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1.
J Prosthodont ; 23(2): 124-33, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23734561

RESUMO

PURPOSE: To evaluate the effect of two putty-wash impression techniques on the long-term accuracy and dimensional stability of poly(vinyl siloxane) (PVS) in the gingival sulcus area. MATERIALS AND METHODS: Impressions were taken from a master cast to simulate molar crown preparation. A space around the abutment served as the gingival sulcus. Fifteen impressions using the one- and two-step impression techniques were taken using Express Regular, Express Fast, and President impression materials with custom trays. Using a Toolmaker's microscope, the long (LD) and short distances (SD) of the abutment and the planar distance between two parallel lines (PL) at the circumference of the cast were taken at 0.5, 2, 24, 48, 72, 96, 120, and 144 hours after mixing. ANOVA was performed, with the discrepancy between the distances of the impressions and the master cast as the dependent variable. RESULTS: The differences when different materials and impression techniques were used were significant (p < 0.001) for LD, SD, and PL, as was the interaction between the material, time, and technique (p < 0.001). SD discrepancies were higher than those of LD for all materials and times. The two-step impression technique was more accurate, with smaller discrepancies than the one-step impression technique. For all materials, the PL discrepancy was deemed acceptable (less than 0.5%) for all tested times. President had higher discrepancies than the other materials. CONCLUSIONS: When using the two-step putty-wash impression technique, pouring of the impressions may be postponed up to 30 hours; however, when using the one-step impression technique, pouring should be performed within 2 hours.


Assuntos
Materiais para Moldagem Odontológica/normas , Técnica de Moldagem Odontológica/normas , Gengiva/anatomia & histologia , Polivinil/normas , Siloxanas/normas , Dente Suporte/normas , Materiais para Moldagem Odontológica/química , Técnica de Moldagem Odontológica/instrumentação , Humanos , Teste de Materiais , Dente Molar/anatomia & histologia , Polivinil/química , Silicones/química , Siloxanas/química , Propriedades de Superfície , Fatores de Tempo , Preparo Prostodôntico do Dente/normas
2.
Mov Disord ; 28(14): 1966-71, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24243757

RESUMO

The phenotype of Parkinson's disease (PD) in patients with and without leucine-rich repeat kinase 2 (LRRK2) G2019S mutations reportedly is similar; however, large, uniformly evaluated series are lacking. The objective of this study was to characterize the clinical phenotype of Ashkenazi Jewish (AJ) PD carriers of the LRRK2 G2019S mutation. We studied 553 AJ PD patients, including 65 patients who were previously reported, from three sites (two in New York and one in Tel-Aviv). Glucocerebrosidase (GBA) mutation carriers were excluded. Evaluations included the Montreal Cognitive Assessment (MoCA), the Unified Parkinson's Disease Rating Scale (UPDRS), the Geriatric Depression Scale (GDS) and the Non-Motor Symptoms (NMS) questionnaire. Regression models were constructed to test the association between clinical and demographic features and LRRK2 status (outcome) in 488 newly recruited participants. LRRK2 G2019S carriers (n = 97) and non-carriers (n = 391) were similar in age and age at onset of PD. Carriers had longer disease duration (8.6 years vs. 6.1 years; P < 0.001), were more likely to be women (51.5% vs. 37.9%; P = 0.015), and more often reported first symptoms in the lower extremities (40.0% vs. 19.2%; P < 0.001). In logistic models that were adjusted for age, disease duration, sex, education, and site, carriers were more likely to have lower extremity onset (P < 0.001), postural instability and gait difficulty (PIGD) (P = 0.043), and a persistent levodopa response for >5 years (P = 0.042). Performance on the UPDRS, MoCA, GDS, and NMS did not differ by mutation status. PD in AJ LRRK2 G2019S mutation carriers is similar to idiopathic PD but is characterized by more frequent lower extremity involvement at onset and PIGD without the associated cognitive impairment.


Assuntos
Glicina/genética , Mutação/genética , Doença de Parkinson/genética , Proteínas Serina-Treonina Quinases/genética , Serina/genética , Idoso , Feminino , Genótipo , Humanos , Judeus/genética , Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina , Masculino , Pessoa de Meia-Idade , Doença de Parkinson/etnologia , Fenótipo , Análise de Regressão , Índice de Gravidade de Doença , Inquéritos e Questionários
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