Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

A White-Box Machine Learning Approach for Revealing Antibiotic Mechanisms of Action.

Yang, Jason H; Wright, Sarah N; Hamblin, Meagan; McCloskey, Douglas; Alcantar, Miguel A; Schrübbers, Lars; Lopatkin, Allison J; Satish, Sangeeta; Nili, Amir; Palsson, Bernhard O; Walker, Graham C; Collins, James J.

Cell ; 177(6): 1649-1661.e9, 2019 05 30.

Artigo em Inglês | MEDLINE | ID: mdl-31080069

2.

Applications of Machine Learning to the Problem of Antimicrobial Resistance: an Emerging Model for Translational Research.

Anahtar, Melis N; Yang, Jason H; Kanjilal, Sanjat.

J Clin Microbiol ; 59(7): e0126020, 2021 06 18.

Artigo em Inglês | MEDLINE | ID: mdl-33536291

3.

Lethality of MalE-LacZ hybrid protein shares mechanistic attributes with oxidative component of antibiotic lethality.

Takahashi, Noriko; Gruber, Charley C; Yang, Jason H; Liu, Xiaobo; Braff, Dana; Yashaswini, Chittampalli N; Bhubhanil, Sakkarin; Furuta, Yoshikazu; Andreescu, Silvana; Collins, James J; Walker, Graham C.

Proc Natl Acad Sci U S A ; 114(34): 9164-9169, 2017 Aug 22.

Artigo em Inglês | MEDLINE | ID: mdl-28794281

4.

CRISP(e)R drug discovery.

Yang, Jason H.

Nat Chem Biol ; 18(5): 435-436, 2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-35197625

5.

Antibiotic efficacy is linked to bacterial cellular respiration.

Lobritz, Michael A; Belenky, Peter; Porter, Caroline B M; Gutierrez, Arnaud; Yang, Jason H; Schwarz, Eric G; Dwyer, Daniel J; Khalil, Ahmad S; Collins, James J.

Proc Natl Acad Sci U S A ; 112(27): 8173-80, 2015 Jul 07.

Artigo em Inglês | MEDLINE | ID: mdl-26100898

6.

Quantification of DNA by a Thermal-Durable Biosensor Modified with Conductive Poly(3,4-ethylenedioxythiophene).

Gu, Yesong; Tseng, Po-Yuan; Bi, Xiang; Yang, Jason H C.

Sensors (Basel) ; 18(11)2018 Oct 30.

Artigo em Inglês | MEDLINE | ID: mdl-30380711

7.

Antibiotics induce redox-related physiological alterations as part of their lethality.

Dwyer, Daniel J; Belenky, Peter A; Yang, Jason H; MacDonald, I Cody; Martell, Jeffrey D; Takahashi, Noriko; Chan, Clement T Y; Lobritz, Michael A; Braff, Dana; Schwarz, Eric G; Ye, Jonathan D; Pati, Mekhala; Vercruysse, Maarten; Ralifo, Paul S; Allison, Kyle R; Khalil, Ahmad S; Ting, Alice Y; Walker, Graham C; Collins, James J.

Proc Natl Acad Sci U S A ; 111(20): E2100-9, 2014 May 20.

Artigo em Inglês | MEDLINE | ID: mdl-24803433

8.

PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to ß-adrenergic signaling.

Yang, Jason H; Polanowska-Grabowska, Renata K; Smith, Jeffrey S; Shields, Charles W; Saucerman, Jeffrey J.

J Mol Cell Cardiol ; 66: 83-93, 2014 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-24225179

9.

Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP.

Sample, Vedangi; DiPilato, Lisa M; Yang, Jason H; Ni, Qiang; Saucerman, Jeffrey J; Zhang, Jin.

Nat Chem Biol ; 8(4): 375-82, 2012 Feb 26.

Artigo em Inglês | MEDLINE | ID: mdl-22366721

10.

Computational models reduce complexity and accelerate insight into cardiac signaling networks.

Yang, Jason H; Saucerman, Jeffrey J.

Circ Res ; 108(1): 85-97, 2011 Jan 07.

Artigo em Inglês | MEDLINE | ID: mdl-21212391

11.

An in vitro model of the macrophage-endothelial interface to characterize CAR T-cell induced cytokine storm.

Rosen, Robert S; Yang, Jason H; Peña, Juan S; Schloss, Rene; Yarmush, Martin L.

Sci Rep ; 13(1): 18835, 2023 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-37914765

12.

Phospholemman is a negative feed-forward regulator of Ca2+ in ß-adrenergic signaling, accelerating ß-adrenergic inotropy.

Yang, Jason H; Saucerman, Jeffrey J.

J Mol Cell Cardiol ; 52(5): 1048-55, 2012 May.

Artigo em Inglês | MEDLINE | ID: mdl-22289214

13.

A comprehensive update to the Mycobacterium tuberculosis H37Rv reference genome.

Chitale, Poonam; Lemenze, Alexander D; Fogarty, Emily C; Shah, Avi; Grady, Courtney; Odom-Mabey, Aubrey R; Johnson, W Evan; Yang, Jason H; Eren, A Murat; Brosch, Roland; Kumar, Pradeep; Alland, David.

Nat Commun ; 13(1): 7068, 2022 11 18.

Artigo em Inglês | MEDLINE | ID: mdl-36400796

14.

Longitudinal Analysis of Biologic Correlates of COVID-19 Resolution: Case Report.

Bruiners, Natalie; Guerrini, Valentina; Ukey, Rahul; Dikdan, Ryan J; Yang, Jason H; Mishra, Pankaj Kumar; Onyuka, Alberta; Handler, Deborah; Vieth, Joshua; Carayannopoulos, Mary; Guo, Shuang; Pollen, Maressa; Pinter, Abraham; Tyagi, Sanjay; Feingold, Daniel; Philipp, Claire; Libutti, Steven K; Gennaro, Maria Laura.

Front Med (Lausanne) ; 9: 915367, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35783607

15.

Digital Insights Into Nucleotide Metabolism and Antibiotic Treatment Failure.

Lopatkin, Allison J; Yang, Jason H.

Front Digit Health ; 32021 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-34355212

16.

Growth and Stress Tolerance Comprise Independent Metabolic Strategies Critical for Staphylococcus aureus Infection.

Kim, Gyu-Lee; Hooven, Thomas A; Norambuena, Javiera; Li, Barry; Boyd, Jeffrey M; Yang, Jason H; Parker, Dane.

mBio ; 12(3): e0081421, 2021 06 29.

Artigo em Inglês | MEDLINE | ID: mdl-34101490

17.

Clinically relevant mutations in core metabolic genes confer antibiotic resistance.

Lopatkin, Allison J; Bening, Sarah C; Manson, Abigail L; Stokes, Jonathan M; Kohanski, Michael A; Badran, Ahmed H; Earl, Ashlee M; Cheney, Nicole J; Yang, Jason H; Collins, James J.

Science ; 371(6531)2021 02 19.

Artigo em Inglês | MEDLINE | ID: mdl-33602825

18.

Bacterial metabolic state more accurately predicts antibiotic lethality than growth rate.

Lopatkin, Allison J; Stokes, Jonathan M; Zheng, Erica J; Yang, Jason H; Takahashi, Melissa K; You, Lingchong; Collins, James J.

Nat Microbiol ; 4(12): 2109-2117, 2019 12.

Artigo em Inglês | MEDLINE | ID: mdl-31451773

19.

Antibiotic efficacy-context matters.

Yang, Jason H; Bening, Sarah C; Collins, James J.

Curr Opin Microbiol ; 39: 73-80, 2017 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-29049930

20.

Antibiotic-Induced Changes to the Host Metabolic Environment Inhibit Drug Efficacy and Alter Immune Function.

Yang, Jason H; Bhargava, Prerna; McCloskey, Douglas; Mao, Ning; Palsson, Bernhard O; Collins, James J.

Cell Host Microbe ; 22(6): 757-765.e3, 2017 Dec 13.

Artigo em Inglês | MEDLINE | ID: mdl-29199098

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