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1.
J Transl Med ; 22(1): 609, 2024 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-38956586

RESUMO

Sustained injury from factors such as hypoxia, infection, or physical damage may provoke improper tissue repair and the anomalous deposition of connective tissue that causes fibrosis. This phenomenon may take place in any organ, ultimately leading to their dysfunction and eventual failure. Tissue fibrosis has also been found to be central in both the process of carcinogenesis and cancer progression. Thus, its prompt diagnosis and regular monitoring is necessary for implementing effective disease-modifying interventions aiming to reduce mortality and improve overall quality of life. While significant research has been conducted on these subjects, a comprehensive understanding of how their relationship manifests through modern imaging techniques remains to be established. This work intends to provide a comprehensive overview of imaging technologies relevant to the detection of fibrosis affecting thoracic organs as well as to explore potential future advancements in this field.


Assuntos
Fibrose , Humanos , Tórax/diagnóstico por imagem , Tórax/patologia
2.
J Transl Med ; 22(1): 616, 2024 Jul 03.
Artigo em Inglês | MEDLINE | ID: mdl-38961396

RESUMO

Fibrosis is a pathological process involving the abnormal deposition of connective tissue, resulting from improper tissue repair in response to sustained injury caused by hypoxia, infection, or physical damage. It can impact any organ, leading to their dysfunction and eventual failure. Additionally, tissue fibrosis plays an important role in carcinogenesis and the progression of cancer.Early and accurate diagnosis of organ fibrosis, coupled with regular surveillance, is essential for timely disease-modifying interventions, ultimately reducing mortality and enhancing quality of life. While extensive research has already been carried out on the topics of aberrant wound healing and fibrogenesis, we lack a thorough understanding of how their relationship reveals itself through modern imaging techniques.This paper focuses on fibrosis of the genito-urinary system, detailing relevant imaging technologies used for its detection and exploring future directions.


Assuntos
Fibrose , Humanos , Sistema Urogenital/diagnóstico por imagem , Sistema Urogenital/patologia , Radiologia
3.
Curr Gene Ther ; 24(3): 217-238, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38310458

RESUMO

BACKGROUND: Segmentation of medical images plays a key role in the correct identification and management of different diseases. In this study, we present a new segmentation method that meets the difficulties posed by sophisticated organ shapes in computed tomography (CT) images, particularly targeting lung, breast, and gastric cancers. METHODS: Our suggested methods, Resio-Inception U-Net and Deep Cluster Recognition (RIUDCR), use a Residual Inception Architecture, which combines the power of residual connections and inception blocks to achieve cutting-edge segmentation performance while reducing the risk of overfitting. RESULTS: We present mathematical equations and functions that describe the design, including the encoding and decoding steps within the UC-Net system. Furthermore, we provide strong testing results that show the effectiveness of our method. Through thorough testing on varied datasets, our method regularly beats current techniques, achieving amazing precision and stability in organ task segmentation. These results show the promise of our residual inception architecture in better medical picture analysis. CONCLUSION: In summary, our research not only shows a state-of-the-art segment methodology but also reinforces its usefulness through thorough testing. The inclusion of residual inception architecture in medical picture segmentation offers good possibilities for improving the identification and management of disease planning.


Assuntos
Tomografia Computadorizada por Raios X , Humanos , Tomografia Computadorizada por Raios X/métodos , Processamento de Imagem Assistida por Computador/métodos , Algoritmos , Redes Neurais de Computação , Tórax/diagnóstico por imagem , Pulmão/diagnóstico por imagem , Análise por Conglomerados , Feminino , Aprendizado Profundo
4.
World J Transplant ; 12(5): 83-87, 2022 May 18.
Artigo em Inglês | MEDLINE | ID: mdl-35663542

RESUMO

This editorial describes the indications and technical aspects of the simultaneous retrieval of thoracic and abdominal organs in Maastricht III donors as well as the preservation of such organs until their implantation.

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