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1.
Med Princ Pract ; 31(6): 524-531, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36215953

RESUMO

OBJECTIVE: Extrahepatic portal vein thrombosis (EHPVT) is a common cause of portal hypertension in children. The aim of the present study was to identify the clinical manifestations and the risk factors for development of EHPVT in pediatric patients. SUBJECTS AND METHODS: This was a single-center retrospective cohort study. A total of 12 children (6 boys and 6 girls) took part in the study. We noted the clinical presentations and the predisposing risk factors for development of EHPVT in all patients. In addition, as all of them had undergone an esophagogastroduodenoscopy for detection and grading of esophageal varices as part of the treatment algorithm, we analyzed the endoscopic findings and the therapeutic approach. RESULTS: The median age of subjects at diagnosis was 3.5 years (range: 1-17 years). The most frequent initial clinical manifestation was upper gastrointestinal bleeding (6 cases, 50.0%) followed by splenomegaly (3 cases, 25.0%). The most frequent systemic risk factor for EHPVT was presence of inherited prothrombotic disorder (10 cases, 83.3%), and the most common local risk factor for EHPVT was umbilical vein catheterization (5 cases, 41.7%). Esophageal varices were revealed in all the study participants, and in the most cases, they were grade ≥2. Propranolol was used as primary or secondary prophylaxis in 7 children (58.3%), and in 5 children (41.7%), a shunt was performed (Meso-Rex bypass in 3 children and splenorenal shunt in 2 children). CONCLUSION: Patients with known systemic or local risk factors for EHPVT are indicated for proactive ultrasound screening for early diagnosis and timely management.


Assuntos
Varizes Esofágicas e Gástricas , Trombose Venosa , Masculino , Feminino , Criança , Humanos , Lactente , Pré-Escolar , Adolescente , Veia Porta , Varizes Esofágicas e Gástricas/terapia , Varizes Esofágicas e Gástricas/complicações , Estudos Retrospectivos , Trombose Venosa/epidemiologia , Trombose Venosa/terapia , Fatores de Risco , Hemorragia Gastrointestinal/epidemiologia , Hemorragia Gastrointestinal/etiologia , Hemorragia Gastrointestinal/prevenção & controle
2.
Folia Med (Plovdiv) ; 59(3): 303-309, 2017 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-28976902

RESUMO

BACKGROUND: There is no specific toxicological screening of clinical laboratory parameters in clinical toxicology when it comes to acute exogenous poisoning. AIM: To determine routine clinical laboratory parameters and indicators for assessment of vital functions in patients with acute intoxications. MATERIALS AND METHODS: One hundred and fifty-three patients were included in the present study. They were hospitalized in the Department of Clinical Toxicology at St. George University Hospital, Plovdiv for cerebral toxicity inducing medication (n = 45), alcohol (n = 40), heroin abuse (n = 33). The controls were 35. The laboratory tests were conducted in compliance with the standards of the clinical laboratory. We used the following statistical analyses: analysis of variance (the ucriterion of normal distribution, the Student's t-test, dispersion analysis based on ANOVA) and non-parametric analysis. RESULTS AND DISCUSSION: Based on the routine hematological parameters with statistically significant changes in three groups of poisoning are: red blood cells, hematocrit, hemoglobin (except alcohol intoxication) and leukocytes. We found statistically significant changes in serum total protein, sodium and bilirubin. The highest statistical significance is the increased activity of AST and ALT. CONCLUSION: We present a model for selection of clinical laboratory tests for severe acute poisoning with modern equipment under standardized conditions. The results of the study suggest that the clinical laboratory constellation we used can be used as a mandatory element in the diagnosis of moderate and severe intoxication with the mentioned toxic substances.


Assuntos
Alcoolismo/diagnóstico , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/diagnóstico , Dependência de Heroína/diagnóstico , Intoxicação/diagnóstico , Doença Aguda , Adulto , Alcoolismo/epidemiologia , Bulgária/epidemiologia , Estudos de Casos e Controles , Técnicas de Laboratório Clínico , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia , Feminino , Dependência de Heroína/epidemiologia , Hospitalização/estatística & dados numéricos , Hospitais Universitários , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Intoxicação/epidemiologia , Estudos Retrospectivos , Medição de Risco , Análise de Sobrevida
3.
Folia Med (Plovdiv) ; 56(2): 126-8, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25181850

RESUMO

Lower gastrointestinal bleeding is a rare condition in childhood pathology. The incidence of this disorder in the general population of Bulgarian children is unknown. We report a case of a 7-year-old child with diagnosed hemophilia A and high titer of factor VIII inhibitor; the patient was admitted into the Department of Pediatrics and Medical Genetics for rectorrhagia after falling onto his buttocks while playing. Colonoscopy showed submucosal hematoma 25 cm from the anocutaneous line occluding the intestinal lumen with a lesion of the overlying mucosa as long as 20 mm. If a patient presents with rectorrhagia, timely and carefully planned colonoscopy could identify the source of bleeding, determine the severity of bleeding and the size of hematoma, and assess the need for surgical intervention. The reported case supports the modern view that patients with inhibitor hemophilia should not be denied interventional procedure or surgical intervention for fear of uncontrolled bleeding.


Assuntos
Colonoscopia , Hematoma/diagnóstico , Hematoma/etiologia , Hemofilia A/complicações , Doenças do Colo Sigmoide/diagnóstico , Doenças do Colo Sigmoide/etiologia , Criança , Diagnóstico Diferencial , Hematoma/terapia , Humanos , Masculino , Doenças do Colo Sigmoide/terapia
4.
Folia Med (Plovdiv) ; 55(3-4): 87-9, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24712288

RESUMO

Celiac disease and cystic fibrosis share a number of clinical manifestations. The comorbidity rate of these diseases is low: 1:200000. We present a case of a child aged 1 year and 5 months, born to a mixed-marriage parents, with concomitant cystic fibrosis and celiac disease manifesting initially with chronic diarrhea. Diagnosis of cystic fibrosis was made on the basis of changes in pulmonogram and three positive sweat tests with the malabsorption managed. Celiac disease was demonstrated through immunological tests (serological test of anti-transglutaminase antibodies of IgA class), histological tests (altered duodenal mucosa) and the therapeutic effect of a gluten-free diet. This case is the first ever reported case of a child with concomitant cystic fibrosis and celiac disease in Bulgaria. The case suggests the need for targeted screening for celiac disease in children with cystic fibrosis.


Assuntos
Doença Celíaca/complicações , Fibrose Cística/complicações , Humanos , Lactente , Masculino
5.
Folia Med (Plovdiv) ; 65(1): 166-170, 2023 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-36855990

RESUMO

Cytomegalovirus is widely spread worldwide, and it is not uncommon for it to complicate the congenital human immunodeficiency virus (HIV) disease as an acquired or congenital coinfection. However, the association of the two infections is not common amongst infants with primary immune deficiencies.We describe a case of a 6-month-old infant with acquired cytomegalovirus and HIV infections, diagnosed in the course of the patient's clinical and laboratory workup for a presumed primary immunodeficiency. To date, this is the first reported case of such a combination in a child from Bulgaria.


Assuntos
Síndrome da Imunodeficiência Adquirida , Infecções por Citomegalovirus , Infecções por HIV , Criança , Humanos , Lactente , Infecções por HIV/complicações , Infecções por HIV/diagnóstico , Citomegalovirus , Infecções por Citomegalovirus/complicações , Infecções por Citomegalovirus/diagnóstico , Bulgária
6.
Folia Med (Plovdiv) ; 65(3): 490-494, 2023 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-38351827

RESUMO

The epiphrenic esophageal diverticulum is a rare non-malignant condition that is commonly associated with motility disorders. It would normally be treated surgically, but with the advancement of endoscopy techniques, peroral endoscopic myotomy with septotomy (D-POEM) has shown its benefits in coping with the symptoms. We present a case of a 71-year-old woman with increasing symptoms of dysphagia, weight loss and imaging data showing a large epiphrenic diverticulum. We treated her using peroral endoscopic myotomy combined with septotomy of the diverticular septum. The procedure showed excellent results with reducing the amount of contrast materials retained in it, improving the quality of life of the patient, and increasing her weight. There were minimal adverse events and no perforations or severe adverse effects occurred. D-POEM is a new and rapidly evolving procedure that is proving to be a safe and effective method of treating epiphrenic esophageal diverticulum.


Assuntos
Procedimentos Cirúrgicos do Sistema Digestório , Divertículo Esofágico , Miotomia , Humanos , Feminino , Idoso , Qualidade de Vida , Miotomia/efeitos adversos , Miotomia/métodos , Divertículo Esofágico/cirurgia , Divertículo Esofágico/diagnóstico , Divertículo Esofágico/etiologia , Esôfago , Resultado do Tratamento
7.
Folia Med (Plovdiv) ; 54(1): 5-11, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22908824

RESUMO

Ventilator-associated pneumonias have been estimated to be the second most common nosocomial infections among children treated in intensive care units. They occur in mechanically ventilated patients through intubation tube or tracheostomy, the inflammation usually involving the lung parenchyma. The ventilator-associated pneumonia is associated with a longer antibiotic treatment, greater duration of mechanical ventilation (MV) and higher mortality rates in children. The condition is also associated with a higher cost of the treatment. This paper reviews and comments in detail the criteria formulated by the National Nosocomial Infection Surveillance (NNSI) and the Centers for Disease Control and Prevention (CDC) for diagnosis of ventilator-associated pneumonias in children. The disease etiology is associated with the typical causes of nosocomial infections in this age: P. aeruginosa, E. coli and K. pneumoniae. The pathogenesis of the condition is inadequately studied but the aspiration of gastric contents and immune deficiency are proven risk factors. Two mechanisms have a major role in the development of the disease--micro-aspiration of gastric contents and colonization of the lower airways with pathogens.


Assuntos
Pneumonia Associada à Ventilação Mecânica/diagnóstico , Pneumonia Associada à Ventilação Mecânica/etiologia , Criança , Humanos , Radiografia Torácica , Fatores de Risco
8.
Folia Med (Plovdiv) ; 54(1): 12-8, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22908825

RESUMO

Ventilator-associated pneumonia (VAP) is the second most common nosocomial infection among children treated in intensive care units. The risk factors for developing this condition are generated by the patient's bedside conditions, the equipment used and the specific treatment administered to the child. Prophylaxis of VAP should necessarily include all measures that have been proven to be efficient in this respect such as rigorous hygiene control of hands and protective clothing of attending staff, changing breathing circuits of ventilators only if they malfunction or if they are visibly contaminated, preference of orotracheal intubation (instead of nasotracheal intubation) and use of endotracheal tubes with dorsal lumens to allow respiratory secretions to drain, and introduction of a uniform approach to patient care and staff training. Prophylaxis of the microbial colonization in children by antibiotics does not reduce the incidence of VAP-causing poly-resistant bacteria. Therapeutic management includes early initiation of broad spectrum empirical antibiotic therapy, the right choice of antibiotic requiring regular monitoring and good knowledge of the antibiotics sensitivity of the most common microbial isolates in the ward.


Assuntos
Pneumonia Associada à Ventilação Mecânica/prevenção & controle , Pneumonia Associada à Ventilação Mecânica/terapia , Antibacterianos/uso terapêutico , Criança , Humanos
9.
Turk J Pediatr ; 64(3): 599-603, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35899576

RESUMO

BACKGROUND: Intrapancreatic accessory spleen is a congenital abnormality with duplicated splenic tissue located in ectopic sites. CASE: We report a case of 10-year-old male patient with an infrequent finding of intrapancreatic mass. The examination of complete blood count, biochemistry, tumor markers were within the normal reference ranges. Imaging series found an intrapancreatic mass without wash-out effect on contrast-enhanced ultrasound, MRIintensity equal to splenic one and no increased glucose metabolism on PET/CT. Follow-up of the patient did not demonstrate progression of the size or change of ultrasound characteristics of the lesion. CONCLUSIONS: Intrapancreatic accessory spleen is an asymptomatic lesion and without the need of surgical therapy. It is important to differentiate it from pancreatic malignant tumors.


Assuntos
Coristoma , Anormalidades do Sistema Digestório , Pancreatopatias , Criança , Coristoma/diagnóstico por imagem , Coristoma/cirurgia , Diagnóstico Diferencial , Humanos , Masculino , Pancreatopatias/diagnóstico por imagem , Pancreatopatias/cirurgia , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Baço/diagnóstico por imagem
10.
Folia Med (Plovdiv) ; 64(1): 152-155, 2022 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-35851894

RESUMO

The purpose of the study was to present a rare case of post-traumatic Parinaud's syndrome with a history of closed head injury. The clinical characteristics, examination, and management are presented in a 12-year-old boy who was a victim of physical violence at the hands of a young boy who punched him in his chin with his fists, with associated paralysis of the upward gaze of the left eyeball, and convergence nystagmus with pupillary involvement. CT examination indicated posttraumatic lesions in the dorsal midbrain and in the cavity of third ventricle, suggestive of acute hemorrhages. Posttraumatic Parinaud's syndrome is a rare phenomenon that can occur in a case of closed head trauma as contrecoup injury.


Assuntos
Lesão de Contragolpe , Traumatismos Cranianos Fechados , Transtornos da Motilidade Ocular , Criança , Traumatismos Cranianos Fechados/complicações , Humanos , Masculino
11.
J Ultrason ; 22(88): e64-e66, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35449699

RESUMO

Gallbladder polyps are a relatively rare finding in children. The increased use of high-resolution ultrasound in childhood allows to detect gallbladder lesions in young patients. A precise diagnosis can be established using different imaging series. Abdominal contrast-enhanced ultrasound examination provides the most accurate imaging information about the nature and size of the lesion. This is important for further decisions regarding patient referral for cholecystectomy. The object of this study was to present a case of gallbladder polyp diagnosed and followed up by contrast-enhanced ultrasound.

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