RESUMO
A simple one-step method for preparing biocompatible nanoparticles of gadolinium ferrocyanide coordination polymer KGd(H2O)2[Fe(CN)6]·H2O is reported. The crystal structure of this coordination polymer is determined by X-ray powder diffraction using the bulk materials. The stability, cytotoxicity, cellular uptake, and MR phantom and cellular imaging studies suggest that this coordination-polymer structural platform offers a unique opportunity for developing the next generation of T1-weighted contrast agents with high relaxivity as cellular MR probes for biological receptors or markers. Such high-relaxivity MR probes may hold potential in the study of molecular events and may be used for in vivo MR imaging in biomedical research and clinical applications.
Assuntos
Materiais Biocompatíveis/química , Meios de Contraste/química , Complexos de Coordenação/química , Ferrocianetos/química , Gadolínio/química , Animais , Cristalografia por Raios X , Humanos , Imageamento por Ressonância Magnética , Imagem Molecular/instrumentação , Imagem Molecular/métodos , Nanopartículas/química , Nanopartículas/ultraestrutura , Imagens de Fantasmas , Água/químicaRESUMO
The gallium analogue of the soluble Prussian blue with the formula KGa[Fe(CN)6]·nH2O is synthesized and structurally characterized. A simple aqueous synthetic procedure for preparing nanoparticles of this novel coordination polymer is reported. The stability, in vitro ion exchange with ferrous ions, cytotoxicity, and cellular uptake of such nanoparticles coated with poly(vinylpyrrolidone) are investigated for potential applications of delivering Ga(3+) ions into cells or removing iron from cells.