Taurine-Carbohydrate Derivative Stimulates Fibrillogenesis of Amyloid-ß and Reduce Alzheimer-Like Behaviors.

Amyloid-ß (Aß) aggregates are a hallmark of Alzheimer's disease (AD). Through the misfolding process of Aß in the brain, oligomeric forms of Aß accumulate and significantly damage the brain cells inducing neuronal loss and cognitive dysfunctions that lead to AD. We hypothesized that decrease in Aß oligomers during the aggregation process might be able to reduce Aß-dependent brain damage. As taurine-like chemicals are often reported to have direct binding abilities to Aß, we prepared a chemical library that consisted of taurine-carbohydrate derivatives to search for molecules that target Aß and accelerate its fibrillogenesis. Here, we report that 1-deoxy-1-(2-sulfoethylamino)-D-fructose stimulates the formation of relatively less toxic Aß fibrils leading to prevention of cognitive deficits in AD acute model mice.