RESUMO
BACKGROUND: Magnetic therapy may have some potential in treating osteoporosis, and this meta-analysis aims to study the efficacy of magnetic therapy for osteoporotic patients. METHODS: We have searched several databases including PubMed, EMbase, Web of Science, EBSCO and Cochrane library databases, and selected the randomized controlled trials comparing the efficacy of magnetic therapy for osteoporotic patients. This meta-analysis was conducted using the random-effect or fixed-effect model based on the heterogeneity. RESULTS: Five randomized controlled trials were included in this meta-analysis. Compared with sham procedure in osteoporotic patients, magnetic therapy was associated with significantly increased bone mineral density (standard mean difference [SMD]â =â 2.39; 95% confidence interval [CI]â =â 0.27-4.51; Pâ =â .03), decreased pain scores (mean difference [MD]â =â -0.86; 95% CIâ =â -1.04 to -0.67; Pâ <â .00001), and calcium (MDâ =â -0.61; 95% CIâ =â -0.92 to -0.29; Pâ =â .0002), but revealed no influence on phosphate (MDâ =â 0.07; 95% CIâ =â -0.30 to 0.44; Pâ =â .71), osteocalcin (SMDâ =â 0.65; 95% CIâ =â -2.87 to 4.17; Pâ =â .72), or ALP (SMDâ =â -0.43; 95% CIâ =â -0.92 to 0.07; Pâ =â .09). CONCLUSIONS: Magnetic therapy may be effective for the treatment of osteoporotic patients.
Assuntos
Osteoporose , Humanos , Osteoporose/terapia , Fenômenos MagnéticosRESUMO
Radiation therapy, one of the major treatment options for cancer, can cause delayed heart damage. The circular RNA (circRNA) circFOXO3 (hsa_circ_0006404) is associated with cancer progression. However, the functions of circFOXO3 in radiationinduced cardiotoxicity remains unknown. The present study aimed to identify the functions of cirFOXO3 in radiationinduced cardiotoxicity. The present study established circFOXO3knockdown (KD) or overexpressing (OE) cardiomyocytes. Functional assay results showed that KD of circFOXO3 in cardiomyocytes significantly increased DNA damage and apoptosis after radiation. By contrast, OE of circFOXO3 reduced DNA damage and apoptosis rates in response to radiation. Mechanistically, KD of circFOXO3 elevated the levels of Bax, caspase 3 and caspase 7, and decreased Bcl2 expression, whereas OE of circFOXO3 decreased Bax, caspase 3 and caspase 7 expression, and increased Bcl2 expression. Thus, the present study indicated that circFOXO3 protected cardiomyocytes from radiationinduced cardiotoxicity by reducing DNA damage and apoptosis. circFOXO3 may be a potential therapeutic target against radiationinduced cardiotoxicity.