Jia-Wei-Si-Miao-Wan alleviates acute gouty arthritis by targeting NLRP3 inflammasome.

Gout is a common metabolic disease and acute gouty arthritis (AGA) is one of the important complications. Jia-Wei-Si-Miao-Wan is a newly developed drug for treating acute gouty arthritis, but the molecular mechanism has not been completely clarified. Thus, this study was aimed to explore the regulation of Jia-Wei-Si-Miao-Wan on NLRP3 inflammasome and TLR/NF-κB signaling, which are two important signaling pathways in inflammation. AGA rat model was established by injecting monosodium urate into the right knee. Colchicine and Jia-Wei-Si-Miao-Wan were administrated by gavage. The circumference of the knee was measured. IL-1ß and IL-18 level in the flushing fluid was detected by enzyme linked immunosorbent assay (ELISA). Western blot, immunohistochemistry and quantitative real-time RT-PCR were used to detect the protein and mRNA expression of TLR4, NLRP3, ASC, caspase-1, NF-κB and p-NF-κB. The results showed that IL-1ß and IL-18 level in the flushing fluid was increased and TLR4, NLRP3, ASC, caspase-1, NF-κB and p-NF-κB expressions were up-regulated after the establishment of AGA rat model. Colchicine and Jia-Wei-Si-Miao-Wan administration could alleviate the inflammation in the knee by inhibiting NLRP3 inflammasome and TLR/NF-κB signaling. In vivo data showed that the therapeutic effect of Jia-Wei-Si-Miao-Wan could be comparable with colchicine but had lower hepatic and renal toxicity. In conclusion, Targeting NLRP3 inflammasome and TLR/NF-κB signaling by Jia-Wei-Si-Miao-Wan could be effective in treating AGA.

Growth and laser properties of Nd3+-doped Bi4Ge3O12 single-crystal fiber.

The Nd3+-doped Bi4Ge3O12 (BGO) single-crystal fiber (SCF) was successfully grown by the micro-pulling-down method with the resistance heating system. The fluorescence spectrum and transmission spectrum of the Nd:BGO SCF were measured. Excited by a continuous-wave 808-nm laser diode, a fluorescence peak around 1064 nm was observed. At an absorbed pump power of 15.25 W, the Nd:BGO SCF laser delivered a power of 3.37 W with a slope efficiency of 31.2%.

[Correlation of baseline serum interleukin-6, 10 and its ratio with 7-year all-cause mortality in 11 communities of Beijing].

Objective: To evaluate whether baseline interleukin-6 (IL-6), interleukin-10 (IL-10) as well as their ratio was associated with overall mortality risk over 7 years of follow-up in 11 communities of Beijing. Methods: Data from a prospective cohort study conducted between 2005 and 2012 in 11 communities of Beijing was analyzed to examine the above associations. Serum IL-6 and IL-10 were analyzed using enzyme-linked immunosorbent assay (ELISA) kits. Follow-up surveys were conducted in 2007, 2010 and 2012 to collect data about participant's survival. Cox regression model was used to estimate the impact of IL-6, IL-10 and their ratio on overall mortality risk. Results: Among 1 539 eligible participants (10 263 total person-years), 77 deaths occurred in 7 years of follow-up. The rates of all-cause death were 4.86, 7.24, and 10.56 per 1 000 person-years (P=0.009) in the first, second, and third tertile of IL-6, respectively. The corresponding age-sex-adjusted hazard ratios (HR) were 1.00, 1.18 (95% CI: 0.64-2.19), and 1.80 (95% CI: 1.01-3.23) and full-adjusted HR were 1.00, 1.17 (95% CI: 0.63-2.19) and 1.87 (95% CI: 1.04-3.36). The corresponding rates of all-cause deaths were not significantly different among three tertiles of IL-10. The age-sex and full-adjusted HR were not significantly different in Cox model. The rates of all-cause death were 4.63, 8.99, and 8.93 per 1 000 person-years (P=0.043) in the first, second, and third tertile of IL-6/IL-10 ratio, respectively. The corresponding age-sex-adjusted HR were 1.00, 1.67 (95% CI: 0.91-3.06), and 1.98 (95% CI: 1.08-3.64) and full-adjusted HR were 1.00, 1.66 (95% CI: 0.90-3.06), and 2.09 (95% CI: 1.13-3.87). Conclusion: High IL-6 and IL-6/IL-10 ratio may be new risk factors to all-cause death. However, IL-10 is not significantly associated with death.

[Impact of the time from symptoms onset to thrombolysis on in-hospital major adverse cardiovascular event rate in patients with acute ST-segment elevation myocardial infarction].

OBJECTIVE: To explore the impact of thrombolytic therapy time delay on in-hospital major adverse cardiac event rate in patients with acute ST-segment elevation myocardial infarction (STEMI). METHODS: This survey was performed in 101 level 2 hospitals from 15 provinces or autonomous region in China. Patients admitted to these hospitals with acute STEMI during November 2011 to November 2014 and received thrombolytic therapy were eligible for this study. Multivariate logistic regression modeling was used to estimate the rate of in-hospital major adverse cardiac events (re-infarction, stroke and all-cause mortality) in patients with different thrombolytic time delay. RESULTS: A total of 3 719 STEMI patients received thrombolytic therapy, 88%(3 270 cases) of them were treated within 12 hours. After controlling for the impact of confounding factors, such as a variety of risk factors, past disease histories, the severity of STEMI, medication, interventions, etc, MACE rates significantly increased along with the thrombolysis time delay, no matter thrombolysis succeeded or not (trend test P<0.05). In group of successful thrombolysis, multivariate adjusted rate of MACE for 0-5.9 hours, 6.0-11.9 hours and ≥12.0 hours were 3.2%, 3.9% and 7.8%; in group of unsuccessful thrombolysis, it was 11.6%, 14.1% and 25.2% respectively (trend test P<0.05). The multivariate adjusted rates of re-infarction in group of successful thrombolysis as well as in group of unsuccessful thrombolysis significantly increased in proportion to thrombolysis time delay ≥ 12.0 h (trend test P<0.05). In group of successful thrombolysis, multivariate adjusted rate of re-infarction for 0-5.9 hours, 6.0-11.9 hours and ≥12.0 hours were 1.9%, 1.5% and 6.8%; in group of unsuccessful thrombolysis, it was 3.9%, 3.1% and 13.6%, respectively. Within the same time delay group, MACE and re-infarction rates were significantly lower in successful thrombolysis group than in unsuccessful thrombolysis group (all P<0.05). CONCLUSION: Thrombolytic therapy should be conducted within 6 hours after the attack. Both re-infarction or MACE rates are significantly increased in patients with more than 12 hours thrombolysis time delay.

Dual-wavelength synchronous operation of a mode-locked 2-µm Tm:CaYAlO4 laser.

We experimentally demonstrated dual-wavelength synchronous operation of a high-power passively mode-locked 2-µm Tm:CaYAlO4 (Tm:CYA) disordered crystal laser with semiconductor saturable absorber mirror (SESAM) as mode locker. The mode-locked laser emitted an average output power as high as 830 mW with pulse duration of 35.3 ps and repetition rate of 145.4 MHz. The mode-locking dual wavelengths were centered at 1958.9 nm and 1960.6 nm, respectively. Autocorrelation trace clearly shows beating pulses with pulse width of 3.5 ps and repetition rate of 0.13 THz.

Generation of 103 fs mode-locked pulses by a gain linewidth-variable Nd,Y:CaF2 disordered crystal.

We have demonstrated a diode-pumped passively mode-locked femtosecond Nd,Y:CaF2 disordered crystal laser for the first time to our knowledge. By choosing appropriate Y-doping concentration, a broad fluorescence linewidth of 31 nm has been obtained from the gain linewidth-variable Nd,Y:CaF2 crystal. With the Nd,Y:CaF2 disordered crystal as gain medium, the mode-locked laser generated pulses with pulse duration as short as 103 fs, average output power of 89 mW, and repetition rate of 100 MHz. To our best knowledge, this is the shortest pulse generated from Nd-doped crystal lasers so far. The research results show that the Nd,Y:CaF2 disordered crystal will be a potential alternative as gain medium of repetitive chirped pulse amplification for high-peak-power lasers.

Structural investigation and mechanical properties of a representative of a new class of materials: nanograined metallic glasses.

A new class of materials: Au-based nanograined metallic glasses (NGMGs) were synthesized using magnetron sputtering with powder targets. A detailed study by x-ray diffraction and high-resolution transmission electron microscopy (TEM) documents the unique nanoscale granular structure of the Au-based NGMG. This material inherited the good mechanical properties of metallic glasses, showing a high hardness of ∼5.3 GPa and a low elastic modulus of ∼79 GPa. In addition, in contrast to most MGs the nanoglassy particles can deform along the loading direction, exhibiting unique tensile elongation up to 100%. During thermal crystallization of NGMG material, even smaller sized Au solid solution nanocrystals are formed within the glassy nanograins, offering a new way for production of the nanocomposites with tailored structural length scales.

Diode-pumped mode-locked femtosecond Tm:CLNGG disordered crystal laser.

A diode-end-pumped passively mode-locked femtosecond Tm-doped calcium lithium niobium gallium garnet (Tm:CLNGG) disordered crystal laser was demonstrated for the first time to our knowledge. With a 790 nm laser diode pumping, stable CW mode-locking operation was obtained by using a semiconductor saturable absorber mirror. The disordered crystal laser generated mode-locked pulses as short as 479 fs, with an average output power of 288 mW, and repetition rate of 99 MHz in 2 µm spectral region.

Highly efficient 2 µm Tm:YAG ceramic laser.

We have experimentally demonstrated a highly efficient diode-pumped Tm:YAG ceramic laser operating at 2 µm wavelength. The maximum output power of 6.05 W was realized with a slope efficiency as high as 65%. As far as we know, it is the highest slope efficiency reported for Tm:YAG ceramic laser. The wavelength tuning experiment of Tm:YAG ceramic laser was carried out and the results suggest that Tm:YAG ceramic laser could operate simultaneously at multiple wavelengths in a wide range of 1884-2017 nm.

Graphene mode-locked femtosecond laser at 2 µm wavelength.

We experimentally demonstrated a passively mode-locked femtosecond laser by using a graphene-based saturable absorber mirror (graphene SAM) in the spectral region of 2 µm. The graphene SAM was fabricated by transferring chemical-vapor-deposited, high-quality, and large-area graphene on a highly reflective plane mirror. Stable mode-locked laser pulses as short as 729 fs were obtained with a repetition rate of 98.7 MHz and an average output power of 60.2 mW at 2018 nm.

Relationships between serum adiponectin, apelin, leptin, resistin, visfatin levels and bone mineral density, and bone biochemical markers in post-menopausal Chinese women.

BACKGROUND: Adiponectin, apelin, leptin, resistin, and visfatin, as the main circulating peptides secreted by adipose tissue, are potential contributors to bone metabolism. However, their association with bone mineral density (BMD) is unclear. AIM: The present study investigated whether these serum adipocytokines levels are associated with BMD and bone turnover markers. METHODS: Serum adiponectin, apelin, leptin, resistin, visfatin levels, bone turnover biochemical markers, and BMD were determined in 336 post-menopausal Chinese women (41-81 yr old). RESULTS: Adiponectin was negatively correlated with fat mass, while leptin had a positive correlation. In the multiple linear stepwise regression analysis, years since menopause, lean mass, estradiol, and adiponectin, but not fat mass, apelin, leptin, resistin, and visfatin, were independent predictors of BMD. The significant positive correlations between adiponectin and bone-specific alkaline phosphatase, bone crosslinked N-telopeptides of type I collagen were found. CONCLUSIONS: Adiponectin was an independent predictor of BMD in post-menopausal Chinese women, and positively correlated with bone turnover biochemical markers. It suggested that adiponectin may exert a negative effect on bone mass by promoting excessive bone resorption associated with bone loss in post-menopausal women.

Microwave radiation processing of metallic glassy powders.

In the present study we investigate the stability of Cu50Zr45Al5 and Ni59Ti16Zr20Sn5 glassy powders and the formation of the bulk metallic glassy samples by microwave heating in a single mode cavity (915 MHz) in the alternating magnetic field maximum. Metallic glasses exhibit low viscosity at temperatures close to the glass-transition which allows for the processing of glassy powders. Microwave heating being a volumetric heating has significant advantages over conventional heating in materials processing, such as substantial energy savings, high heating rates and process cleanness.

Efficient operation of a diode-pumped Yb:NaY(WO(4))(2) laser.

An efficient diode-pumped Yb:NaY(WO(4))(2) (Yb:NYW) disordered crystal laser has been experimentally demonstrated for the fist time. The Yb:NYW crystal has a peak absorption cross section of 1.09 x 10(-20) cm(2) at 972 nm and emission cross section of 1.24 x 10(-20) cm(2) at 1010 nm. Under an absorbed pump power of 11.7 W, the Yb:NYW laser generated an average output power as high as 4.1 W, with a slope efficiency of 45%. It was found that the laser always operated in a self-pulsing mode, and the laser spectrum showed random jumps with time. The mechanism of self-pulsing in the laser was also investigated.

Subpicosecond pulse generation from a Nd:CLNGG disordered crystal laser.

We report on a diode-pumped passively mode-locked subpicosecond Nd:CLNGG disordered crystal laser for the first time to our knowledge. Owing to the large inhomogeneous broadening and spectrum splitting of the disordered crystal, the Nd:CLNGG laser generated 900 fs mode-locked pulses with a repetition rate of approximately 88 MHz at 1061 nm wavelength. With a single-emitter laser diode pumping, a maximum average output power of 486 mW was achieved with a slope efficiency of 26%. Our experimental results show that the four-level Nd:CLNGG disordered crystal could be an excellent alternative for subpicosecond pulse generation.

Dual-wavelength synchronously mode-locked Nd:CNGG laser.

We have experimentally demonstrated a dual-wavelength synchronously mode-locked Nd:CNGG laser based on the semiconductor saturable absorber mirror technique. Mode locking was achieved simultaneously on two gain bands of the crystal that have a central wavelength separation of 2.4 nm. The fundamental mode-locked pulse train has a repetition rate of 88 MHz and pulse duration of 5 ps, with an average output power of approximately 90 mW. Autocorrelation measurements show that each of the synchronously mode-locked pulses consists of a train of quasi-periodic beat pulses with a 660 fs pulse width and a 0.63 THz repetition rate.

High-power self-mode-locked Yb:Y(2)O(3) ceramic laser.

We have experimentally demonstrated a high-power self-mode-locked Yb:Y(2)O(3) ceramic laser. Without any additional active or passive element in the cavity, self-started cw mode-locking was achieved. The maximum output power was as high as 2.7 W with a pulse duration of 1.1 ps. Numerical studies show that the diffraction loss induced by thermal lens aberration, in combination with the Kerr self-focusing effect in the gain medium, results in the mode locking of the laser. To our knowledge, this is the first self-mode-locked ceramic laser.