Narrative review of ferroptosis in obesity.

Obesity is widely recognized as a major global health problem caused by a chronic energy imbalance resulting from a combination of excess caloric intake and insufficient energy expenditure. Excessive energy intake and physical inactivity are traditional risk factors for obesity. Obesity is a risk factor for many diseases, including hypertension, diabetes and tumours. Recent studies have found a strong link between ferroptosis and obesity. Ferroptosis is an iron-dependent regulated cell death caused by iron overload and reactive oxygen species-dependent excessive accumulation of lipid peroxidation. Ferroptosis is involved in many biological processes, such as amino acid metabolism, iron metabolism and lipid metabolism. Some potential strategies to reduce the adverse effects of ferroptosis on obesity are suggested and future research priorities are highlighted.

Bi-directional impulse chaos control in crystal growth.

Mono-silicon crystals, free of defects, are essential for the integrated circuit industry. Chaotic swing in the flexible shaft rotating-lifting (FSRL) system of the mono-silicon crystal puller causes harm to the quality of the crystal and must be suppressed in the crystal growth procedure. From the control system viewpoint, the constraints of the FSRL system can be summarized as not having measurable state variables for state feedback control, and only one parameter is available to be manipulated, namely, the rotation speed. From the application side, an additional constraint is that the control should affect the crystallization physical growth process as little as possible. These constraints make the chaos suppression in the FSRL system a challenging task. In this work, the analytical periodic solution of the swing in the FSRL system is derived using perturbation analysis. A bi-directional impulse control method is then proposed for suppressing chaos. This control method does not alter the average rotation speed. It is thus optimum regarding the crystallization process as compared with the single direction impulse control. The effectiveness and the robustness of the proposed chaos control method to parameter uncertainties are validated by the simulations.

Editorial: Lifespan Connectome Gradients for a Road to Mental Health.

The connectome, generally defined as a comprehensive map of the structural and/or functional connections of a complete set of neural elements, has been recognized to condense the mechanistic architecture of the brain and capture meaningful individual differences. Increasing efforts are being invested in exploring the associations between connectomes and behavior/symptoms to piece together guidelines from a systems/cognitive neuroscience perspective for reforming mental health care. This editorial sketches a road to mental health with lifespan connectome gradients (LCG), highlighting unique perspectives, prospects, and priorities.

Inhibition of glutathione metabolism can limit the development of pancreatic cancer.

Pharmacological inhibitors of glutathione synthesis and circulation, such as buthionine-sulfoximine, inhibit glutathione metabolism. These drugs decrease the aggressiveness of pancreatic cancer, inhibit tumor stem cell survival, and reduce chemotherapy resistance. Nevertheless, buthionine-sulfoximine also decreases the content of glutathione in normal cells, disrupts the balance between reactive oxygen species and glutathione, and eventually induces cell apoptosis. Pancreatic cancer is usually diagnosed at an advanced stage and has a poor prognosis. Consequently, the use of biomarkers to screen high-risk patients can be an effective method.

Pancreatic neuroendocrine tumors: A review of serum biomarkers, staging, and management.

Pancreatic neuroendocrine tumors (pNETs) are a heterogeneous group of tumors with complicated treatment options that depend on pathological grading, clinical staging, and presence of symptoms related to hormonal secretion. With regard to diagnosis, remarkable advances have been made: Chromogranin A is recommended as a general marker for pNETs. But other new biomarker modalities, like circulating tumor cells, multiple transcript analysis, microRNA profile, and cytokines, should be clarified in future investigations before clinical application. Therefore, the currently available serum biomarkers are insufficient for diagnosis, but reasonably acceptable in evaluating the prognosis of and response to treatments during follow-up of pNETs. Surgical resection is still the only curative therapeutic option for localized pNETs. However, a debulking operation has also been proven to be effective for controlling the disease. As for drug therapy, steroids and somatostatin analogues are the first-line therapy for those with positive expression of somatostatin receptor, while everolimus and sunitinib represent important progress for the treatment of patients with advanced pNETs. Great progress has been achieved in the combination of systematic therapy with local control treatments. The optimal timing of local control intervention, planning of sequential therapies, and implementation of multidisciplinary care remain pending.