Discovery of metabolite biomarkers for odontogenic keratocysts.

INTRODUCTION: Odontogenic keratocysts (OKCs) are locally aggressive and have a high rate of recurrence, but the pathogenesis of OKCs is not fully understood. We aimed to investigate the serum metabolomic profile of OKCs and discover potential biomarkers. METHODS: Metabolomic analysis was performed on 42 serum samples from 22 OKC patients and 20 healthy controls (HCs) using gas chromatography‒mass spectrometry to identify dysregulated metabolites in the OKC samples. LASSO regression and receiver operating characteristic (ROC) curve analyses were used to select and validate metabolic biomarkers and develop diagnostic models. RESULTS: A total of 73 metabolites were identified in the serum samples, and 24 metabolites were dysregulated in the OKC samples, of which 4 were upregulated. Finally, a diagnostic panel of 10 metabolites was constructed that accurately diagnosed OKCs (sensitivity of 100%, specificity of 100%, area under the curve of 1.00). CONCLUSION: This study is the first to investigate the metabolic characteristics and potential metabolic biomarkers in the serum of OKC patients using GC‒MS. Our study provides further evidence to explore the pathogenesis of OKC.

Pediatric Odontogenic Cysts and Tumors.

Pediatric odontogenic cysts and tumors are rare and often associated with developing or impacted teeth. Odontogenic cysts are broadly categorized as inflammatory or developmental while odontogenic tumors are classified histologically as epithelial, mesenchymal, or mixed tumors. This article will discuss the presentation, diagnosis, and treatment of odontogenic cysts and tumors in the pediatric population.

Transformation of an odontogenic keratocyst into a solid variant of odontogenic keratocyst/keratoameloblastoma during long­term follow­up: A case report.

Keratoameloblastoma (KA) and solid variant of odontogenic keratocyst (SOKC) are rare odontogenic lesions, and their relationship and differences are unclear. The present study described a case that started as an odontogenic keratocyst (OKC) and transformed to SOKC/KA upon recurrence. Briefly, a 26­year­old man presented with swelling in the right cheek and was referred to the Department of Oral and Maxillofacial surgery, Hiroshima University Hospital (Hiroshima, Japan). At the initial visit, unicystic bone permeation was observed extending from the right canine to the molar, maxillary sinus and nasal cavity. After the biopsy, the patient underwent excisional surgery and was diagnosed with OKC. Thereafter, the lesion recurred six times over a period of 13 years and showed different histopathological features from those of the primary lesion, all consisting of numerous cysts with keratinization, which were diagnosed as SOKC/KA. The Ki­67 positivity rate was ~10%, which was higher than that of the primary lesion, but there was no atypia. Genetic analysis of the recurrent lesion revealed mutations in adenomatous polyposis coli and Kirsten rat sarcoma viral oncogene homolog. This case originated from OKC, and the morphological features of OKC and KA were mixed upon recurrence, supporting the commonality and association between the two. However, multiple mutations different from those of OKC and ameloblastoma were detected, suggesting an association of SOKC/KA with increased proliferative activity and a high recurrence rate.

Odontogenic Keratocyst of the Posterior Maxilla: Report of an Unusual Case

ABSTRACT The odontogenic keratocyst is a developmental odontogenic cyst. It can occur anywhere in the jaws, but it is commonly seen in the posterior part of the mandible. Lesions have a propensity to grow along the internal aspect of the jaws, and clinically observable expansion of bone occurs late. These lesions have a different mechanism of growth as compared with other cysts, and may show varying radiographic appearances. This paper reports a distinctive case of an odontogenic keratocyst in a 33-year-old female patient. The cyst has an unusual radiographic presentation of two unilocular radiolucencies overlapping each other in the left maxillary premolar-molar region. The study also presents a literature review.

A Rare Odontogenic Cyst in an Uncommon Area: Case Report and Review of the Literature / Um cisto odontogênico raro em uma área incomum: Relato de caso e revisão da literatura

Abstract Objective Orthokeratinized odontogenic cyst is a rare developmental odontogenic cyst of the jaws. It is a less aggressive intraosseous cyst identified by an orthokeratinized epithelium. Case Report A 50-year-old male patient with the chief complaint of swelling in the anterior part of his face, and, intraorally, there was diffuse swelling in the palatal cortex. On panoramic radiography, there was a well-defined unilocular radiolucency on the right side of the maxilla and palatal cortical expansion, and thinning of the buccal and palatal cortexes was observed. The histopathological examination revealed a pathologic cyst that was lined by a thick orthokeratinized epithelium. Therefore, the diagnosis was orthokeratinized odontogenic cyst. Conclusion The orthokeratinized odontogenic cyst displays characteristic clinical, histopathological, and biological features that differ significantly from those of keratocystic odontogenic tumor (KCOT), but it has a better prognosis and lower recurrence rate. Thus, other radiolucent lesions of the jaws, including keratocystic odontogenic tumor (KCOT), must be considered in the differential diagnosis.

Resumo Objetivo O cisto odontogênico ortoceratinizado é um raro cisto odontogênico maxilar. É um cisto intraósseo menos agressivo, identificado por um epitélio ortoceratinizado. Relato de caso Um paciente do sexo masculino, de 50 anos de idade, com queixa principal de edema na parte anterior da face, e, intraoralmente, havia edema difuso no córtex palatal. Na radiografia panorâmica, havia uma radioluminescência unilocular bem definida no lado direito da maxila e expansão cortical palatina, e desbastamento dos córtex vestibular e palatino. O exame histopatológico revelou cisto patológico revestido por espesso epitélio ortoceratinizado. Logo, o dignóstico foi de cisto odontogênico ortoceratinizado. Conclusão O cisto odontogênico ortoceratinizado apresenta características clínicas, histopatológicas e biológicas que diferem significativamente das do tumor odontogênico ceratocístico (TOC), mas tem melhor prognóstico e menor taxa de recorrência. Portanto, outras lesões radiolúcidas dos maxilares, incluindo TOC, devem ser consideradas no diagnóstico diferencial.

Inflammatory and developmental odontogenic cysts: 23-year observational and retrospective study / Cistos odontogênicos inflamatórios e de desenvolvimento: estudo observacional e retrospectivo de 23 anos

Objective: This observational and retrospective study evaluated the prevalence and characteristics of odontogenic cysts, outlining the epidemiological profile of these lesions. Material and methods: The following data were collected from the medical records of patients with a diagnosis confirmed by microscopy: age, sex, ethnicity, anatomical location, histopathological diagnosis and treatment, between 1995 and 2018. Results: Of the 70 cysts, 75.7% were inflammatory and 24.2% development. The inflammatory periapical cyst was the most prevalent (62.8%) followed by the dentigerous cyst (71.0%). The lateral radicular cysts and odontogenic keratocysts obtained the same percentage (5.7%), followed by the residual cyst (4.3%), paradental (2.8%) and the orthokeratinized variable (1.5%). Women were slightly more affected (1.12: 1) with greater involvement of leucodermas (80%). Age and anatomical location differed according to each lesion, although the anterior maxilla region was more affected. Enucleation was the most used treatment (75.7%), except for odontogenic keratocysts, in which marsupialization was performed in 75% of the cases. Conclusion: Epidemiological data provide an important insight into the prevalence, extent and severity of these lesions, allowing early diagnosis and prevention, in order to guarantee the reduction of cases and improve the quality of life of the population.

Objetivo: Avaliar a prevalência e características dos cistos odontogênicos de forma observacional e retrospectiva, delineando o perfil epidemiológico destas lesões. Material e Métodos: Foram coletados os seguintes dados dos prontuários de pacientes com diagnóstico confirmado microscopicamente: idade, sexo, etnia, localização anatômica, diagnóstico histopatológico e tratamento, entre os anos de 1995 a 2018. Resultados: Dos 70 cistos, 75,7% eram inflamatórios e 24,2% de desenvolvimento. O cisto periapical inflamatório foi o mais prevalente (62,8%) seguido pelo cisto dentígero (71,0%). O cisto radicular lateral e queratocisto odontogênico obtiveram o mesmo percentual (5,7%), seguidos do cisto residual (4,3%), paradentário (2,8%) e a variável ortoqueratinizada (1,5%). As mulheres foram ligeiramente mais afetadas (1,12:1) com maior acometimento de leucodermas (80%). Idade e localização anatômica diferiram de acordo com cada lesão, embora a região anterior de maxila tenha sido mais afetada. A enucleação foi o tratamento mais utilizado (75,7%), exceto para o queratocisto odontogênico, no qual a marsupialização foi realizada em 75% dos casos. Conclusão: Os dados epidemiológicos fornecem uma visão importante para o entendimento da prevalência, extensão e gravidade dessas lesões, viabilizando o diagnóstico precoce e medidas preventivas, a fim de garantir a redução dos casos e melhorar a qualidade de vida da população.

Frecuencia de quistes odontogénicos en pacientes de la Facultad de Odontología, Universidad Nacional de Colombia / Frequency of Odontogenic Cysts in Patients of the National University of Colombia Dental School

Antecedentes: Los quistes odontogénicos se caracterizan por ser asintomáticos. Su hallazgo depende en un 80 % de imágenes radiográficas y en un 20 % de sintomatología esporádica. Colombia presenta pocos datos epidemiológicos sobre esta patología. Objetivo: Describir la frecuencia de los quistes odontogénicos, según la clasificación de la OMS del 2017, en los pacientes de la Facultad de Odontología de la Universidad Nacional de Colombia, sede Bogotá. Métodos: Se realizó un estudio descriptivo de corte transversal. Se seleccionaron historias clínicas con diagnóstico de quiste odontogénico corroborado por análisis histopatológico, y que tuvieran correctamente diligenciados los datos de edad, sexo y localización (zona afectada). Se usó la prueba de Fisher para evaluar independencia entre variables (p=0,05). Resultados: Los quistes odontogénicos más frecuentes fueron: quiste dentígero (66,6 %), quiste radicular (22,2 %) y queratoquiste odontogénico (11,2%). El 77,7 % se diagnosticó en hombres. 38.9 % de ellos se diagnosticaron entre la primera y segunda décadas de la vida (p=0,041) y la zona posterior mandibular fue la más afectada en un 44,4 % (p=0,017). Conclusiones: El quiste dentígero se presentó más durante la segunda década de la vida, en hombres y en la zona mandibular posterior. El quiste radicular no mostró predilección por un sexo, se presentó durante y después de la cuarta década de la vida y afectó la zona maxilar anterior. El queratoquiste odontogénico no tuvo predilección por sexo o zona afectada y se presentó en dos décadas de la vida diferentes.

Background: Odontogenic cysts are asymptomatic. They are diagnosed radiographically (80 %) or through sporadic symptomatology (20 %). There is scarce epidemiological data regarding this pathology in Colombia. Purpose: To describe the frequency of odontogenic cysts, based on the 2017 WHO classification, among patients of the National University of Colombia dental school. Methods: A cross-sectional study was carried out using clinical records of patients with diagnosis of odontogenic cysts (confirmed through histopathological analysis), whose age, sex, and cyst location (affected area) data were correctly completed. Fisher's test was used to evaluate independence between variables (p=0.05). Results: The most frequent odontogenic cysts were: dentigerous cyst (66.6 %), radicular cyst (22.2 %), and odontogenic keratocyst (11.2 %). 77.7 % were observed in men. 38.9 % were diagnosed between the first and second decades of life (p=0.041) and the posterior mandibular area was the most affected (44.4 %) (p=0.017). Conclusions: Dentigerous cyst were found most frequently during the second decade of life, affecting men and the posterior mandibular area. Radicular cysts did not show preference for one gender, occurred during and after the fourth decade of life and affected the anterior maxilla. Odontogenic keratocyst showed no predilection for sex or affected area and was mainly present in two different decades of life.

Quiste odontogénico inflamatorio: aislamiento de Pseudomonas stutzeri. Relevancia diagnóstica / Isolation of Pseudomonas stutzeri from an odontogenic inflammatory cyst: Diagnostic relevance

Pseudomonas stutzeri se encuentra ampliamente distribuido en el medio ambiente, ocupando diversos nichos ecológicos; pero su aparición en procesos infecciosos de interés clínico es el de patógeno oportunista. El aislamiento de P. stutzeri en un quiste inflamatorio odontogénico es un verdadero hallazgo microbiológico que no presenta antecedentes en la bibliografía científica odontológica. En este caso particular, el aislamiento se obtuvo a partir de material quirúrgico proveniente de un quiste odontogénico inflamatorio ubicado en la pieza dentaria 1.2 con necrosis pulpar concomitante. Se emplearon técnicas diagnósticas complementarias como radiografías, tomografías, estudios anatomopatológicos y microbiológicos. Los resultados permitieron clasificar el proceso como quiste inflamatorio infectado con P. stutzeri. La tipificación y la caracterización del perfil de sensibilidad de la cepa aislada permitieron adecuar la terapéutica antibiótica de manera específica. El análisis microbiológico permitió establecer la etiología del proceso infeccioso, la adecuación del tratamiento y el restablecimiento de los tejidos comprometidos.

Pseudomonas stutzeri is distributed widely in the environment, and occupies different ecological niches. However, it is found in clinically relevant infections as an opportunistic pathogen. Isolation of P. stutzeri from an odontogenic inflammatory cyst is an uncommon microbiological finding that has not been reported to date. In the case presented here, the bacterium was isolated from surgical material obtained from excision of an inflammatory odontogenic cyst located in the tooth 1.2, and presenting with concomitant pulp necrosis. Complementary techniques such as radiographs, CAT scans, and histopathological and microbiological studies were used to establish definitive diagnosis. The obtained results allowed classifying the process as an inflammatory cyst infected by P. stutzeri. Biotyping and characterization of the susceptibility profile of the isolated strain allowed adjusting the antibiotic therapy more specifically. The microbiological studies allowed establishing the etiology of the infectious process, adjusting the treatment plan, and re-establishing tissue integrity.

Quiste odontogénico ortoqueratinizado: reporte de un caso / Orthokeratinized odontogenic cyst: report of a case

El quiste odontogénico ortoqueratinizado es un quiste de desarrollo poco común de los maxilares. Descrito en 1956 por Philipsen como una variante del queratoquiste odontogénico (tumor odontogénico queratinizante) y posteriormente identifi cado como una entidad totalmente aparte por Wrigth, sigue siendo hoy en día una lesión en controversia. En este trabajo se reporta el caso de un paciente masculino de 15 años de edad que acude al Servicio de Cirugía Maxilofacial del Hospital Regional®Lic. Adolfo López Mateos¼, ISSSTE, el cual es diagnosticado como un quiste odontogénico ortoqueratinizado. Tener una adecuada ruta clínica para el diagnóstico clínico, complementado por imagen, y sobre todo contar con el resultado de la biopsia incisional son pasos fundamentales para poder diagnosticar y no sobretratar padecimientos que, con procedimientos menos invasivos y agresivos, tienen mejor pronóstico...

Tumor odontogénico queratoquístico: revisión bibliográfica y presentación de un caso / Keratocystic odontogenic tumor: review of the literature and report of a case

La Organización Mundial la Salud (OMS) a través del Centro Internacional de Referencia de los Tumores Odontogénicos en su última clasificación 2005, ha decidido incluir al Quiste Odontogénico queratoquístico Paraqueratinizado dentro del grupo de los Tumores Odontogénicos, como Tumor Odontogénico Queratoquístico y ha permanecido el Quiste Odontogénico Queratoquístico Ortoqueratinizado, como una entidad se-parada dentro de los Quistes Odontogénicos ya existente, es decir uno pasa a ser una neoplasia benigna y otro una entidad quística.Los autores presentamos un caso clínico quirúrgico de un tumor Odontogénico Queratoquístico...

Keratocystic odontogenic tumor: clinicopathological aspects and treatment / Tumor odontogénico queratoquístico: aspectos clínico-patológicos y tratamiento

The keratocystic odontogenic tumor is a benign intraosseous neoplasm derived from remnants of the dental lamina and it occurs with high frequency. Regarding histological characteristics, it has a high recurrence rate which is one of the main therapeutic problems. Also, it presents high local aggressiveness, expressed in cortical expansion, delayed eruption and displacement of teeth, blood vessels and nerves. At present, there are various treatments, being ideal the one which presents the lowest risk of recurrence with low morbidity for the patient. In this review, the main histopathological, clinical and therapeutic aspects of this oral pathology are discussed.

El tumor odontogénico queratoquístico es una neoplasia intraósea benigna que deriva de restos de la lámina dental, y que se presenta con alta frecuencia. Sus características histológicas le confieren una elevada tasa de recidiva, siendo este uno de sus principales problemas terapéuticos. Presenta además una considerable agresividad local, la cual se expresa con la expansión de corticales óseas, retardo en la erupción y desplazamiento de dientes, vasos sanguíneos y nervios. En la actualidad existen diversos tratamientos, siendo el ideal aquel que presente el menor riesgo de recidiva con una baja morbilidad para el paciente. En la presente revisión se discuten los principales aspectos histopatológicos, clínicos y terapéuticos de esta patología oral.

Tumor odontogénico queratoquístico: revisión de la literatura a propósito de un caso clínico / Keratocystic odontogenic tumor: a review of the literature in reference to a clinical case

El Tumor odontogénico queratoquístico es una entidad benigna de prevalencia relativamente alta que surge desde los remanentes de la lámina dental, el cual tiene un potencial comportamiento agresivo y alta recurrencia. Este tiende a crecer lentamente dentro del canal medular en sentido anteroposterior transformándose en una gran lesión sin causar una expansión obvia. Esta revisión describe la clínica, imagenología y tratamientos actuales del Tumor Odontogénico Queratoquístico a propósito de un paciente de sexo masculino 30 años diagnosticado con esta entidad.

Keratocystic Odontogenic tumor is a benign entity with relatively high prevalence that arises from remains of dental lamina. It has a potentially aggressive behaviour, high recurrence and anteroposterior slow growth in the medullar canal, which can become large lesion without obvious expansion. This review describes clinical, imagenological and current treatments of Keratocystic Odontogenic Tumor in 30- year-old male patient diagnosed with this entity.

Uso del marcador KI-67 en la toma de decisión del tratamiento de tumor odontogénico quístico queratinizante: presentación de un caso / Use of KI-67 marker in decision making treatment keratinizing cystic odontogenic tumor: a case

El Tumor Odontogénico Quístico Queratinizante (TOQQ) es un tumor benigno de origen odontogénico, el cual fue considerado hasta muy recientemente una lesión quística denominada Queratoquiste odontogénico. El TOQQ es considerado un tumor de estructura quística, sin embargo, debido a su agresivo comportamiento clínico y el alto porcentaje de recurrencia el tratamiento varia desde la enucleación de la lesión hasta la eliminación radical total del hueso afectado. El propósito de este trabajo es la descripción de un caso en paciente femenina de 34 años de edad quien presentó imagen radiolúcida multilocular extensa que ocupó cuerpo y rama mandibular, cuyo estudio histopatológico, previa biopsia incisional, concluyó TOQQ. Se realizó la determinación de Ki-67 mediante inmunohistoquímica para planificar el tratamiento quirúrgico. La baja expresión de Ki-67, a pesar de la extensión de la lesión, fueron los criterios para la realización de tratamiento conservador. La paciente se encuentra sin recidiva después de 5 años de realizado el procedimiento quirúrgico.

Cisto gengival do adulto: diagnóstico diferencial com fístulas, abscessos, mucoceles e neoplasias / Gingival cyst of the adult: differential diagnosis with fístulas, abscesses, mucoceles and neoplasias

O cisto gengival do adulto nem sempre é notado, devido ao seu crescimento limitado e ausência de sintomatologia. Em quase todos os casos, está localizado na face vestibular. O diagnóstico diferencial inclui mucocele, abscesso gengival, fístulas e algumas neoplasias benignas. Os adenomas, neuromas e neoplasias ou cistos odontogênicos periféricos podem se localizar nos tecidos gengivais e, quando ainda são pequenos e detectáveis, podem simular o cisto gengival do adulto. Esse apresenta-se como uma tumefação arredondada, em forma de domo, bem delimitada e firme à palpação, localizada nos tecidos gengivais, especialmente na gengiva aderida. Localiza- -se quase sempre na região dos pré-molares e caninos inferiores ou em suas áreas imediatamente vizinhas; em uma minoria de casos, pode ocorrer na mesma região da maxila. A maioria dos pacientes tem mais de 40 anos de idade, independentemente do sexo, mas qualquer idade pode ser afetada; eventualmente é bilateral. O cisto gengival do adulto deve ser incluído no diagnóstico diferencial de casos em que a nodulação ou tumefação localizada na gengiva aderida não se relaciona com nenhum dente com necrose pulpar, e depois que a possibilidade de abscesso gengival ou periodontal tiver sido descartada, pela presença de saúde plena dos tecidos periodontais. A conduta frente ao cisto gengival do adulto deve ser sua remoção cirúrgica completa e posterior análise microscópica. O prognóstico tende a ser muito bom e não há casos de transformação agressiva ou malignização.

Aplicabilidade da técnica de cell block na avaliação citológica do conteúdo de lesões de aspecto cístico dos maxilares / Applicability of cell block technique for cytological evaluation of biological material collected from maxillary cystic lesions

INTRODUÇÃO: A busca por novos métodos que auxiliem e simplifiquem de maneira eficaz o diagnóstico de lesões maxilares, cistos e tumores, objetiva beneficiar os pacientes e facilitar a atuação dos profissionais da área de diagnóstico bucal. Além dos dados clínicos, radiográficos e histopatológicos classicamente utilizados nos protocolos de investigação das lesões maxilares, a adaptação de técnicas já consagradas na medicina pode ser de grande valia. A técnica de cell block se propõe a auxiliar nesse processo, pois consiste na análise citológica de materiais, efusões e líquidos, coletados de lesões passíveis de punção aspirativa, como cistos e tumores císticos dos maxilares. OBJETIVO: Demonstrar a aplicabilidade da técnica de cell block para avaliação citológica de material biológico coletado a partir de lesões císticas dos maxilares. RESULTADOS: Das 20 lesões, das quais o conteúdo foi processado pela técnica, a avaliação citológica de cinco casos de tumores odontogênicos ceratocísticos (TOCs) demonstrou a presença predominante de ceratina, sempre com áreas de paraceratina. Nos demais casos (cinco cistos dentígeros, cinco cistos radiculares e cinco cistos residuais) foi observada a presença de hemácias, células inflamatórias e fendas de cristais de colesterol. CONCLUSÃO: A avaliação citológica, a partir da técnica de cell block, foi útil no estabelecimento do diagnóstico diferencial entre TOC e demais lesões estudadas, cistos radicular, residual e dentígero.

INTRODUCTION: The search for new methods that aid and optimize the diagnosis of cystic and tumoral maxillary lesions aims to benefit both patients and professionals from oral diagnosis. In addition to clinical, radiographic and histological findings traditionally used in research protocol for maxillary lesions, the adaptation of widely used medical techniques may be very helpful. The cell block procedure streamlines this process, inasmuch as it consists of cytopathological analysis of materials, liquids and effusions, collected from aspirated lesions such as maxillary cysts and cystic maxillary tumors. OBJECTIVE: To demonstrate the applicability of cell block technique for cytological assessment of biological material collected from cystic maxillary lesions. RESULTS: The cytological evaluation revealed that five out of 20 lesions, whose content had been processed by this technique, were odontogenic keratocystic tumors (TOCs), predominantly with keratin and always with parakeratin areas. In the other cases (five dentigerous, five radicular and five residual cysts) there were erythrocytes, inflammatory cells, and cholesterol clefts. CONCLUSION: The cytological assessment through cell block technique was useful as to establishing the differential diagnosis between TOC and other lesions, radicular, residual and dentigerous cysts.

Cell block technique as a complementary method in the clinical diagnosis of cyst-like lesions of the jaw

OBJECTIVE: To evaluate the applicability of the cell block technique as a complementary method for presumptive diagnosis in the analysis of cyst-like aspirates from jaw lesions prior to histopathological diagnosis. MATERIAL AND METHODS: The sample was made up of 17 cyst-like jaw lesions. After puncture, the aspirates were centrifuged, fixed in formalin, embedded in paraffin and processed. All lesions were biopsied and submitted to histopathological examination. RESULTS: In 9 cases, the cytopathological analysis using the cell block method showed a predominant presence of erythrocytes, inflammatory cells and few epithelial cells. In the other 8 cases, the cell block technique demonstrated the presence of parakeratin, whose histopathological analysis confirmed the occurrence of keratocystic odontogenic tumors (KOTs). CONCLUSIONS: According to the studied cases, the cell block method was proven to be a simple, fast and low-cost technique to effectively differentiate KOTs from other lesions with similar clinical and radiographic features. The cell block technique comprises cellular preparations useful to determine a clinical diagnosis and help to develop a therapeutic plan for those lesions.

Synchronous pleomorphic adenoma and periapical cyst: clinical case report / Adenoma pleomorfo e cisto periapical sincrônicos: relato de caso clínico

The pleomorphic adenoma or mixed benign tumor is the most common benign neoplasia of the salivary gland in human beings. It preferentially occurs in the superficial lobe of the parotid gland. In the oral cavity, associated with the minor salivary glands, it has a greater predilection for the palate region, with slight predisposition in women between the 3rd and 4th decades of life. The radicular cyst is an odontogenic inflammatory cyst resulting from pulp lesions caused by traumas or caries. In spite of being relatively common, there are no reports of association with salivary gland tumors. The aim of this work is to report a case of a 36-year-old woman patient, who presented with synchronous development of a pleomorphic adenoma and periapical cyst within the same region. The option taken was to perform enucleation of both lesions,followed by local curettage. The patient has been followed-up clinically and radiographically for around 18 months without signs of recurrence.

O adenoma pleomórfico ou tumor misto benigno é a neoplasia benigna mais comum primária de glândula salivar. Ocorre preferencialmente no lobo superficial da glândula parótida. Na cavidade oral, associado com as glândulas salivares menores, tem uma maior predileção para a região do palato, com ligeira predisposição em mulheres entre a 3 ª e 4 ª décadas de vida. O cisto radicular é um cisto odontogênico inflamatório decorrente de lesões causadas por traumas ou cárie. Apesar de ser relativamente comum, não há relatos de cistos periapicais associados com tumores de glândula salivar. O objetivo deste artigo é relatar um caso de uma paciente de 36 anos de idade com desenvolvimento sincrônico de adenoma pleomorfo e cisto periapical em uma mesma região. A opção tomada foi a de realizar a enucleação de ambas as lesões, seguido de curetagem local. A paciente está sendo acompanhada clínica e radiograficamente por cerca de 18 meses sem sinais de recidiva.

Cisto periodontal lateral: relato de caso / Lateral periodontal cyst: case report

Although the majority of cystic jaw lesions are well studied, discussed and defined, the Lateral Periodontal Cystis a relatively uncommon lesion and its etiology has not been yet clarified. For the rarity of the lesion, a case ofLateral Periodontal Cyst is reported with focus on clinical, radiographic and microscopic aspects.

Apesar da maioria das lesões císticas maxilares serem bem estudadas, discutidas e definidas, o Cisto Periodontal Lateral é uma lesão relativamente incomum e ainda não tem sua etiologia esclarecida. Pela raridade da lesão, um caso clínico de Cisto Periodontal Lateral é relatado com enfoque nos aspectos clínicos, radiográficos e microscópicos.

Alterações bucais mais frequentes no bebê: relato de dois casos de cistos de inclusão / More frequent oral alterations in the baby: two cases report of inclusion cysts

Introdução: Os cistos de inclusão do recém-nascido são observados em grupos de dois a seis cistos, embora as lesões possam ocorrer isoladamente, de coloração branca, branco-amarelada ou acinzentada, localizadas na mucosa bucal, podendo desaparecer ainda na fase intrauterina e ser classificadas, de acordo com a localização, como: nódulos de Bohn, cistos da lâmina dentária e pérolas de Epstein. O objetivo deste artigo é relatar dois casos de cistos de inclusão em bebês, diagnosticados como nódulos de Bohn e cistos da lâmina dentária. As lesões são inócuas e nenhum tratamento é necessário. Conclusão: Considerando-se que os cistos de inclusão são alterações frequentes na cavidade oral dos bebês, conclui-se ser imprescindível que odontopediatras e profissionais que atendem crianças nessa faixa etária os reconheçam, atentando para a necessidade de intervenção e, sobretudo, de tranquilizar os pais, normalmente preocupados ao observar essas anomalias em seus filhos.

Introduction: The cysts of inclusion of the newborn are observed in groups from two to six cysts, although the lesions can happen separately, of coloration white, white-yellowish or grayish, located in the mouth mucosa, and could still disappear in the intra-uterine phase, and they can be classified, in agreement with the location, as: nodules of Bohn, cysts of the dental sheet and Epstein pearls. The objective of this article is to report two cases of inclusion cysts in babies, diagnosed as nodules of Bohn and cysts of the dental sheet. The lesions are innocuous and no treatment is necessary. Conclusion: Being considered that the inclusion cysts are frequent alterations in the babies' oral cavity, it is concluded to be indispensable that pediatric dentists and professionals that assist children in this age group recognize them, looking at the intervention need and, above all, in the sense of tranquilizing the parents, usually concerned when observing those anomalies in their children.

Cisto radicular inflamatório extenso envolvendo seio maxilar / Large radicular cyst involving the maxillary sinus

O cisto radicular é o cisto odontogênico de maior significado clínico para o cirurgião-dentista. Por ser a lesão cística inflamatória mais frequentemente encontrada dos maxilares, é a mais tratada. Ocorre nos ápices de dentes infectados em decorrência à necrose pulpar. Embora o cisto radicular faça parte do cotidiano do clínico, há poucos trabalhos descrevendo as suas características clínicas e tomográficas. Assim, o objetivo deste trabalho é o de apresentar um cisto radicular extenso com envolvimento do seio maxilar e cavidade nasal cujo exame de tomografia computadorizada por feixe cônico foi essencial para o delineamento do plano de tratamento...

The radicular cyst is the odontogenic lesion with major clinical significance for the dental surgeon. Once this is the most common inflammatory cystic lesion, the radicular cyst is the most treated one. It affects the apical portion of infected teeth after the pulp necrosis. Although the radicular cyst is part of the routine of the dental practice, there are only few studies describing its clinical and thomographic features. Thus, the aim of this work is to report an extensive radicular cyst involving the maxillary sinus and nasal cavity which cone bean computerized tomography was essential for the surgical planning...