Detalhe da pesquisa
1.
Longitudinal metabolite profiling of Streptococcus pneumoniae-associated community-acquired pneumonia.
Metabolomics
; 20(2): 35, 2024 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38441696
2.
Model-based dose optimization framework for bedaquiline, pretomanid and linezolid for the treatment of drug-resistant tuberculosis.
Br J Clin Pharmacol
; 90(2): 463-474, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37817504
3.
Generation of realistic virtual adult populations using a model-based copula approach.
J Pharmacokinet Pharmacodyn
; 2024 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38844624
4.
Protein structure-based gene expression signatures.
Proc Natl Acad Sci U S A
; 118(19)2021 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33941686
5.
Semi-mechanistic modeling of resistance development to ß-lactam and ß-lactamase-inhibitor combinations.
J Pharmacokinet Pharmacodyn
; 2023 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38008877
6.
Systems Pharmacology: Defining the Interactions of Drug Combinations.
Annu Rev Pharmacol Toxicol
; 59: 21-40, 2019 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30260737
7.
Quantitative Systems Pharmacology Modeling Framework of Autophagy in Tuberculosis: Application to Adjunctive Metformin Host-Directed Therapy.
Antimicrob Agents Chemother
; 66(8): e0036622, 2022 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35862740
8.
Characterizing the kinetics of presepsin and associated inflammatory biomarkers in human endotoxemia.
Inflamm Res
; 71(9): 999-1001, 2022 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-35861876
9.
Host-response biomarkers for the diagnosis of bacterial respiratory tract infections.
Clin Chem Lab Med
; 57(4): 442-451, 2019 03 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30183665
10.
Pharmacodynamic modeling of cardiac biomarkers in breast cancer patients treated with anthracycline and trastuzumab regimens.
J Pharmacokinet Pharmacodyn
; 45(3): 431-442, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29429038
11.
Evaluating renal function and age as predictors of amikacin clearance in neonates: model-based analysis and optimal dosing strategies.
Br J Clin Pharmacol
; 82(3): 793-805, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27198625
12.
Pooled population pharmacokinetic model of imipenem in plasma and the lung epithelial lining fluid.
Br J Clin Pharmacol
; 81(6): 1113-23, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26852277
13.
Pronounced between-subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers.
Br J Clin Pharmacol
; 82(3): 706-16, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27161955
14.
Structure-Based Prediction of Anti-infective Drug Concentrations in the Human Lung Epithelial Lining Fluid.
Pharm Res
; 33(4): 856-67, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26626793
15.
Integrated semi-physiological pharmacokinetic model for both sunitinib and its active metabolite SU12662.
Br J Clin Pharmacol
; 79(5): 809-19, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25393890
16.
Towards integrative systems pharmacology models in oncology drug development.
Drug Discov Today Technol
; 15: 1-8, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26464083
17.
Design of informative renal impairment studies: evaluation of the impact of design stratification on bias, precision and dose adjustment error.
Invest New Drugs
; 32(5): 913-27, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24788562
18.
Design of a drug-drug interaction study of vincristine with azole antifungals in pediatric cancer patients using clinical trial simulation.
Pediatr Blood Cancer
; 61(12): 2223-9, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25175364
19.
Non-linear blood-brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix.
Br J Pharmacol
; 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38663441
20.
Predictions of Bedaquiline Central Nervous System Exposure in Patients with Tuberculosis Meningitis Using Physiologically based Pharmacokinetic Modeling.
Clin Pharmacokinet
; 63(5): 657-668, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38530588