RESUMO
Cephalosol (1), a potent antimicrobial secondary metabolite with a new carbon skeleton, was characterized from the culture of Cephalosporium acremonium IFB-E007 that used to reside as an endophyte in Trachelospermum jasminoides (Apocynaceae). Its structure and absolute configuration were unambiguously determined by spectroscopic and computational approaches.
Assuntos
Acremonium/química , Anti-Infecciosos/química , Compostos Heterocíclicos com 3 Anéis/química , Extratos Vegetais/química , Anti-Infecciosos/metabolismo , Anti-Infecciosos/farmacologia , Apocynaceae/química , Candida albicans/efeitos dos fármacos , Simulação por Computador , Escherichia coli/efeitos dos fármacos , Compostos Heterocíclicos com 3 Anéis/metabolismo , Compostos Heterocíclicos com 3 Anéis/farmacologia , Espectroscopia de Ressonância Magnética/métodos , Espectroscopia de Ressonância Magnética/normas , Testes de Sensibilidade Microbiana , Modelos Químicos , Extratos Vegetais/metabolismo , Extratos Vegetais/farmacologia , Raízes de Plantas/química , Pseudomonas fluorescens/efeitos dos fármacos , Padrões de Referência , Trichophyton/efeitos dos fármacosRESUMO
OBJECTIVE: To evaluate the clinical characteristics and long-term outcome of 310 cases of thymectomy for myasthenia Gravis. METHODS: The data of 310 patients with thymectomy were analyzed retrospectively to study the patient selection, operative techniques, perioperative management and results for myasthenia Gravis. Absolute and relative scores for clinical evaluation were used as the criteria to determine the therapeutic effects of thymectomy. RESULTS: There were no operative death and postoperative complication rates were 8.7% (27/310). The extra anatomic thymic tissue was found in up to 38.7% (120/310) patients and thymus hyperplasia occurred in 92.9% (288/310) cases. 92.6% (287/310) postoperative patients were followed up for 3 or more months; the percentage of patients being remitted, essentially remitted, significantly effective, effective and non-effective were 7.1% (22/310), 11.3% (35/310) 40.0% (124/310), 27.1% (84/310), 7.1% (22/310) respectively. The total long-term effective rate was 85.5% (265/310). The effective rate for type I, IIa, IIb, III, IV was 90.9% (20/22), 97.6% (40/41), 95.3% (162/170), 80.6% (29/36), 77.8% (14/18) respectively. CONCLUSIONS: Generalized typed and properly selected recurrent ocular-typed patients with Myasthenia Gravis undergoing extensive thymectomy would have good long-term outcomes.