Detalhe da pesquisa
1.
Human visceral adipose tissue microvascular endothelial cell isolation and establishment of co-culture with white adipocytes to analyze cell-cell communication.
Exp Cell Res
; 433(2): 113819, 2023 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37852349
2.
NETosis promotes chronic inflammation and fibrosis in systemic lupus erythematosus and COVID-19.
Clin Immunol
; 254: 109687, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37419296
3.
Metabolic regulation by prostaglandin E2 impairs lung group 2 innate lymphoid cell responses.
Allergy
; 78(3): 714-730, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36181709
4.
Protrudin regulates FAK activation, endothelial cell migration and angiogenesis.
Cell Mol Life Sci
; 79(4): 220, 2022 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35368213
5.
Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer.
Bioorg Med Chem Lett
; 50: 128335, 2021 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34425201
6.
A nanocomposite consisting of etched multiwalled carbon nanotubes, amino-modified metal-organic framework UiO-66 and polyaniline for preconcentration of polycyclic aromatic hydrocarbons prior to their determination by HPLC.
Mikrochim Acta
; 187(1): 78, 2020 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31894420
7.
Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927.
Bioorg Med Chem Lett
; 29(16): 2090-2093, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31311734
8.
Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha.
Bioorg Med Chem Lett
; 29(7): 905-911, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30732944
9.
From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors.
Bioorg Med Chem Lett
; 27(13): 2974-2981, 2017 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28512031
10.
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Bioorg Med Chem Lett
; 27(18): 4370-4376, 2017 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28830649
11.
Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies.
Bioorg Med Chem Lett
; 26(16): 4036-41, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27406798
12.
A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors.
J Immunol
; 191(5): 2205-16, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23894201
13.
HMGA2 knockdown alleviates the progression of nonalcoholic fatty liver disease (NAFLD) by downregulating SNAI2 expression.
Cell Signal
; 109: 110741, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37268162
14.
Serum-derived extracellular vesicles from breast cancer patients contribute to differential regulation of T-cell-mediated immune-escape mechanisms in breast cancer subtypes.
Front Immunol
; 14: 1204224, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37441083
15.
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer.
J Med Chem
; 64(16): 11841-11856, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34251202
16.
A polythiophene/UiO-66 composite coating for extraction of volatile organic compounds migrated from ion-exchange resins prior to their determination by gas chromatography.
J Chromatogr A
; 1633: 461627, 2020 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33128970
17.
Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer.
ACS Med Chem Lett
; 11(6): 1342-1347, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551022
18.
[Relationship between fetal abdominal circumference and birth weight: clinical findings in 1475 pregnancies].
Zhonghua Fu Chan Ke Za Zhi
; 40(11): 732-4, 2005 Nov.
Artigo
em Zh
| MEDLINE | ID: mdl-16324244
19.
Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors.
J Med Chem
; 56(11): 4521-36, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23668484
20.
Lead identification of novel and selective TYK2 inhibitors.
Eur J Med Chem
; 67: 175-87, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23867602