Detalhe da pesquisa
1.
Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2.
Cell
; 181(3): 702-715.e20, 2020 04 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32315619
2.
Retraction Notice to: Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2.
Cell
; 185(16): 3058, 2022 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35931023
3.
Synthetic lethal targeting of TET2-mutant haematopoietic stem and progenitor cells by XPO1 inhibitors.
Br J Haematol
; 201(3): 489-501, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36746437
4.
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.
Nat Chem Biol
; 17(9): 954-963, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33972797
5.
LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors.
Proc Natl Acad Sci U S A
; 117(28): 16516-16526, 2020 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32601179
6.
Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies.
PLoS Genet
; 15(4): e1008039, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30970016
7.
Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility.
J Biol Chem
; 289(9): 5904-13, 2014 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24403062
8.
STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma.
Cell Rep Med
; 5(3): 101472, 2024 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38508140
9.
Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.
J Clin Invest
; 134(8)2024 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38618957
10.
Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State.
bioRxiv
; 2023 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36909587
11.
Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state.
J Clin Invest
; 133(10)2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37183825
12.
Intrinsic transcriptional heterogeneity in neuroblastoma guides mechanistic and therapeutic insights.
Cell Rep Med
; 3(5): 100632, 2022 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35584622
13.
p53 Pathway Inactivation Drives SMARCB1-deficient p53-wildtype Epithelioid Sarcoma Onset Indicating Therapeutic Vulnerability Through MDM2 Inhibition.
Mol Cancer Ther
; 21(11): 1689-1700, 2022 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36099437
14.
EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma.
Cancer Discov
; 12(3): 730-751, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34772733
15.
Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma.
Sci Adv
; 7(43): eabe0834, 2021 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34669465
16.
Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss.
Oncogene
; 40(38): 5718-5729, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34331013
17.
MEIS2 Is an Adrenergic Core Regulatory Transcription Factor Involved in Early Initiation of TH-MYCN-Driven Neuroblastoma Formation.
Cancers (Basel)
; 13(19)2021 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34638267
18.
Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
Nat Commun
; 12(1): 5577, 2021 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34552066
19.
ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression.
Sci Adv
; 6(29): eaaz3440, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32832616
20.
suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types.
Dis Model Mech
; 13(8)2020 08 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32651197