Detalhe da pesquisa
1.
Differential activity of mGlu7 allosteric modulators provides evidence for mGlu7/8 heterodimers at hippocampal Schaffer collateral-CA1 synapses.
J Biol Chem
; 298(10): 102458, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36063995
2.
Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compounds.
Bioorg Med Chem Lett
; 50: 128342, 2021 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34461178
3.
Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction.
Proc Natl Acad Sci U S A
; 112(4): 1196-201, 2015 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25583490
4.
Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.
Proc Natl Acad Sci U S A
; 112(45): 14078-83, 2015 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26508634
5.
Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus.
J Neurosci
; 35(19): 7600-15, 2015 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25972184
6.
VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy.
J Pharmacol Exp Ther
; 356(1): 123-36, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26503377
7.
M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's location.
J Neurosci
; 34(9): 3253-62, 2014 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24573284
8.
Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models.
J Neurosci
; 32(25): 8532-44, 2012 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22723693
9.
Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanism.
Drug Metab Dispos
; 41(9): 1703-14, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23821185
10.
Activation of Metabotropic Glutamate Receptor 3 Modulates Thalamo-accumbal Transmission and Rescues Schizophrenia-like Physiological and Behavioral Deficits.
Biol Psychiatry
; 2023 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38061467
11.
Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.
Mol Pharmacol
; 81(2): 120-33, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22021324
12.
Roles of the M1 muscarinic acetylcholine receptor subtype in the regulation of basal ganglia function and implications for the treatment of Parkinson's disease.
J Pharmacol Exp Ther
; 340(3): 595-603, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22135383
13.
Acute restraint stress redirects prefrontal cortex circuit function through mGlu5 receptor plasticity on somatostatin-expressing interneurons.
Neuron
; 110(6): 1068-1083.e5, 2022 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35045338
14.
Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071.
Bioorg Med Chem Lett
; 21(21): 6451-5, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21930376
15.
Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu2/mGlu4 receptor heterodimers.
Sci Signal
; 14(677)2021 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33824180
16.
Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus.
Biol Psychiatry
; 90(6): 385-398, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33965197
17.
A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning.
J Neurosci
; 29(45): 14271-86, 2009 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-19906975
18.
An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission.
Nat Chem Biol
; 4(1): 42-50, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18059262
19.
Ultrasound neuromodulation depends on pulse repetition frequency and can modulate inhibitory effects of TTX.
Sci Rep
; 10(1): 15347, 2020 09 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32948791
20.
Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.
J Neurosci
; 28(41): 10422-33, 2008 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-18842902