Asynchronous behavioral and neurophysiological changes in word production in the adult lifespan.

Behavioral and brain-related changes in word production have been claimed to predominantly occur after 70 years of age. Most studies investigating age-related changes in adulthood only compared young to older adults, failing to determine whether neural processes underlying word production change at an earlier age than observed in behavior. This study aims to fill this gap by investigating whether changes in neurophysiological processes underlying word production are aligned with behavioral changes. Behavior and the electrophysiological event-related potential patterns of word production were assessed during a picture naming task in 95 participants across five adult lifespan age groups (ranging from 16 to 80 years old). While behavioral performance decreased starting from 70 years of age, significant neurophysiological changes were present at the age of 40 years old, in a time window (between 150 and 220 ms) likely associated with lexical-semantic processes underlying referential word production. These results show that neurophysiological modifications precede the behavioral changes in language production; they can be interpreted in line with the suggestion that the lexical-semantic reorganization in mid-adulthood influences the maintenance of language skills longer than for other cognitive functions.

Early language dissociation in bilingual minds: magnetoencephalography evidence through a machine learning approach.

Does neural activity reveal how balanced bilinguals choose languages? Despite using diverse neuroimaging techniques, prior studies haven't provided a definitive solution to this problem. Nonetheless, studies involving direct brain stimulation in bilinguals have identified distinct brain regions associated with language production in different languages. In this magnetoencephalography study with 45 proficient Spanish-Basque bilinguals, we investigated language selection during covert picture naming and word reading tasks. Participants were prompted to name line drawings or read words if the color of the stimulus changed to green, in 10% of trials. The task was performed either in Spanish or Basque. Despite similar sensor-level evoked activity for both languages in both tasks, decoding analyses revealed language-specific classification ~100 ms post-stimulus onset. During picture naming, right occipital-temporal sensors predominantly contributed to language decoding, while left occipital-temporal sensors were crucial for decoding during word reading. Cross-task decoding analysis unveiled robust generalization effects from picture naming to word reading. Our methodology involved a fine-grained examination of neural responses using magnetoencephalography, offering insights into the dynamics of language processing in bilinguals. This study refines our understanding of the neural underpinnings of language selection and bridges the gap between non-invasive and invasive experimental evidence in bilingual language production.

Neural Correlates of Semantic Interference and Phonological Facilitation in Picture Naming: A Systematic Review and Coordinate-Based Meta-analysis.

Semantic interference (SI) and phonological facilitation (PF) effects occur when multiple representations are co-activated simultaneously in complex naming paradigms, manipulating the context in which word production is set. Although the behavioral consequences of these psycholinguistic effects are well-known, the involved brain structures are still controversial. This paper aims to provide a systematic review and a coordinate-based meta-analysis of the available functional neuroimaging studies investigating SI and PF in picture naming paradigms. The included studies were fMRI experiments on healthy subjects, employing paradigms in which co-activations of representations were obtained by manipulating the naming context using semantically or phonologically related items. We examined the principal methodological aspects of the included studies, emphasizing the existing commonalities and discrepancies across single investigations. We then performed an exploratory coordinate-based meta-analysis of the reported activation peaks of neural response related to SI and PF. Our results consolidated previous findings regarding the involvement of the left inferior frontal gyrus and the left middle temporal gyrus in SI and brought out the role of bilateral inferior parietal regions in PF.

Why is a flamingo named as pelican and asparagus as celery? Understanding the relationship between targets and errors in a speeded picture naming task.

Speakers sometimes make word production errors, such as mistakenly saying pelican instead of flamingo. This study explored which properties of an error influence the likelihood of its selection over the target word. Analysing real-word errors in speeded picture naming, we investigated whether, relative to the target, naming errors were more typical representatives of the semantic category, were associated with more semantic features, and/or were semantically more closely related to the target than its near semantic neighbours were on average. Results indicated that naming errors tended to be more typical category representatives and possess more semantic features than the targets. Moreover, while not being the closest semantic neighbours, errors were largely near semantic neighbours of the targets. These findings suggest that typicality, number of semantic features, and semantic similarity govern activation levels in the production system, and we discuss possible mechanisms underlying these effects in the context of word production theories.

The dynamics of cortical interactions in visual recognition of object category: living versus nonliving.

Noninvasive brain imaging studies have shown that higher visual processing of objects occurs in neural populations that are separable along broad semantic categories, particularly living versus nonliving objects. However, because of their limited temporal resolution, these studies have not been able to determine whether broad semantic categories are also reflected in the dynamics of neural interactions within cortical networks. We investigated the time course of neural propagation among cortical areas activated during object naming in 12 patients implanted with subdural electrode grids prior to epilepsy surgery, with a special focus on the visual recognition phase of the task. Analysis of event-related causality revealed significantly stronger neural propagation among sites within ventral temporal lobe (VTL) at early latencies, around 250 ms, for living objects compared to nonliving objects. Differences in other features, including familiarity, visual complexity, and age of acquisition, did not significantly change the patterns of neural propagation. Our findings suggest that the visual processing of living objects relies on stronger causal interactions among sites within VTL, perhaps reflecting greater integration of visual feature processing. In turn, this may help explain the fragility of naming living objects in neurological diseases affecting VTL.

Lexical retrieval difficulties in post-COVID-19 syndrome: Insights from verbal fluency and naming tasks.

BACKGROUND: Although considerable research has been conducted on post-COVID-19 syndrome (PCS), cognitive symptoms, particularly those related to language, are still not well understood. AIMS: To provide a detailed quantitative and qualitative analysis of language performance in PCS patients using a comprehensive set of semantic and verbal production tasks. METHODS & PROCEDURES: The study involved 195 PCS patients aged 26-64 years and 50 healthy controls aged 25-61 years. Participants were assessed using two semantic tasks, three naming tasks and four types of verbal fluency tasks, designed to evaluate different aspects of language processing. OUTCOMES & RESULTS: PCS patients demonstrated significantly poorer performance compared with controls across all verbal fluency tasks. This was evident in both the total number of words generated and their types, with patients tending to choose more easily accessible words. In naming tasks, the pattern of errors was similar in both groups, although patients showed a higher number of non-responses and made more errors, reflecting difficulties in word retrieval. The analysis highlighted the impact of factors such as stimulus availability, educational level and cognitive reserve on performance. Notably, younger patients performed worse than older, a paradoxical trend also observed in previous research. CONCLUSIONS & IMPLICATIONS: These findings reveal significant word retrieval difficulties in PCS patients, suggesting that cognitive impairment related to language may be more pronounced than previously understood. The results underscore the need for a thorough evaluation of language functions in PCS patients and the development of more targeted and individualized language rehabilitation strategies to address these specific challenges. WHAT THIS PAPER ADDS: What is already known on the subject Studies on the cognitive characteristics of CPS have focused mainly on broad-spectrum neuropsychological assessments covering all cognitive functions. However, there are very few studies analysing oral production with specific lexical and semantic system tasks. Furthermore, no work has specifically included tasks assessing semantic processing or conducted qualitative analyses of the psycholinguistic variables affecting performance. Such analyses could undoubtedly help clarify the nature of the language impairments in patients with PCS. What this paper adds to the existing knowledge This study explores in depth the evaluation and analysis of the oral production of patients with PCS using several lexical and semantic tasks. In addition, psycholinguistic variables are analysed that could undoubtedly help clarify the nature of the language impairments in patients with PCS. What are the potential or actual clinical implications of this work? The study allows the identification of specific lexical-semantic deficits in the spoken language in patients with this PCS. A more detailed assessment of the oral language of these patients, keeping in mind the psycholinguistic variables that may affect the performance, will facilitate the design of more efficient and individualized rehabilitation programmes.

The MINT Sprint 2.0: A picture naming test for detection of naming impairments in Alzheimer's disease and in preclinical AD.

INTRODUCTION: Evidence on the onset of naming deficits in Alzheimer's disease (AD) is mixed. Some studies showed an early decline, but others did not. The present study introduces evidence from a novel naming test. METHODS: Cognitively normal (n = 138), mild cognitive impairment (MCI; n = 21), and Alzheimer's disease (AD; n = 31) groups completed an expanded Multilingual Naming Test with a time-pressured administration procedure (MINT Sprint 2.0). Cerebrospinal fluid biomarkers classified participants as true controls (n = 61) or preclinical AD (n = 26). RESULTS: Total correct MINT Sprint 2.0 scores exhibited good sensitivity and specificity (>0.85) for discriminating true controls from cognitively impaired (MCI/AD) groups and showed significant differences between true controls and preclinical AD groups. Time measurement did not improve classification, but percent resolved scores exhibited promise as an independent AD marker. DISCUSSION: Naming deficits can be detected in the earliest stages of AD with tests and procedures designed for this purpose.

Timed picture naming norms for 800 photographs of 200 objects in English.

The present study presents picture-naming norms for a large set of 800 high-quality photographs of 200 natural objects and artefacts spanning a range of categories, with four unique images per object. Participants were asked to provide a single, most appropriate name for each image seen. We report recognition latencies for each image, and several normed variables for the provided names: agreement, H-statistic (i.e. level of naming uncertainty), Zipf word frequency and word length. Rather than simply focusing on a single name per image (i.e. the modal or most common name), analysis of recognition latencies showed that it is important to consider the diversity of labels that participants may ascribe to each pictured object. The norms therefore provide a list of candidate labels per image with weighted measures of word length and frequency per image that incorporate all provided names, as well as modal measures based on the most common name only.

Phonological neighbourhood effects in Italian speech production: Evidence from healthy and neurologically impaired populations.

In two speech production studies conducted in Italian, we investigated the impact of phonological neighbourhood properties such as the neighbourhood density and the mean frequency of the neighbours on speech processing. Two populations of healthy (Study 1) and neurologically impaired (Study 2) individuals were tested. We employed multi-regression methods to analyse naming latencies in Study 1 and accuracy rates in Study 2 while controlling for various psycholinguistic predictors. In Study 1, pictures with words from high-density neighbourhoods were named faster than those from low-density neighbourhoods. Additionally, words with high-frequency neighbours were named faster in Study 1 and yielded higher accuracy rates in Study 2. The results suggest facilitatory effects of both the phonological neighbourhood density and frequency neighbourhood variables. Furthermore, we observed interactions between these two phonological neighbourhood variables and name agreement and repetition. Specifically, the facilitation effect was more pronounced for pictures with lower name agreement and during the initial presentation of the pictures. These findings are discussed in the context of previous literature and within the framework of interactive models of speech production.

Deficits in naming pictures of objects are associated with glioma infiltration of the inferior longitudinal fasciculus: A study with diffusion MRI tractography, volumetric MRI, and neuropsychology.

It has been suggested that the inferior longitudinal fasciculus (ILF) may play an important role in several aspects of language processing such as visual object recognition, visual memory, lexical retrieval, reading, and specifically, in naming visual stimuli. In particular, the ILF appears to convey visual information from the occipital lobe to the anterior temporal lobe (ATL). However, direct evidence proving the essential role of the ILF in language and semantics remains limited and controversial. The first aim of this study was to prove that patients with a brain glioma damaging the left ILF would be selectively impaired in picture naming of objects; the second aim was to prove that patients with glioma infiltrating the ATL would not be impaired due to functional reorganization of the lexical retrieval network elicited by the tumor. We evaluated 48 right-handed patients with neuropsychological testing and magnetic resonance imaging (MRI) before and after surgery for resection of a glioma infiltrating aspects of the left temporal, occipital, and/or parietal lobes; diffusion tensor imaging (DTI) was acquired preoperatively in all patients. Damage to the ILF, inferior frontal occipital fasciculus (IFOF), uncinate fasciculus (UF), arcuate fasciculus (AF), and associated cortical regions was assessed by means of preoperative tractography and pre-/pos-toperative MRI volumetry. The association of fascicles damage with patients' performance in picture naming and three additional cognitive tasks, namely, verbal fluency (two verbal non-visual tasks) and the Trail Making Test (a visual attentional task), was evaluated. Nine patients were impaired in the naming test before surgery. ILF damage was demonstrated with tractography in six (67%) of these patients. The odds of having an ILF damage was 6.35 (95% CI: 1.27-34.92) times higher among patients with naming deficit than among those without it. The ILF was the only fascicle to be significantly associated with naming deficit when all the fascicles were considered together, achieving an adjusted odds ratio of 15.73 (95% CI: 2.30-178.16, p = .010). Tumor infiltration of temporal and occipital cortices did not contribute to increase the odd of having a naming deficit. ILF damage was found to be selectively associated with picture naming deficit and not with lexical retrieval assessed by means of verbal fluency. Early after surgery, 29 patients were impaired in naming objects. The association of naming deficit with percentage of ILF resection (assessed by 3D-MRI) was confirmed (beta = -56.78 ± 20.34, p = .008) through a robust multiple linear regression model; no significant association was found with damage of IFOF, UF or AF. Crucially, postoperative neuropsychological evaluation showed that naming scores of patients with tumor infiltration of the anterior temporal cortex were not significantly associated with the percentage of ILF damage (rho = .180, p > .999), while such association was significant in patients without ATL infiltration (rho = -.556, p = .004). The ILF is selectively involved in picture naming of objects; however, the naming deficits are less severe in patients with glioma infiltration of the ATL probably due to release of an alternative route that may involve the posterior segment of the AF. The left ILF, connecting the extrastriatal visual cortex to the anterior region of the temporal lobe, is crucial for lexical retrieval on visual stimulus, such as in picture naming. However, when the ATL is also damaged, an alternative route is released and the performance improves.

Asynchronous, online spaced-repetition training alleviates word-finding difficulties in aphasia.

Word-finding difficulties for naming everyday objects are often prevalent in aphasia. Traditionally, treating these difficulties has involved repeated drilling of troublesome items with a therapist. Spaced repetition schedules can improve the efficiency of such training. However, spaced repetition in a therapy environment can be both difficult to implement and time-consuming. The current study evaluated the potential utility of automated, asynchronous, online spaced repetition training for the treatment of word-finding difficulties in individuals with aphasia. Twenty-one participants completed a two-week training study, completing approximately 60 minutes per day of asynchronous online drilling. The training items were identified using a pretest, and word-finding difficulties were evaluated both at the end of training (i.e., a post-test) and four weeks later (i.e., a retention test). The trained items were separated into three different spaced-repetition schedules: (1) Short-spacing; (2) Long-spacing; and (3) Adaptive-spacing. At the retention-test, all trained items outperformed non-trained items in terms of accuracy and reaction time. Further, preliminary evidence suggested a potential reaction time advantage for the adaptive-spacing condition. Overall, online, asynchronous spaced repetition training appears to be effective in treating word-finding difficulties in aphasia. Further research will be required to determine if different spaced repetition schedules can be leveraged to enhance this effect.

Web-based language production experiments: Semantic interference assessment is robust for spoken and typed response modalities.

For experimental research on language production, temporal precision and high quality of the recorded audio files are imperative. These requirements are a considerable challenge if language production is to be investigated online. However, online research has huge potential in terms of efficiency, ecological validity and diversity of study populations in psycholinguistic and related research, also beyond the current situation. Here, we supply confirmatory evidence that language production can be investigated online and that reaction time (RT) distributions and error rates are similar in written naming responses (using the keyboard) and typical overt spoken responses. To assess semantic interference effects in both modalities, we performed two pre-registered experiments (n = 30 each) in online settings using the participants' web browsers. A cumulative semantic interference (CSI) paradigm was employed that required naming several exemplars of semantic categories within a seemingly unrelated sequence of objects. RT is expected to increase linearly for each additional exemplar of a category. In Experiment 1, CSI effects in naming times described in lab-based studies were replicated. In Experiment 2, the responses were typed on participants' computer keyboards, and the first correct key press was used for RT analysis. This novel response assessment yielded a qualitatively similar, very robust CSI effect. Besides technical ease of application, collecting typewritten responses and automatic data preprocessing substantially reduce the work load for language production research. Results of both experiments open new perspectives for research on RT effects in language experiments across a wide range of contexts. JavaScript- and R-based implementations for data collection and processing are available for download.

Polish norms for a set of colored drawings of 168 objects and 146 actions with predictors of naming performance.

In this study, we present the first database of pictures and their corresponding psycholinguistic norms for Polish: the CLT database. In this norming study, we used the pictures from Cross-Linguistic Lexical Tasks (CLT): a set of colored drawings of 168 object and 146 actions. The CLT pictures were carefully created to provide a valid tool for multicultural comparisons. The pictures are accompanied by norms for Naming latencies, Name agreement, Goodness of depiction, Image agreement, Concept familiarity, Age of acquisition, Imageability, Lexical frequency, and Word complexity. We also report analyses of predictors of Naming latencies for pictures of objects and actions. Our results show that Name agreement, Concept familiarity, and Lexical frequency are significant predictors of Naming latencies for pictures of both objects and actions. Additionally, Age of acquisition significantly predicts Naming latencies of pictures of objects. The CLT database is freely available at osf.io/gp9qd. The full set of CLT pictures, including additional variants of pictures, is available on request at osf.io/y2cwr.

Investigating the influence of semantic factors on word retrieval: Reservations, results and recommendations.

There is consensus that word retrieval starts with activation of semantic representations. However, in adults without language impairment, relatively little attention has been paid to the effects of the semantic attributes of to-be-retrieved words. This paper, therefore, addresses the question of which item-inherent semantic factors influence word retrieval. Specifically, it reviews the literature on a selection of these factors: imageability, concreteness, number of semantic features, typicality, intercorrelational density, featural distinctiveness, concept distinctiveness, animacy, semantic neighbourhood density, semantic similarity, operativity, valence, and arousal. It highlights several methodological challenges in this field, and has a focus on the insights from studies with people with aphasia where the effects of these variables are more prevalent. The paper concludes that further research simultaneously examining the effects of different semantic factors that are likely to affect lexical co-activation, and the interaction of these variables, would be fruitful, as would suitably scaled computational modelling of these effects in unimpaired language processing and in language impairment. Such research would enable the refinement of theories of semantic processing and word production, and potentially have implications for diagnosis and treatment of semantic and lexical impairments.

Picture-naming test for a linguistically diverse population with cognitive impairment and dementia.

BACKGROUND: Picture-naming tests (PNTs) evaluate linguistic impairment in dementia due to semantic memory impairment, impaired lexical retrieval or perceptual deficits. They also assess the decline in naming impairment at various stages of dementia and mild cognitive impairment (MCI) that occurs due to progressive cognitive impairment. With the increasing numbers of people with dementia globally, it is necessary to have validated naming tests and norms that are culturally and linguistically appropriate. AIMS: In this cross-sectional study we harmonized a set of 30 images applicable to the Indian context across five languages and investigated the picture-naming performance in patients with MCI and dementia. METHODS & PROCEDURES: A multidisciplinary expert group formed by the Indian Council of Medical Research (ICMR) collaborated towards developing and adapting a picture naming test (PNT) known as the ICMR-PNT in five Indian languages: Hindi, Bengali, Telugu, Kannada and Malayalam. Based on cross-cultural adaptation guidelines and item-wise factor analysis and correlations established separately across five languages, the final version of the ICMR-PNT test was developed. A total of 368 controls, 123 dementia and 128 MCI patients were recruited for the study. Psychometric properties of the adapted version of the ICMR-PNT were examined, and sensitivity and specificity were examined. OUTCOMES & RESULTS: The ICMR-PNT scores in all languages combined were higher in controls compared with patients with dementia and MCI (F2, 615 = 139.85; p < 0.001). Furthermore, PNT scores for MCI was higher in comparison with patients with dementia in all languages combined (p < 0.001). The area under the curve across the five languages ranged from 0.81 to 1.00 for detecting dementia. There was a negative correlation between Clinical Dementia Rating (CDR) and ICMR-PNT scores and a positive correlation between Addenbrooke's Cognitive Examination-III (ACE-III) and ICMR-PNT scores in control and patient groups. CONCLUSIONS & IMPLICATIONS: The ICMR-PNT was developed by following cross-cultural adaptation guidelines and establishing correlations using item-wise factor analysis across five languages. This adapted PNT was found to be a reliable tool when assessing naming abilities effectively in mild to moderate dementia in a linguistically diverse context. WHAT THIS PAPER ADDS: What is already known on this subject Picture-naming evaluates language impairment linked to naming difficulties due to semantic memory, lexical retrieval or perceptual disturbances. As a result, picture naming tests (PNTs) play an important role in the diagnosis of dementia. In a heterogeneous population such as India, there is a need for a common PNT that can be used across the wide range of languages. What this study adds to existing knowledge PNTs such as the Boston Naming Test (BNT) were developed for the educated, mostly English-speaking, Western populations and are not appropriate for use in an Indian context. To overcome this challenge, a PNT was harmonized in five Indian languages (Hindi, Bengali, Telugu, Kannada and Malayalam) and we report the patterns of naming difficulty in patients with MCI and dementia. The ICMR-PNT demonstrated good diagnostic accuracy when distinguishing patients with mild to moderate dementia from cognitively normal individuals. What are the potential or actual clinical implications of this work? With the growing number of persons suffering from Alzheimer's disease and other forms of dementia around the world, its critical to have culturally and linguistically relevant naming tests and diagnosis. This validated ICMR-PNT can be used widely as a clinical tool to diagnose dementia and harmonize research efforts across diverse populations.

The effects of multiple linguistic variables on picture naming in American Sign Language.

Picture-naming tasks provide critical data for theories of lexical representation and retrieval and have been performed successfully in sign languages. However, the specific influences of lexical or phonological factors and stimulus properties on sign retrieval are poorly understood. To examine lexical retrieval in American Sign Language (ASL), we conducted a timed picture-naming study using 524 pictures (272 objects and 251 actions). We also compared ASL naming with previous data for spoken English for a subset of 425 pictures. Deaf ASL signers named object pictures faster and more consistently than action pictures, as previously reported for English speakers. Lexical frequency, iconicity, better name agreement, and lower phonological complexity each facilitated naming reaction times (RT)s. RTs were also faster for pictures named with shorter signs (measured by average response duration). Target name agreement was higher for pictures with more iconic and shorter ASL names. The visual complexity of pictures slowed RTs and decreased target name agreement. RTs and target name agreement were correlated for ASL and English, but agreement was lower for ASL, possibly due to the English bias of the pictures. RTs were faster for ASL, which we attributed to a smaller lexicon. Overall, the results suggest that models of lexical retrieval developed for spoken languages can be adopted for signed languages, with the exception that iconicity should be included as a factor. The open-source picture-naming data set for ASL serves as an important, first-of-its-kind resource for researchers, educators, or clinicians for a variety of research, instructional, or assessment purposes.

German normative data with naming latencies for 283 action pictures and 600 action verbs.

Timed picture naming is a common psycholinguistic paradigm. In this task, participants are asked to label visually depicted objects or actions. Naming performance can be influenced by several picture and verb characteristics which demands fully characterized normative data. In this study, we provide a first German normative data set of picture and verb characteristics associated with a compilation of 283 freely available action pictures and 600 action verbs including naming latencies from 55 participants. We report standard measures for pictures and verbs such as name agreement indices, visual complexity, word frequency, word length, imageability and age of acquisition. In addition, we include less common parameters, such as orthographic Levenshtein distance, transitivity, reflexivity, morphological complexity, and motor content of the pictures and their associated verbs. We use repeated measures correlations in order to investigate associations between picture and word characteristics and linear mixed effects modeling for the prediction of naming latency. Our analyses reveal comparable results to previous studies in other languages, indicating high construct validity. We found that naming latency varied as a function of entropy of responses, word frequency and motor content of pictures and words. In summary, we provide first German normative data for action pictures and their associated verbs and identify variables influencing naming latency.

LinguaPix database: A megastudy of picture-naming norms.

The major aim of the present megastudy of picture-naming norms was to address the shortcomings of the available picture data sets used in psychological and linguistic research by creating a new database of normed colour images that researchers from around the world can rely upon in their investigations. In order to do this, we employed a new form of normative study, namely a megastudy, whereby 1620 colour photographs of items spanning across 42 semantic categories were named and rated by a group of German speakers. This was done to establish the following linguistic norms: speech onset times (SOT), name agreement, accuracy, familiarity, visual complexity, valence, and arousal. The data, including over 64,000 audio files, were used to create the LinguaPix database of pictures, audio recordings, and linguistic norms, which to our knowledge, is the largest available research tool of its kind ( http://linguapix.uni-mannheim.de ). In this paper, we present the tool and the analysis of the major variables.

Picture naming yields highly consistent cortical activation patterns: Test-retest reliability of magnetoencephalography recordings.

Reliable paradigms and imaging measures of individual-level brain activity are paramount when reaching from group-level research studies to clinical assessment of individual patients. Magnetoencephalography (MEG) provides a direct, non-invasive measure of cortical processing with high spatiotemporal accuracy, and is thus well suited for assessment of functional brain damage in patients with language difficulties. This MEG study aimed to identify, in a delayed picture naming paradigm, source-localized evoked activity and modulations of cortical oscillations that show high test-retest reliability across measurement days in healthy individuals, demonstrating their applicability in clinical settings. For patients with a language disorder picture naming can be a challenging task. Therefore, we also determined whether a semantic judgment task ('Is this item living?') with a spoken response ("yes"/"no") would suffice to induce comparably consistent activity within brain regions related to language production. The MEG data was collected from 19 healthy participants on two separate days. In picture naming, evoked activity was consistent across measurement days (intraclass correlation coefficient (ICC)>0.4) in the left frontal (400-800 ms after image onset), sensorimotor (200-800 ms), parietal (200-600 ms), temporal (200-800 ms), occipital (400-800 ms) and cingulate (600-800 ms) regions, as well as the right temporal (600-800 ms) region. In the semantic judgment task, consistent evoked activity was spatially more limited, occurring in the left temporal (200-800 ms), sensorimotor (400-800 ms), occipital (400-600 ms) and subparietal (600-800 ms) regions, and the right supramarginal cortex (600-800 ms). The delayed naming task showed typical beta oscillatory suppression in premotor and sensorimotor regions (800-1200 ms) but other consistent modulations of oscillatory activity were mostly observed in posterior cortical regions that have not typically been associated with language processing. The high test-retest consistency of MEG evoked activity in the picture naming task testifies to its applicability in clinical evaluations of language function, as well as in longitudinal MEG studies of language production in clinical and healthy populations.

Improving the efficacy and reliability of rTMS language mapping by increasing the stimulation frequency.

Repetitive TMS (rTMS) with a frequency of 5-10 Hz is widely used for language mapping. However, it may be accompanied by discomfort and is limited in the number and reliability of evoked language errors. We, here, systematically tested the influence of different stimulation frequencies (i.e., 10, 30, and 50 Hz) on tolerability, number, reliability, and cortical distribution of language errors aiming at improved language mapping. 15 right-handed, healthy subjects (m = 8, median age: 29 yrs) were investigated in two sessions, separated by 2-5 days. In each session, 10, 30, and 50 Hz rTMS were applied over the left hemisphere in a randomized order during a picture naming task. Overall, 30 Hz rTMS evoked significantly more errors (20 ± 12%) compared to 50 Hz (12 ± 8%; p <.01), whereas error rates were comparable between 30/50 and 10 Hz (18 ± 11%). Across all conditions, a significantly higher error rate was found in Session 1 (19 ± 13%) compared to Session 2 (13 ± 7%, p <.05). The error rate was poorly reliable between sessions for 10 (intraclass correlation coefficient, ICC = .315) and 30 Hz (ICC = .427), whereas 50 Hz showed a moderate reliability (ICC = .597). Spatial reliability of language errors was low to moderate with a tendency toward increased reliability for higher frequencies, for example, within frontal regions. Compared to 10 Hz, both, 30 and 50 Hz were rated as less painful. Taken together, our data favor the use of rTMS-protocols employing higher frequencies for evoking language errors reliably and with reduced discomfort, depending on the region of interest.