Detalhe da pesquisa
1.
Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses.
Nat Chem Biol
; 2024 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38355723
2.
Naphthylisoquinoline alkaloids, a new structural template inhibitor of Nav1.7 sodium channel.
Acta Pharmacol Sin
; 44(9): 1768-1776, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37142682
3.
Diversity-oriented synthesis of marine polybrominated diphenyl ethers as potential KCNQ potassium channel activators.
Bioorg Chem
; 126: 105909, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35661526
4.
SCN8A epileptic encephalopathy mutations display a gain-of-function phenotype and divergent sensitivity to antiepileptic drugs.
Acta Pharmacol Sin
; 43(12): 3139-3148, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35902765
5.
(-)-Naringenin 4',7-dimethyl Ether Isolated from Nardostachys jatamansi Relieves Pain through Inhibition of Multiple Channels.
Molecules
; 27(5)2022 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35268839
6.
CCT128930 is a novel and potent antagonist of TRPM7 channel.
Biochem Biophys Res Commun
; 560: 132-138, 2021 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33989904
7.
Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core.
Acta Pharmacol Sin
; 41(3): 293-302, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-31316182
8.
Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels.
Acta Pharmacol Sin
; 41(5): 629-637, 2020 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-31911638
9.
Inhibitory effects of lappaconitine on the neuronal isoforms of voltage-gated sodium channels.
Acta Pharmacol Sin
; 40(4): 451-459, 2019 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-29991710
10.
Enhancing inactivation rather than reducing activation of Nav1.7 channels by a clinically effective analgesic CNV1014802.
Acta Pharmacol Sin
; 39(4): 587-596, 2018 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-29094728
11.
The human ether-a-go-go-related gene activator NS1643 enhances epilepsy-associated KCNQ channels.
J Pharmacol Exp Ther
; 351(3): 596-604, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25232191
12.
A novel isoquinoline alkaloid HJ-69 isolated from Zanthoxylum bungeanum attenuates inflammatory pain by inhibiting voltage-gated sodium and potassium channels.
J Ethnopharmacol
; 330: 118218, 2024 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38677570
13.
Discovery of selective NaV1.8 inhibitors based on 5-chloro-2-(4,4-difluoroazepan-1-yl)-6-methyl nicotinamide scaffold for the treatment of pain.
Eur J Med Chem
; 254: 115371, 2023 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37084597
14.
Ligand activation mechanisms of human KCNQ2 channel.
Nat Commun
; 14(1): 6632, 2023 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37857637
15.
Identification of a Subtype-Selective Allosteric Inhibitor of GluN1/GluN3 NMDA Receptors.
Front Pharmacol
; 13: 888308, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35754487
16.
Spatial effects of carbon emission intensity and regional development in China.
Environ Sci Pollut Res Int
; 28(11): 14131-14143, 2021 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-33210249
17.
Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy.
J Med Chem
; 59(13): 6329-43, 2016 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27309376
18.
Activation of peripheral KCNQ channels relieves gout pain.
Pain
; 156(6): 1025-1035, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25735002
19.
[Determination of fatty acids in vegetable oils using comprehensive two-dimensional gas chromatography coupled to quadropole mass spectrometry].
Se Pu
; 30(11): 1166-71, 2012 Nov.
Artigo
em Zh
| MEDLINE | ID: mdl-23451520
20.
Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator which rescues LQTs mutants.
PLoS One
; 7(12): e51820, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23251633