Biochar-Assisted Catalytic Pyrolysis of Oily Sludge to Attain Harmless Disposal and Residue Utilization for Soil Reclamation.

Pyrolysis of oily sludge (OS) is a feasible technology to match the principle of reduction and recycling; however, it is difficult to confirm the feasible environmental destination and meet the corresponding requirements. Therefore, an integrated strategy of biochar-assisted catalytic pyrolysis (BCP) of OS and residue utilization for soil reclamation is investigated in this study. During the catalytic pyrolysis process, biochar as a catalyst intensifies the removal of recalcitrant petroleum hydrocarbons at the expense of liquid product yield. Concurrently, biochar as an adsorbent can inhibit the release of micromolecular gaseous pollutants (e.g. HCN, H2S, and HCl) and stabilize heavy metals. Due to the assistance of biochar, pyrolysis reactions of OS are more likely to occur and require a lower temperature to achieve the same situation. During the soil reclamation process, the obtained residue as a soil amendment can not only provide a carbon source and mineral nutrients but can also improve the abundance and diversity of microbial communities. Thus, it facilitates the plant germination and the secondary removal of petroleum hydrocarbons. The integrated strategy of BCP of OS and residue utilization for soil reclamation is a promising management strategy, which is expected to realize the coordinated and benign disposal of more than one waste.

Engineering Multishelled Nanostructures Enables Stepwise Self-Degradability for Drug-Release Optimization.

The balance between degradability and drug release kinetics is a major challenge for the development of drug delivery systems. Here we develop hierarchically structured nanoparticles comprising multiple noncontact silica shells using an amorphous calcium carbonate template. The system could be degraded in a sequential fashion on account of the molecularly engineered multishelled structures. The hydrolysis rate of drug-containing cores is inversely correlated with the nanoparticle concentration due to the shielding effect of the hierarchical nanostructure and could be exploited to regulate the release kinetics. Specifically, multishelled nanospheres show a low drug release rate with high doses that increases steadily as the concentration decreases due to continuous degradation, thus stabilizing the local drug concentration for effective tumor therapy. Moreover, the nanoparticles could be eventually degraded completely, which may reduce their health risks. This kind of hierarchically structured silica-based nanoparticle could serve as a sustainable drug depot and provides a new avenue for tumor treatment.

Evaluation of the Flexibility for Catalytic Ozonation of Dichloromethane over Urchin-Like CuMnOx in Flue Gas with Complicated Components.

The evaluation of the poisoning effect of complex components in practical gas on DCM (dichloromethane) catalytic ozonation is of great significance for enhancing the technique's environmental flexibility. Herein, Ca, Pb, As, and NO/SO2 were selected as a typical alkaline-earth metal, heavy metal, metalloid, and acid gas, respectively, to evaluate their interferences on catalytic behaviors and surface properties of an optimized urchin-like CuMn catalyst. Ca/Pb loading weakens the formation of oxygen vacancies, oxygen mobility, and acidity due to the fusion of Mn-Ca/Pb-O, leading to their inferior catalytic performance with poor CO2 selectivity and mineralization rate. Noticeably, the presence of As induces excessively strong acidity, facilitating the inevitable formation of byproducts. Catalytic co-ozonation of NO/DCM is achieved with stoichiometric ozone addition. Unfortunately, SO2 introduction brings irreversible deactivation due to strong competition adsorption and the loss of active sites. Unexpectedly, Ca loading protects active sites from an attack by SO2. The formation of unstable sulfites and the released Mn-O structure offset the negative effect from SO2. Overall, the catalytic ozonation of DCM exhibits a distinctive priority in the antipoisoning of metals with the maintenance of DCM conversion. The construction of more stable acid sites should be the future direction of catalyst design; otherwise, catalytic ozonation should be arranged together with post heavy metal capture and a deacidification system.

Bio-Inspired Lotus-Fiber-like Spiral Hydrogel Bacterial Cellulose Fibers.

Hydrogel materials with high water content and good biocompatibility are drawing more and more attention now, especially for biomedical use. However, it still remains a challenge to construct hydrogel fibers with enough strength and toughness for practical applications. Herein, we report a bio-inspired lotus-fiber-mimetic spiral structure hydrogel bacterial cellulose fiber with high strength, high toughness, high stretchability, and energy dissipation, named biomimetic hydrogel fiber (BHF). The spiral-like structure endows BHF with excellent stretchability through plastic deformation and local failure, assisted by the breaking-reforming nature of the hydrogen bonding network among cellulose nanofibers. With the high strength, high stretchability, high energy dissipation, high hydrophilicity, porous structure, and excellent biocompatibility, BHF is a promising hydrogel fiber for biomedicine. The outstanding stretchability and energy dissipation of BHF allow it to absorb energy from the tissue deformation around a wound and effectively protect the wound from rupture, which makes BHF an ideal surgical suture.

Hydrothermal oxygen uncoupling of high-concentration biogas slurry over Cu-α-Fe2O3·α-MoO3 catalyst.

A hydrothermal oxygen uncoupling (HTOU) method which combines aqueous phase reforming (APR) and oxygen uncoupling was proposed to treat biogas slurry (BS). Based on Le Chatelier's principle, this novel approach was constructed and realized by Cu-α-Fe2O3·α-MoO3 catalyst with van der Waals heterojunction-redox property. Additionally, the catalyst was synthesized by integrating a simple one-pot sol-gel method and thermal hydrogenating. Results indicated that the optimal removal efficiencies of non-purgeable organic carbon (NPOC) (76.29%), total nitrogen (TN) (45.56%), and ammonia nitrogen (AN) (29.03%) were achieved on the Cu-α-Fe2O3·α-MoO3 catalyst at 225.00 °C for 30.00 min, respectively. The significant performance of Cu-α-Fe2O3·α-MoO3 could be attributed to three aspects. (1) The α-MoO3 nanosheets with van der Waals heterostructures obtained at the calcination temperature of 600.00 °C, which can provide the superior performance of APR for hydrogen generation. (2) The adsorbed oxygen species were eliminated by thermal hydrogenating which had a surface passivation effect. (3) The effect of oxygen uncoupling in the lattice oxygen and gaseous oxygen release reaction was beneficial to the degradation of organic matter. Moreover, the reuse of catalysts studies further revealed that the deactivation of catalysts originated from carbon deposition of aromatic polymers and heavy metals oxides pollution. Overall, these findings disclosed that the HTOU could be a promising alternative to the treatment of high-concentration organic wastewater.

Amorphous Calcium Carbonate Cluster Nanospheres in Water-Deficient Organic Solvents.

As the key intermediate phase of crystalline calcium carbonate biominerals, amorphous calcium carbonate (ACC) remains mysterious in its structures because of its long-range disorder and instability. We herein report the synthesis of ACC nanospheres in a water-deficient organic solvent system. The obtained ACC nanospheres are very stable under dry conditions. Cryo-TEM reveals that each nanospheres consists of smaller nanosized clusters. We further demonstrate that these clusters can precipitate on other substrates to form an ultrathin ACC coating, which should be an ACC cluster monolayer. The results demonstrate that the presence of small ACC clusters as the subunits of larger aggregates is inherent to ACC synthesized in water-alcohol system but not induced by polymer additives.

Comparative Investigation on Chlorobenzene Oxidation by Oxygen and Ozone over a MnOx/Al2O3 Catalyst in the Presence of SO2.

Catalytic oxidation of volatile organic compounds (VOCs) usually encounters complicated components in flue gas causing severe deactivation that restrict its application in specific conditions. The Cl substitution in chlorobenzene further increases poisoning risks. Ozone assistance has unique superiority that can overcome these bottleneck problems. Herein, this study performs a comparative investigation of CB oxidation by oxygen and ozone over a simple Mn/Al2O3 catalyst. CB conversion suffered from slight deactivation in oxygen atmosphere (from 90 to 70%) and more severe deactivation in the presence of SO2 (from 90 to 45%) at 480 °C. Introduction of ozone successfully attained high CB conversion at low temperature (120 °C) with excellent stability and less byproducts. Especially, CB oxidation by ozone maintained its original conversion in the presence of SO2. The deactivation process was simulated by synthesizing several sulfated catalysts. Direct sulfation on Mn/Al2O3 attained more severe deactivation in CB conversion and CO2 formation than sulfation on the Al2O3 support. Ozone with a strong oxidation property promoted the CB oxidation cycle, facilitated desorption of carbonaceous intermediates, and protected MnOx species from severe erosion, thus exhibiting high and stable performance in CB oxidation.

Correlation of Active Sites to Generated Reactive Species and Degradation Routes of Organics in Peroxymonosulfate Activation by Co-Loaded Carbon.

Peroxymonosulfate (PMS)-based advanced oxidation processes (PMS-AOPs) as an efficient strategy for organic degradation are highly dependent on catalyst design and structured active sites. However, the identification of the active sites and their relationship with reaction mechanisms for organic degradation are not fully understood for a composite catalyst due to the complex structure. Herein, we developed a family of Co encapsulated in N-doped carbons (Co-PCN) with tailored types and contents of active sites via manipulated pyrolysis for PMS activation and ciprofloxacin (CIP) degradation, focusing on the correlation of active sites to generated reactive species and degradation routes of organics. The structure-function relationships between the different active sites in Co-PCN catalysts and reactive oxygen species (ROS), as well as bond breaking position of CIP, were revealed through regression analysis and density functional theory calculation. Co-Nx, O-C═O, C═O, graphitic N, and defects in Co-PCN stimulate the generation of 1O2 for oxidizing the C-C bond in the piperazine ring of CIP into C═O. The substitution of F by OH and hydroxylation of the piperazine ring might be induced by SO4•- and •OH, whose formation was affected by C-O, Co(0), Co-Nx, graphitic N, and defects. The findings provided new insights into reaction mechanisms in PMS-AOP systems and rational design of catalysts for ROS-oriented degradation of pollutants.

Triple combination of natural microbial action, etching, and gas foaming to synthesize hierarchical porous carbon for efficient adsorption of VOCs.

Fungi residue, vinasse, and biogas residue differ from general biomass waste due to natural microbial action. Microbial fermentation helps create natural channels for the permeation of activators and produces proteins for natural nitrogen doping. Inspired by these advantages on porous carbon synthesis, this study adopted dual activators of KOH and KHCO3 to synthesize porous carbon with different pore ratios for efficient adsorption of volatile organic compounds (VOCs). The fungi residue possessed the least lignin due to the most severe microbial action, contributing to the best pore structures after activation. The etching effect from potassium compounds and gas foaming from the carbonate decomposition contributed to creating hierarchical porous carbon with ultra-high surface area, ca. 1536.8-2326.5 m2/g. However, KHCO3 addition also caused nitrogen erosion, such that lower adsorption capacity was attained even with a higher surface area when the mass ratio of KOH/KHCO3 decreased from 2.5:0.5 to 2:1. The maximum adsorption capacities of chlorobenzene (CB) and benzene (PhH) reached 594.0 and 394.3 mg/g, respectively. Pore structure variations after adsorption were evaluated by freeze treatment to discover the adsorption mechanism. The surface area after CB and PhH adsorption decreased 40.3% and 34.5%, respectively. Most of the mesopores might transform into micropores due to the mono/multilayer stacking of adsorbates. The VOC adsorption kinetics were simulated by the Pseudo-first- and -second-order models and Y-N model. This paper provides a new approach for high-value biomass waste utilization after microbial action to synthesize efficient adsorbents for VOCs.

Catalytic Reforming: A Potentially Promising Method for Treating and Utilizing Wastewater from Biogas Plants.

This study investigated catalytic reforming, which is a thermochemical process, as a pioneering method to treat biogas slurry (wastewater from biogas plants) and generate hydrogen. Experimental validation for treating biogas slurries from digested cattle manure, fish intestine, and wheat straw was performed on Ni/α-Al2O3 catalyst. The results showed that the total organic carbon, total nitrogen, and PO43- ion contents in biogas slurry could be reduced by 98.69, 98.01, and 99.32%, respectively. The highest hydrogen yield was obtained in the treatment of biogas slurry from digested cattle manure at 750 °C, in which the hydrogen yield and hydrogen concentration were 13.85 Lhydrogen/LBS and 79.77 vol %, respectively. Changes in the crystalline phase and structure of the catalyst were observed during catalytic reforming of biogas slurry. Active metal oxidization and carbon deposition were likely to be important factors affecting catalytic stability. The mass flow evaluation verified the hydrogen generation potential by the catalytic reforming of biogas slurry, which was close to the methane generation capability of the upstream biogas plant. However, additional effort is required to address the high energy consumption of this method. These findings provide fundamental knowledge about the potential of applying thermochemical techniques to treat and utilize high total organic carbon-containing wastewaters.

The role of seashell wastes in TiO2/Seashell composites: Photocatalytic degradation of methylene blue dye under sunlight.

This paper proposes a sustainable and facile approach for the synthesis of photocatalysts in which shell waste is used as support material. The synthesized photocatalysts exhibited a significant performance in the mineralization of organic substances under solar irradiation or artificial lighting. Calcined abalone shell with a TiO2 loading of 23.4% led to a significant improvement in optical absorption: the degradation efficiencies of methylene blue (MB) after 140 min under UV light, vis light, UV-vis light, and natural sunlight were 93%, 96%, 100%, and 100%, respectively. Notably, the byproducts obtained after the degradation by commercial P25 TiO2 disappeared with the utilization of shell waste as support material. The Na, Sr, S present in the calcined abalone shell were doped into the substitutional sites of TiO2 and were indispensable to achieve the desired band-gap narrowing and photocatalytic performance; moreover, the Ti and Zn oxides in the calcined abalone shell acted as semiconductors and improved the charge separation efficiency of TiO2. Above all, this paper describes a green synthesis based on the use of waste seashell. This material acts as an excellent photocatalyst support for environmental pollution treatments, leading to the 'control of waste by waste' and opening up new possibilities for shell waste reutilization and sustainable chemistry.

Performance of chemical chelating agent stabilization and cement solidification on heavy metals in MSWI fly ash: A comparative study.

Heavy metal stabilization by chemical chelating agent and solidification by cement are technologies currently used to reduce the leaching of heavy metals in municipal solid waste incineration (MSWI) fly ash. This paper studied the physico-chemical properties of the fly ash, heavy metals content in the fly ash, and the leaching concentration of the heavy metals from fly ash. The effect of four chelating agents namely dithiocarbamate (1#), dithiocarbamic acid dipotassium salt (2#), amino dithiocarbamate chelating resin (3#) and thiourea (4#) on the stabilization and leaching of heavy metals were investigated. Different addition ratios (1%, 2% and 3% w/w) of the chelating agents, various curing time (7, 14, 28 days), and different amounts of the cement (10%, 15% and 20% w/w) were used in order to find the agent with the optimum stabilization and leaching of heavy metals as well as find the effect of combining the agent and cement. The results showed that the dithiocarbamate (1#) chelating agent had the best stabilizing performance due to the three-dimensional structure after their reaction. The addition of cement to the fly ash led to the immobilization of heavy metals due to the C-S-H gel formation. The technology of cement solidification and chelating agent stabilization was optimal from the point of economic cost and the complexity aspect.

Cryoprotectant choice and analyses of freeze-drying drug suspension of nanoparticles with functional stabilisers.

Freeze-drying is an effective way to improve long-term physical stability of nanosuspension in drug delivery applications. Nanosuspension also known as suspension of nanoparticles. In this study, the effect of freeze-drying with different cryoprotectants on the physicochemical characteristics of resveratrol (RSV) nanosuspension and quercetin (QUE) nanosuspension was evaluated. D-α-tocopheryl polyethylene glycol succinate (TPGS) and folate-modified distearoylphosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG-FA) were selected as functional stabilisers formulated nanosuspension which were prepared by anti-solvent precipitation method. RSV nanoparticle size and QUE nanoparticle size were about 210 and 110 nm, respectively. The AFM and TEM results of nanosuspension showed uniform and irregular shape particles. After freeze-drying, the optimal concentration of four cryoprotectants was determined by the particle size of re-dispersed nanoparticles. The dissolution profile of drug nanoparticle significantly showed approximately at a 6-8-fold increase dissolution rate. Moreover, TPGS and DSPE-PEG-FA stabilised RSV nanosuspension and QUE nanosuspension samples showed better effect on long-term physical stability.

Two-step biocatalytic process using lipase and whole cell catalysts for biodiesel production from unrefined jatropha oil.

OBJECTIVE: To avoid lipase deactivation by methanol in the enzymatic transesterification process, a two-step biocatalytic process for biodiesel production from unrefined jatropha oil was developed. RESULTS: Unrefined jatropha oil was first hydrolyzed to free fatty acids (FFAs) by the commercial enzyme Candida rugosa lipase. The maximum yield achieved of FFAs 90.3% at 40 °C, water/oil ratio 0.75:1 (v/v), lipase content 2% (w/w) after 8 h reaction. After hydrolysis, the FFAs were separated and converted to biodiesel by using Rhizopus oryzae IFO4697 cells immobilized within biomass support particles as a whole-cell biocatalyst. Molecular sieves (3 Å) were added to the esterification reaction mixture to remove the byproduct water. The maximum fatty acid methyl ester yield reached 88.6% at 35 °C, molar ratio of methanol to FFAs 1.2:1, molecular sieves (3 Å) content 60% (w/w) after 42 h. In addition, both C. rugosa lipase and R. oryzae whole cell catalyst in the process showed excellent reusability, retaining 89 and 79% yields, respectively, even after six batches of reactions. CONCLUSION: This novel process, combining the advantages of enzyme and whole cell catalysts, saved the consumption of commercial enzyme and avoid enzyme deactivation by methanol.

[Quantitative Measurement of Equivalence Ratios of Methane/Air Mixture by Laser-Induced Breakdown Spectroscopy: the Effects of Detector Gated Mode and Laser Wavelength].

Laser-induced breakdown spectroscopy (LIBS) has been increasingly used in combustion diagnostics as a novel spectral analysis method in recent years. The quantitative local equivalence ratio of methane/air mixture is determined by LIBS using different emission intensity ratios of H/O and H/N. The comparison between calibration curves of H656/O777 and H656/N746 is performed in gated mode, which shows that H656/O777 can achieve better prediction accuracy and higher sensitivity. More spectral intensity ratios (H656/O777, H656/N500⁺, H656/N567 and H656/N746) can be used to make calibration measurements in ungated mode and H656/O777 is also tested best among them. The comparison between gated and ungated detection modes shows that gated mode offers better accuracy and precision. In addition, the effects of different laser wavelengths (1064, 532 and 355 nm) on LIBS spectra and calibration curves are investigated with laser focal point size and laser fluence kept constant. The results show that with longer laser wavelength, the peak intensity and SNR of H, O and N lines increase, as well as the slope of calibration curve of H656/O777. Among these three wavelengths, 1064 nm laser is best suited to measure the equivalence ratio of CH4/air mixture by LIBS. The experimental results are explained in terms of plasma electron density and temperature, which have a significant impact on the emission intensity and the partition function of hydrogen and oxygen, respectively.

Biodiesel production in a magnetically-stabilized, fluidized bed reactor with an immobilized lipase in magnetic chitosan microspheres.

Biodiesel production by immobilized Rhizopus oryzae lipase in magnetic chitosan microspheres (MCMs) was carried out using soybean oil and methanol in a magnetically-stabilized, fluidized bed reactor (MSFBR). The maximum content of methyl ester in the reaction mixture reached 91.3 (w/v) at a fluid flow rate of 25 ml/min and a magnetic field intensity of 150 Oe. In addition, the MCMs-immobilized lipase in the reactor showed excellent reusability, retaining 82 % productivity even after six batches, which was much better than that in a conventional fluidized bed reactor. These results suggested that a MSFRB using MCMs-immobilized lipase is a promising method for biodiesel production.

Effect of heterogeneous fenton-like pretreatment on semi-permeable membrane-covered co-composting: Humification and microbial community succession.

This study focused on the impacts of heterogeneous Fenton-like pretreatment on the humification and bacterial community during co-composting of wheat straw with cattle dung covered with a semi-permeable membrane. In this study, FeOCl and low concentration of H2O2 were used for pretreatment and composting, which lasted for 39 days. The results showed that the pretreatment promoted the humification process, with degree of polymerization and percentage of humic acid increasing by 53.2 % and 7.3 %, respectively. Furthermore, the diversity and structure of bacterial communities were altered by pretreatment. During the thermophilic phase, pretreatment considerably promoted the metabolism of carbohydrate. According to redundancy analysis, C/N, moisture and organic matter were the key environmental factors that dominated the microbial community. In summary, heterogeneous Fenton-like pretreatment provided a novel idea for improving the humic acid content and maturity of the compost pile.

Enhancement of methane production from anaerobic digestion of Erigeron canadensis via O2-nanobubble water supplementation.

Malignant invasive Erigeron canadensis, as a typical lignocellulosic biomass, is a formidable challenge for sustainable and efficient resource utilization, however nanobubble water (NBW) coupled with anaerobic digestion furnishes a prospective strategy with superior environmental and economic effectiveness. In this study, influence mechanism of various O2-NBW addition times on methanogenic performance of E. canadensis during anaerobic digestion were performed to achieve the optimal pollution-free energy conversion. Results showed that supplementation of O2-NBW in digestion system could significantly enhance the methane production by 10.70-16.17%, while the maximum cumulative methane production reached 343.18 mL g-1 VS in the case of one-time O2-NBW addition on day 0. Furthermore, addition of O2-NBW was conducive to an increase of 2-90% in the activities of dehydrogenase, α-glucosidase and coenzyme F420. Simultaneously, both facultative bacteria and methanogenic archaea were enriched as well, further indicating that O2-NBW might be responsible for facilitating hydrolytic acidification and methanogenesis. Based on Kyoto Encyclopedia of Genes and Genomes (KEGG) cluster analysis, provision of O2-NBW enhanced the metabolism of carbohydrate and amino acid, translation as well as membrane transport of bacteria and archaea. This study might offer the theoretical guidance and novel insights for efficient recovery of energy from lignocellulosic biomass on account of O2-NBW adhibition in anaerobic digestion system, progressing tenor of carbon-neutral vision.

Pyrolytic homogeneity enhancement of municipal solid waste using a clustering-based sorting strategy.

Heterogeneity of pyrolytic parameters in municipal solid waste (MSW) significantly hinders its waste-to-energy efficiency. So far, hardly any light has been shed on current pyrolytic heterogeneity conditions or feasible pyrolytic homogeneity enhancement approaches of MSW. Accordingly, pyrolytic properties (Ea and logA) of 130 MSW samples in 6 categories were collected from literature. A kinetic parameters clustering-based sorting strategy for MSW was proposed. A so-called C index was established to compare their sorting performance for Ea and logA against two traditional sorting strategies (substance categorization and density clustering). Results showed that the proposed sorting strategies outperformed the traditional ones in pyrolytic homogeneity enhancement, where the optimal C_Ea and C_logA reached 1578.30 kJ/mol and 93.11 -log min. Among investigated clustering methods, k-means clustering outperformed hierarchical clustering, which could be attributed to its adaptability to the sample structure. Future perspectives involving data set expansion, model framework development, and downstream technologies matching were also discussed. The index C established in this study can be used to evaluate other clustering models.

Integrated serum pharmacochemistry and investigation of the anti-influenza A virus pneumonia effect of Qingjin Huatan decoction.

ETHNOPHARMACOLOGICAL RELEVANCE: Qingjin Huatan Decoction (QJHTT) consists of 11 herbal medicines: Scutellaria baicalensis Georgi, Gardenia jasminoides J. Ellis, Platycodon grandiflorus (Jacq.) A. DC., Ophiopogon japonicus (Thunb.) Ker Gawl., Morus alba L., Fritillaria thunbergii Miq., Anemarrhena asphodeloides Bunge, Trichosanthes kirilowii Maxim., Citrus reticulata Blanco, Poria cocos (Schw.) Wolf, and Glycyrrhiza uralensis Fisch. As a traditional Chinese medicinal formula, QJHTT has been used for more than 400 years in China. It has shown promising results in treating influenza A virus (IAV) pneumonia. AIM OF THE STUDY: To elusive the specific pharmacological constituents and mechanisms underlying its anti-IAV pneumonia effects. MATERIALS AND METHODS: The components in QJHTT were analyzed through the use of a serum pharmacology-based ultra high-performance liquid chromatography Q- Exactive Orbitrap mass spectrometry (UHPLC-Q Exactive Orbitrap-MS) method. Simultaneously, the dynamic changes in IAV-infected mouse lung viral load, lung index, and expression of lung inflammation factors were monitored by qRT-PCR. RESULTS: We successfully identified 152 chemical components within QJHTT, along with 59 absorbed chemical prototype constituents found in the serum of mice treated with QJHTT. 43.45% of these chemical components and 43.10% of the prototype constituents were derived from the monarch drugs, namely Huangqin and Zhizi, aligning perfectly with traditional Chinese medicine theory. Notably, our analysis led to the discovery of 14 compounds within QJHTT for the first time, three of which were absorbed into the bloodstream. Simultaneously, we observed that QJHTT not only reduced the viral load but also modulated the expression of inflammation factors in the lung tissue including TNF-α, IL-1ß, IL-4, IL-6, IFN-γ, and IL17A. A time-effect analysis further revealed that QJHTT intervention effectively suppressed the peak of inflammatory responses, demonstrating a robust anti-IAV pneumonia effect. CONCLUSIONS: We comprehensively analyzed the pharmacological material basis of QJHTT by a highly sensitive and high-resolution UHPLC-Q Exactive Orbitrap-MS method, and demonstrated its efficacy in combating IAV pneumonia by reducing lung viral load and inflammatory factors. This study has significant importance for elucidating the pharmacological basis and pharmacological mechanism of QJHTT in combating IAV pneumonia.