Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness.

Kaufmann, Kerstin B; Zeng, Andy G X; Coyaud, Etienne; Garcia-Prat, Laura; Papalexi, Efthymia; Murison, Alex; Laurent, Estelle M N; Chan-Seng-Yue, Michelle; Gan, Olga I; Pan, Kristele; McLeod, Jessica; Boutzen, Héléna; Zandi, Sasan; Takayanagi, Shin-Ichiro; Satija, Rahul; Raught, Brian; Xie, Stephanie Z; Dick, John E.

Nat Immunol ; 22(6): 723-734, 2021 06.

Artigo em Inglês | MEDLINE | ID: mdl-33958784

2.

A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latency.

Kaufmann, Kerstin B; Garcia-Prat, Laura; Liu, Qiang; Ng, Stanley W K; Takayanagi, Shin-Ichiro; Mitchell, Amanda; Wienholds, Erno; van Galen, Peter; Cumbaa, Christian A; Tsay, Mike J; Pastrello, Chiara; Wagenblast, Elvin; Krivdova, Gabriela; Minden, Mark D; Lechman, Eric R; Zandi, Sasan; Jurisica, Igor; Wang, Jean C Y; Xie, Stephanie Z; Dick, John E.

Blood ; 133(20): 2198-2211, 2019 05 16.

Artigo em Inglês | MEDLINE | ID: mdl-30796022

3.

Sphingolipids and HSC fitness: enigma no more.

Xie, Stephanie Z.

Blood ; 142(20): 1674-1676, 2023 11 16.

Artigo em Inglês | MEDLINE | ID: mdl-37971760

4.

Proton export takes charge of proliferation.

Xie, Stephanie Z.

Blood ; 139(4): 471-473, 2022 01 27.

Artigo em Inglês | MEDLINE | ID: mdl-35084476

5.

Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.

Foijer, Floris; Xie, Stephanie Z; Simon, Judith E; Bakker, Petra L; Conte, Nathalie; Davis, Stephanie H; Kregel, Eva; Jonkers, Jos; Bradley, Allan; Sorger, Peter K.

Proc Natl Acad Sci U S A ; 111(37): 13427-32, 2014 Sep 16.

Artigo em Inglês | MEDLINE | ID: mdl-25197064

6.

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

Gurumurthy, Sushma; Xie, Stephanie Z; Alagesan, Brinda; Kim, Judith; Yusuf, Rushdia Z; Saez, Borja; Tzatsos, Alexandros; Ozsolak, Fatih; Milos, Patrice; Ferrari, Francesco; Park, Peter J; Shirihai, Orian S; Scadden, David T; Bardeesy, Nabeel.

Nature ; 468(7324): 659-63, 2010 Dec 02.

Artigo em Inglês | MEDLINE | ID: mdl-21124451

7.

Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells.

Foijer, Floris; DiTommaso, Tia; Donati, Giacomo; Hautaviita, Katta; Xie, Stephanie Z; Heath, Emma; Smyth, Ian; Watt, Fiona M; Sorger, Peter K; Bradley, Allan.

Proc Natl Acad Sci U S A ; 110(8): 2928-33, 2013 Feb 19.

Artigo em Inglês | MEDLINE | ID: mdl-23382243

8.

Mps1 at kinetochores is essential for female mouse meiosis I.

Hached, Khaled; Xie, Stephanie Z; Buffin, Eulalie; Cladière, Damien; Rachez, Christophe; Sacras, Marina; Sorger, Peter K; Wassmann, Katja.

Development ; 138(11): 2261-71, 2011 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-21558374

9.

Metformin reduces the clonal fitness of Dnmt3a^R878H hematopoietic stem and progenitor cells by reversing their aberrant metabolic and epigenetic state.

Hosseini, Mohsen; Voisin, Veronique; Chegini, Ali; Varesi, Angelica; Cathelin, Severine; Ayyathan, Dhanoop Manikoth; Liu, Alex C H; Yang, Yitong; Wang, Vivian; Maher, Abdula; Grignano, Eric; Reisz, Julie A; D'Alessandro, Angelo; Young, Kira; Wu, Yiyan; Fiumara, Martina; Ferrari, Samuele; Naldini, Luigi; Gaiti, Federico; Pai, Shraddha; Schimmer, Aaron D; Bader, Gary D; Dick, John E; Xie, Stephanie Z; Trowbridge, Jennifer J; Chan, Steven M.

Res Sq ; 2024 Feb 06.

Artigo em Inglês | MEDLINE | ID: mdl-38405837

10.

Transcriptional Activation of Regenerative Hematopoiesis via Vascular Niche Sensing.

Itkin, Tomer; Houghton, Sean; Schreiner, Ryan; Lin, Yang; Badwe, Chaitanya R; Voisin, Veronique; Murison, Alex; Seyedhassantehrani, Negar; Kaufmann, Kerstin B; Garcia-Prat, Laura; Booth, Gregory T; Geng, Fuqiang; Liu, Ying; Gomez-Salinero, Jesus M; Shieh, Jae-Hung; Redmond, David; Xiang, Jenny Z; Josefowicz, Steven Z; Trapnell, Cole; Spencer, Joel A; Zangi, Lior; Hadland, Brandon; Dick, John E; Xie, Stephanie Z; Rafii, Shahin.

bioRxiv ; 2023 Mar 29.

Artigo em Inglês | MEDLINE | ID: mdl-37034724

11.

Lipids and the cancer stemness regulatory system in acute myeloid leukemia.

Lim, Isabel N X; Nagree, Murtaza S; Xie, Stephanie Z.

Essays Biochem ; 66(4): 333-344, 2022 09 16.

Artigo em Inglês | MEDLINE | ID: mdl-35996953

12.

Multiomic Profiling of Central Nervous System Leukemia Identifies mRNA Translation as a Therapeutic Target.

Vanner, Robert J; Dobson, Stephanie M; Gan, Olga I; McLeod, Jessica; Schoof, Erwin M; Grandal, Ildiko; Wintersinger, Jeff A; Garcia-Prat, Laura; Hosseini, Mohsen; Xie, Stephanie Z; Jin, Liqing; Mbong, Nathan; Voisin, Veronique; Chan-Seng-Yue, Michelle; Kennedy, James A; Waanders, Esmé; Morris, Quaid; Porse, Bo; Chan, Steven M; Guidos, Cynthia J; Danska, Jayne S; Minden, Mark D; Mullighan, Charles G; Dick, John E.

Blood Cancer Discov ; 3(1): 16-31, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-35019858

13.

SUMO wrestling cancer stem cells.

Liu, Qiang; Wang, Jean C Y; Xie, Stephanie Z.

Cell Chem Biol ; 28(10): 1390-1392, 2021 10 21.

Artigo em Inglês | MEDLINE | ID: mdl-34678166

14.

TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate.

García-Prat, Laura; Kaufmann, Kerstin B; Schneiter, Florin; Voisin, Veronique; Murison, Alex; Chen, Jocelyn; Chan-Seng-Yue, Michelle; Gan, Olga I; McLeod, Jessica L; Smith, Sabrina A; Shoong, Michelle C; Parris, Darrien; Pan, Kristele; Zeng, Andy G X; Krivdova, Gabriela; Gupta, Kinam; Takayanagi, Shin-Ichiro; Wagenblast, Elvin; Wang, Weijia; Lupien, Mathieu; Schroeder, Timm; Xie, Stephanie Z; Dick, John E.

Cell Stem Cell ; 28(10): 1838-1850.e10, 2021 10 07.

Artigo em Inglês | MEDLINE | ID: mdl-34343492

15.

The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization.

Takayama, Naoya; Murison, Alex; Takayanagi, Shin-Ichiro; Arlidge, Christopher; Zhou, Stanley; Garcia-Prat, Laura; Chan-Seng-Yue, Michelle; Zandi, Sasan; Gan, Olga I; Boutzen, Héléna; Kaufmann, Kerstin B; Trotman-Grant, Aaron; Schoof, Erwin; Kron, Ken; Díaz, Noelia; Lee, John J Y; Medina, Tiago; De Carvalho, Daniel D; Taylor, Michael D; Vaquerizas, Juan M; Xie, Stephanie Z; Dick, John E; Lupien, Mathieu.

Cell Stem Cell ; 28(3): 488-501.e10, 2021 03 04.

Artigo em Inglês | MEDLINE | ID: mdl-33242413

16.

Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation.

Xie, Stephanie Z; Kaufmann, Kerstin B; Wang, Weijia; Chan-Seng-Yue, Michelle; Gan, Olga I; Laurenti, Elisa; Garcia-Prat, Laura; Takayanagi, Shin-Ichiro; Ng, Stanley W K; Xu, ChangJiang; Zeng, Andy G X; Jin, Liqing; McLeod, Jessica; Wagenblast, Elvin; Mitchell, Amanda; Kennedy, James A; Liu, Qiang; Boutzen, Héléna; Kleinau, Melissa; Jargstorf, Joseph; Holmes, Gareth; Zhang, Yang; Voisin, Veronique; Bader, Gary D; Wang, Jean C Y; Hannun, Yusuf A; Luberto, Chiara; Schroeder, Timm; Minden, Mark D; Dick, John E.

Blood Cancer Discov ; 2(1): 32-53, 2021 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-33458693

17.

Human Aging Alters the Spatial Organization between CD34+ Hematopoietic Cells and Adipocytes in Bone Marrow.

Aguilar-Navarro, Alicia G; Meza-León, Berenice; Gratzinger, Dita; Juárez-Aguilar, Fany G; Chang, Qing; Ornatsky, Olga; Tsui, Hubert; Esquivel-Gómez, Ricardo; Hernández-Ramírez, Antonio; Xie, Stephanie Z; Dick, John E; Flores-Figueroa, Eugenia.

Stem Cell Reports ; 15(2): 317-325, 2020 08 11.

Artigo em Inglês | MEDLINE | ID: mdl-32649902

18.

Relapse-Fated Latent Diagnosis Subclones in Acute B Lineage Leukemia Are Drug Tolerant and Possess Distinct Metabolic Programs.

Dobson, Stephanie M; García-Prat, Laura; Vanner, Robert J; Wintersinger, Jeffrey; Waanders, Esmé; Gu, Zhaohui; McLeod, Jessica; Gan, Olga I; Grandal, Ildiko; Payne-Turner, Debbie; Edmonson, Michael N; Ma, Xiaotu; Fan, Yiping; Voisin, Veronique; Chan-Seng-Yue, Michelle; Xie, Stephanie Z; Hosseini, Mohsen; Abelson, Sagi; Gupta, Pankaj; Rusch, Michael; Shao, Ying; Olsen, Scott R; Neale, Geoffrey; Chan, Steven M; Bader, Gary; Easton, John; Guidos, Cynthia J; Danska, Jayne S; Zhang, Jinghui; Minden, Mark D; Morris, Quaid; Mullighan, Charles G; Dick, John E.

Cancer Discov ; 10(4): 568-587, 2020 04.

Artigo em Inglês | MEDLINE | ID: mdl-32086311

19.

Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal.

Xie, Stephanie Z; Garcia-Prat, Laura; Voisin, Veronique; Ferrari, Robin; Gan, Olga I; Wagenblast, Elvin; Kaufmann, Kerstin B; Zeng, Andy G X; Takayanagi, Shin-Ichiro; Patel, Ishita; Lee, Esther K; Jargstorf, Joseph; Holmes, Gareth; Romm, Guy; Pan, Kristele; Shoong, Michelle; Vedi, Aditi; Luberto, Chiara; Minden, Mark D; Bader, Gary D; Laurenti, Elisa; Dick, John E.

Cell Stem Cell ; 25(5): 639-653.e7, 2019 11 07.

Artigo em Inglês | MEDLINE | ID: mdl-31631013

20.

Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.

Foijer, Floris; Albacker, Lee A; Bakker, Bjorn; Spierings, Diana C; Yue, Ying; Xie, Stephanie Z; Davis, Stephanie; Lutum-Jehle, Annegret; Takemoto, Darin; Hare, Brian; Furey, Brinley; Bronson, Roderick T; Lansdorp, Peter M; Bradley, Allan; Sorger, Peter K.

Elife ; 62017 03 20.

Artigo em Inglês | MEDLINE | ID: mdl-28318489

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