Detalhe da pesquisa
1.
Current Mechanistic and Pharmacodynamic Understanding of Melanocortin-4 Receptor Activation.
Molecules
; 24(10)2019 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31100979
2.
Differentiation of antiinflammatory and antitumorigenic properties of stabilized enantiomers of thalidomide analogs.
Proc Natl Acad Sci U S A
; 112(12): E1471-9, 2015 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25775521
3.
Double blind trial of a deuterated form of linoleic acid (RT001) in Friedreich ataxia.
J Neurol
; 270(3): 1615-1623, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-36462055
4.
Deuterium-Stabilized (R)-Pioglitazone (PXL065) Is Responsible for Pioglitazone Efficacy in NASH yet Exhibits Little to No PPARγ Activity.
Hepatol Commun
; 5(8): 1412-1425, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34430785
5.
The melanocortin pathway and energy homeostasis: From discovery to obesity therapy.
Mol Metab
; 48: 101206, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33684608
6.
Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant.
Bioorg Med Chem Lett
; 20(16): 4757-61, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20643546
7.
Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands.
Bioorg Med Chem Lett
; 20(15): 4483-6, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20598533
8.
Plasma and Red Blood Cell Membrane Accretion and Pharmacokinetics of RT001 (bis-Allylic 11,11-D2-Linoleic Acid Ethyl Ester) during Long Term Dosing in Patients.
J Pharm Sci
; 109(11): 3496-3503, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32871154
9.
ANERGY TO SYNERGY-THE ENERGY FUELING THE RXCOVEA FRAMEWORK.
Int J Multiscale Comput Eng
; 18(3): 329-333, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32831809
10.
Tracing the effect of the melanocortin-4 receptor pathway in obesity: study design and methodology of the TEMPO registry.
Appl Clin Genet
; 12: 87-93, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31239751
11.
Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators.
Bioorg Med Chem Lett
; 18(11): 3242-7, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18479920
12.
Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment.
J Clin Endocrinol Metab
; 103(7): 2601-2612, 2018 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29726959
13.
MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency.
Nat Med
; 24(5): 551-555, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29736023
14.
Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice.
Mol Cell Biol
; 22(14): 5027-35, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12077332
15.
Deuterium-reinforced polyunsaturated fatty acids protect against atherosclerosis by lowering lipid peroxidation and hypercholesterolemia.
Atherosclerosis
; 264: 100-107, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28655430
16.
Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency.
Mol Metab
; 6(10): 1321-1329, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29031731
17.
Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity.
J Med Chem
; 49(26): 7584-7, 2006 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17181138
18.
Design and synthesis of (ant)-agonists that alter appetite and adiposity.
Prog Brain Res
; 153: 107-18, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16876570
19.
Magel2-null mice are hyper-responsive to setmelanotide, a melanocortin 4 receptor agonist.
Br J Pharmacol
; 173(17): 2614-21, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27339818
20.
Alpha-melanocyte-stimulating hormone stimulates oxytocin release from the dendrites of hypothalamic neurons while inhibiting oxytocin release from their terminals in the neurohypophysis.
J Neurosci
; 23(32): 10351-8, 2003 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-14614094