, D2AAK6 and D2AAK7 as Serotonin 5-HT1A and 5-HT2A Receptor Ligands.
Molecules
; 28(1)2023 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36615578
3.
Development and Characterization of Novel Selective, Non-Basic Dopamine D2 Receptor Antagonists for the Treatment of Schizophrenia.
Molecules
; 28(10)2023 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37241951
4.
Allosteric Modulators of Dopamine D2 Receptors for Fine-Tuning of Dopaminergic Neurotransmission in CNS Diseases: Overview, Pharmacology, Structural Aspects and Synthesis.
Molecules
; 28(1)2022 Dec 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36615372
5.
Methods of Lysergic Acid Synthesis-The Key Ergot Alkaloid.
Molecules
; 27(21)2022 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36364148
6.
Experimental and Computational Structural Studies of 2,3,5-Trisubstituted and 1,2,3,5-Tetrasubstituted Indoles as Non-Competitive Antagonists of GluK1/GluK2 Receptors.
Molecules
; 27(8)2022 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35458681
7.
Discovery of Novel Non-Steroidal Cytochrome P450 17A1 Inhibitors as Potential Prostate Cancer Agents.
Int J Mol Sci
; 21(14)2020 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32660148
8.
The Antipsychotic D2AAK1 as a Memory Enhancer for Treatment of Mental and Neurodegenerative Diseases.
Int J Mol Sci
; 21(22)2020 Nov 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33238370
9.
Synthesis, Structural and Thermal Studies of 3-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-ethoxy-1H-indole (D2AAK1_3) as Dopamine D2 Receptor Ligand.
Molecules
; 23(9)2018 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30181442
10.
Discovery of nitroaryl urea derivatives with antiproliferative properties.
J Enzyme Inhib Med Chem
; 31(4): 608-18, 2016 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26114307
11.
Synthesis, Structural Studies and Molecular Modelling of a Novel Imidazoline Derivative with Antifungal Activity.
Molecules
; 20(8): 14761-76, 2015 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26287137
12.
Synthesis, in vitro and in vivo studies, and molecular modeling of N-alkylated dextromethorphan derivatives as non-competitive inhibitors of α3ß4 nicotinic acetylcholine receptor.
Bioorg Med Chem
; 22(24): 6846-56, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25464883
13.
Discovery and inâ vitro Evaluation of Novel Serotonin 5-HT2A Receptor Ligands Identified Through Virtual Screening.
ChemMedChem
; : e202400080, 2024 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38619283
14.
A comprehensive assessment of palmatine as anticonvulsant agent - In vivo and in silico studies.
Biomed Pharmacother
; 172: 116234, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38325264
15.
Non-steroidal CYP17A1 Inhibitors: Discovery and Assessment.
J Med Chem
; 66(10): 6542-6566, 2023 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37191389
16.
Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis.
Biomolecules
; 13(9)2023 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37759751
17.
Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents - Design, synthesis, structural studies and pharmacological profiling.
Eur J Med Chem
; 252: 115285, 2023 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37027998
18.
Allosteric modulation of dopamine D2L receptor in complex with Gi1 and Gi2 proteins: the effect of subtle structural and stereochemical ligand modifications.
Pharmacol Rep
; 74(2): 406-424, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35064921
19.
Multitarget Derivatives of D2AAK1 as Potential Antipsychotics: The Effect of Substitution in the Indole Moiety.
ChemMedChem
; 17(15): e202200238, 2022 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35610178
20.
WaterMap-Guided Structure-Based Virtual Screening for Acetylcholinesterase Inhibitors.
ChemMedChem
; 17(8): e202100721, 2022 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35157366