Incorporating medical code descriptions for diagnosis prediction in healthcare.

BACKGROUND: Diagnosis aims to predict the future health status of patients according to their historical electronic health records (EHR), which is an important yet challenging task in healthcare informatics. Existing diagnosis prediction approaches mainly employ recurrent neural networks (RNN) with attention mechanisms to make predictions. However, these approaches ignore the importance of code descriptions, i.e., the medical definitions of diagnosis codes. We believe that taking diagnosis code descriptions into account can help the state-of-the-art models not only to learn meaning code representations, but also to improve the predictive performance, especially when the EHR data are insufficient. METHODS: We propose a simple, but general diagnosis prediction framework, which includes two basic components: diagnosis code embedding and predictive model. To learn the interpretable code embeddings, we apply convolutional neural networks (CNN) to model medical descriptions of diagnosis codes extracted from online medical websites. The learned medical embedding matrix is used to embed the input visits into vector representations, which are fed into the predictive models. Any existing diagnosis prediction approach (referred to as the base model) can be cast into the proposed framework as the predictive model (called the enhanced model). RESULTS: We conduct experiments on two real medical datasets: the MIMIC-III dataset and the Heart Failure claim dataset. Experimental results show that the enhanced diagnosis prediction approaches significantly improve the prediction performance. Moreover, we validate the effectiveness of the proposed framework with insufficient EHR data. Finally, we visualize the learned medical code embeddings to show the interpretability of the proposed framework. CONCLUSIONS: Given the historical visit records of a patient, the proposed framework is able to predict the next visit information by incorporating medical code descriptions.

A two-step item bank calibration strategy based on 1-bit matrix completion for small-scale computerized adaptive testing.

Computerized adaptive testing (CAT) is a widely embraced approach for delivering personalized educational assessments, tailoring each test to the real-time performance of individual examinees. Despite its potential advantages, CAT�s application in small-scale assessments has been limited due to the complexities associated with calibrating the item bank using sparse response data and small sample sizes. This study addresses these challenges by developing a two-step item bank calibration strategy that leverages the 1-bit matrix completion method in conjunction with two distinct incomplete pretesting designs. We introduce two novel 1-bit matrix completion-based imputation methods specifically designed to tackle the issues associated with item calibration in the presence of sparse response data and limited sample sizes. To demonstrate the effectiveness of these approaches, we conduct a comparative assessment against several established item parameter estimation methods capable of handling missing data. This evaluation is carried out through two sets of simulation studies, each featuring different pretesting designs, item bank structures, and sample sizes. Furthermore, we illustrate the practical application of the methods investigated, using empirical data collected from small-scale assessments.