Detalhe da pesquisa
1.
Design, synthesis and evaluation of new pyrimidine derivatives as EGFRC797S tyrosine kinase inhibitors.
Bioorg Med Chem Lett
; 91: 129381, 2023 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37336419
2.
Design, synthesis and bioactivity evaluation of selenium-containing PI3Kδ inhibitors.
Bioorg Chem
; 140: 106815, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37672953
3.
Discovery of potent and selective PI3Kδ inhibitors bearing amino acid fragments.
Bioorg Chem
; 138: 106594, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37186998
4.
Progress of small molecules for targeted protein degradation: PROTACs and other technologies.
Drug Dev Res
; 84(2): 337-394, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36606428
5.
Discovery of novel pyrido[3,2-d]pyrimidine derivatives as selective and potent PI3Kδ inhibitors.
Drug Dev Res
; 84(8): 1709-1723, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37732677
6.
Identification of benzamides derivatives of norfloxacin as promising microRNA-21 inhibitors via repressing its transcription.
Bioorg Med Chem
; 66: 116803, 2022 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35561631
7.
Overcoming C797S mutation: The challenges and prospects of the fourth-generation EGFR-TKIs.
Bioorg Chem
; 128: 106057, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35964503
8.
Allyl phenyl selenides as H2O2 acceptors to develop ROS-responsive theranostic prodrugs.
Bioorg Chem
; 129: 106154, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36137311
9.
Irreversible epidermal growth factor receptor inhibitor Z25h exhibits pronounced inhibition on non-small cell lung adenocarcinoma cell line Hcc827.
Anticancer Drugs
; 32(4): 417-426, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33079732
10.
W941, a new PI3K inhibitor, exhibits preferable anti-proliferative activities against nonsmall cell lung cancer with autophagy inhibitors.
Invest New Drugs
; 38(5): 1218-1226, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31823159
11.
Research advances on selective phosphatidylinositol 3 kinase δ (PI3Kδ) inhibitors.
Bioorg Med Chem Lett
; 30(19): 127457, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32755681
12.
A novel small-molecule PI3K/Akt signaling inhibitor, W934, exhibits potent antitumor efficacy in A549 non-small-cell lung cancer.
Anticancer Drugs
; 30(9): 900-908, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30913062
13.
Synthesis of Aryl Trimethylstannane via BF3·OEt2-Mediated Cross-Coupling of Hexaalkyl Distannane Reagent with Aryl Triazene at Room Temperature.
J Org Chem
; 84(1): 463-471, 2019 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30540911
14.
Synthesis and biological evaluation of 4-(piperid-3-yl)amino substituted 6-pyridylquinazolines as potent PI3Kδ inhibitors.
Bioorg Med Chem
; 27(19): 115035, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31434616
15.
Alkylsulfonamide-containing quinazoline derivatives as potent and orally bioavailable PI3Ks inhibitors.
Bioorg Med Chem
; 27(20): 114930, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31176568
16.
The dual luciferase reporter system and RT-qPCR strategies for screening of MicroRNA-21 small-molecule inhibitors.
Biotechnol Appl Biochem
; 66(5): 755-762, 2019 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-31021480
17.
Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold.
Bioorg Med Chem
; 26(12): 3619-3633, 2018 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29853340
18.
Novel 6-aryl substituted 4-pyrrolidineaminoquinazoline derivatives as potent phosphoinositide 3-kinase delta (PI3Kδ) inhibitors.
Bioorg Med Chem
; 26(8): 2028-2040, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29534936
19.
Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors.
Bioorg Med Chem
; 26(8): 2173-2185, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29576272
20.
Introduction of pyrrolidineoxy or piperidineamino group at the 4-position of quinazoline leading to novel quinazoline-based phosphoinositide 3-kinase delta (PI3Kδ) inhibitors.
J Enzyme Inhib Med Chem
; 33(1): 651-656, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29536777