Detalhe da pesquisa
1.
Selection of an Optimal In Vitro Model to Assess P-gp Inhibition: Comparison of Vesicular and Bidirectional Transcellular Transport Inhibition Assays.
Drug Metab Dispos
; 50(7): 909-922, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35489778
2.
Role of transporters in the disposition of a novel ß-lactamase inhibitor: relebactam (MK-7655).
J Antimicrob Chemother
; 74(7): 1894-1903, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30891606
3.
Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model.
Mol Pharmacol
; 89(5): 492-504, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26893303
4.
Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins.
Drug Metab Dispos
; 42(8): 1301-13, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24855184
5.
Variability in P-glycoprotein inhibitory potency (IC50) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment decision criteria.
Drug Metab Dispos
; 41(7): 1347-66, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23620485
6.
Characterization of multidrug resistance 1a/P-glycoprotein knockout rats generated by zinc finger nucleases.
Mol Pharmacol
; 81(2): 220-7, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22049154
7.
Metabolic activation and major protein target of a 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonist.
Chem Res Toxicol
; 25(7): 1412-22, 2012 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22765480
8.
In Vitro Assessment of Transporter Mediated Perpetrator DDIs for Several Hepatitis C Virus Direct-Acting Antiviral Drugs and Prediction of DDIs with Statins Using Static Models.
AAPS J
; 24(3): 45, 2022 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35314909
9.
Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes.
Nucleic Acids Res
; 37(4): 1160-73, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19129222
10.
Glutathione depletion and oxidative stress.
Parkinsonism Relat Disord
; 8(6): 385-7, 2002 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-12217624
11.
Determining P-glycoprotein-drug interactions: evaluation of reconstituted P-glycoprotein in a liposomal system and LLC-MDR1 polarized cell monolayers.
J Pharmacol Toxicol Methods
; 65(2): 64-74, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22394995
12.
Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein.
J Pharmacol Exp Ther
; 321(2): 673-83, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17314201
13.
Identification of potential pharmacological and toxicological targets differentiating structural analogs by a combination of transcriptional profiling and promoter analysis in LS-180 and Caco-2 adenocarcinoma cell lines.
Pharmacogenet Genomics
; 16(8): 579-99, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16847427
14.
Characterization of mice lacking the multidrug resistance protein MRP2 (ABCC2).
J Pharmacol Exp Ther
; 317(2): 579-89, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16421286
15.
Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures.
J Neurochem
; 81(2): 301-6, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-12064477
16.
Toxicity of glutathione depletion in mesencephalic cultures: a role for arachidonic acid and its lipoxygenase metabolites.
Eur J Neurosci
; 19(2): 280-6, 2004 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-14725622