Detalhe da pesquisa
1.
Inhibition of the angiotensin II type 2 receptor AT2R is a novel therapeutic strategy for glioblastoma.
Proc Natl Acad Sci U S A
; 119(32): e2116289119, 2022 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35917342
2.
Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3.
Mol Pharmacol
; 105(4): 301-312, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38346795
3.
PSW-Designer: An Open-Source Computational Platform for the Design and Virtual Screening of Photopharmacological Ligands.
J Chem Inf Model
; 63(21): 6696-6705, 2023 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37831965
4.
Harnessing Ion-Binding Sites for GPCR Pharmacology.
Pharmacol Rev
; 71(4): 571-595, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31551350
5.
Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor.
Nat Chem Biol
; 15(1): 11-17, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30510194
6.
Publisher Correction: Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor.
Nat Chem Biol
; 15(2): 206, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30573766
7.
Progress in Free Energy Perturbation: Options for Evolving Fragments.
Drug Discov Today Technol
; 40: 36-42, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34916020
8.
Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E4106.30×30K Variant in the Histamine H1 Receptor.
Int J Mol Sci
; 22(7)2021 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33918180
9.
O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity.
J Am Chem Soc
; 141(36): 14210-14219, 2019 09 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31418572
10.
Exploring Pairwise Chemical Crosslinking To Study Peptide-Receptor Interactions.
Chembiochem
; 20(5): 683-692, 2019 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30565820
11.
iPPI-DB: an online database of modulators of protein-protein interactions.
Nucleic Acids Res
; 44(D1): D542-7, 2016 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26432833
12.
Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation.
J Neuroinflammation
; 14(1): 105, 2017 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28494768
13.
Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance.
Proc Natl Acad Sci U S A
; 111(7): 2686-91, 2014 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24492375
14.
Discovery of small molecule CD40-TRAF6 inhibitors.
J Chem Inf Model
; 55(2): 294-307, 2015 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25622654
15.
Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells.
Nat Commun
; 14(1): 1151, 2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36859440
16.
Enzyme-specific activation versus leaving group ability.
Chembiochem
; 13(12): 1785-90, 2012 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22821810
17.
Papain-specific activating esters in aqueous dipeptide synthesis.
Chembiochem
; 13(9): 1319-26, 2012 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22615272
18.
Comparative analysis of pharmacophore screening tools.
J Chem Inf Model
; 52(6): 1607-20, 2012 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22646988
19.
Exploring the Activity Profile of TbrPDEB1 and hPDE4 Inhibitors Using Free Energy Perturbation.
ACS Med Chem Lett
; 13(6): 904-910, 2022 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35707144
20.
Papain-catalyzed peptide bond formation: enzyme-specific activation with guanidinophenyl esters.
Chembiochem
; 12(14): 2201-7, 2011 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21826775