RESUMO
We determined and compared the levels of BHC and DDT isomers and metabolites and HCB in the adipose tissue of 82 cases of autopsies performed at the Morgue Department of Adana Branch of the Council of Forensic Medicine. The relationships between the age, gender, and body mass indexes of cases, and the accumulation of OCs residues were also investigated. Detectable concentrations of p,p'-DDE were found in 100% of adipose tissue samples. Concentrations of OCs in female adipose tissues were significantly higher than male adipose tissues (p < 0.05). The presented work is highly significant, being the first study pointing out the chronic exposure to organochlorine pesticides in Cukurova region.
Assuntos
Tecido Adiposo/metabolismo , Exposição Ambiental/análise , Hidrocarbonetos Clorados/análise , Resíduos de Praguicidas/análise , Tecido Adiposo/química , Adolescente , Adulto , Fatores Etários , Idoso , Índice de Massa Corporal , Cadáver , Canadá , Cromatografia Gasosa , Cidades , DDT/análise , DDT/química , DDT/metabolismo , Diclorodifenil Dicloroetileno/análise , Diclorodifenil Dicloroetileno/química , Diclorodifenil Dicloroetileno/metabolismo , Europa (Continente) , Feminino , Hexaclorobenzeno/análise , Hexaclorobenzeno/química , Hexaclorobenzeno/metabolismo , Humanos , Índia , Masculino , Pessoa de Meia-Idade , Fatores Sexuais , América do Sul , Fatores de Tempo , Turquia , Estados Unidos , Adulto JovemRESUMO
The stability of drugs in formalin solution is an important factor in forensic investigation. Tissues (liver, lung, kidney, brain) taken from rats, which have been poisoned acutely with cocaine, were preserved in two different conditions, analyzed by GC-MS, and then compared. Organs of the first group were preserved and stored at -20 degrees C without adding formalin, whereas the organs of the second group were preserved and stored in formalin solution at room temperature (25 degrees C). Serum samples were taken immediately after poisoning and studied as well. In specimens stored at -20 degrees C, cocaine and its metabolite benzoylecgonine were detected in the tissues. Only benzoylecgonine was detected both in tissues and their formalin solution. It was observed that the distribution of cocaine in tissues had differed depending on the preservation conditions. The formalin solution in which benzoylecgonine was mostly detected was from liver. As a result, cocaine was detected in tissues stored at -20 degrees C. It is recommended that both the formalin-fixed tissues and formalin solution should be analyzed concurrently to assure the accurate results (LOD = 3 ng/ml).
Assuntos
Cocaína/análogos & derivados , Cocaína/análise , Fixadores , Toxicologia Forense/métodos , Formaldeído , Detecção do Abuso de Substâncias/métodos , Animais , Cromatografia Gasosa-Espectrometria de Massas/métodos , Masculino , Ratos , Ratos Wistar , Fixação de Tecidos/métodosRESUMO
In Cukurova region, pesticide poisonings still remain an unfortunate cause of death, which led to the present study. The autopsy records of Adana Branch of the Council of Forensic Medicine, between 2006 and 2008, were evaluated retrospectively. Deaths that were attributed to pesticide poisoning were included in the scope of the study to identify the type of pesticide, and etiology of intoxication. The frequency and distribution of intoxications were also analyzed in terms of sex and age. In the studied period, a total of 4199 autopsies were referred to the forensic toxicology laboratory for pesticide analysis. Seventy-two cases were positive for pesticide analysis. Of these, 42 (58.33%) were male and 30 (41.67%) were female, with a mean age of 38.8 ± 20.6 years. Among the inspected pesticides, endosulfan was found to be the most common with 47.2% of prevalence, followed by dichlorvos. This report showed that certain pesticides, endosulfan in particular, remains as common cause of poisonings in Cukurova region.