RESUMO
SAMPLE: Fifty-three third and fourth graders from China participated in this study. METHOD: Participants' working memory (WM) was assessed by the Automated Operation Span task. Then, they solved mental addition problems of different types under low- and high-pressure conditions. Performance was analysed as a function of pressure condition, working memory capacity, and problem type. RESULTS: On 'no carry' mental addition problems, there was no difference between the two groups of children regardless the presence of pressure. For problems with carries, low WM (LWM) children performed worse on all tasks compared with high WM (HWM) children in the no-pressure condition, but pressure influenced the LWM and HWM differently depending on the nature of the carrying task. On 'hidden carry' mental addition trials (for which guessing strategies were minimally effective), LWM performance was much lower than HWM performance under pressure. By contrast, performance was similar between LWM and HWM groups under pressure on the 'normal carry' trials that allowed for non-resource-intensive heuristic strategies. CONCLUSION: Whether high- or low-working-memory elementary-school-aged children were more or less affected by pressure was dependent on task-difficulty and the types of strategies that could be used to solve the problems.
Assuntos
Memória de Curto Prazo/classificação , Resolução de Problemas/classificação , Estresse Psicológico/psicologia , Estudantes/psicologia , Análise de Variância , Criança , China , Feminino , Humanos , Masculino , Matemática/métodos , Matemática/estatística & dados numéricos , Tempo de Reação , Estudantes/estatística & dados numéricos , Análise e Desempenho de TarefasRESUMO
BACKGROUND: Metacognition and working memory (WM) have been found associated with success in reading comprehension, but no studies have examined their combined effect on the training of reading comprehension. Another open question concerns the role of listening comprehension: In particular, it is not clear whether training to improve reading comprehension must necessarily be based on processing written material or whether, as suggested in a recent study by Clarke et al. (2010, Psychol. Sci., 21, 1106), a programme based on verbal language could also be effective. AIMS: The study examined the feasibility of improving text comprehension in school children by comparing the efficacy of two training programmes, both involving metacognition and WM, but one based on listening comprehension, the other on reading comprehension. PARTICIPANTS: The study involved a sample of 159 pupils attending eight classes in the fourth and fifth grades (age range 9-11 years). METHOD: The listening and reading programmes focused on the same abilities/processes strictly related to text comprehension, and particularly metacognitive knowledge and control, WM (per se and in terms of integrating information in a text). The training programmes were implemented by school teachers as part of the class's normal school activities, under the supervision of experts. Their efficacy was compared with the results obtained in an active control group that completed standard text comprehension activities. RESULTS: Our results showed that both the training programmes focusing on specific text comprehension skills were effective in improving the children's achievement, but training in reading comprehension generated greater gains than the listening comprehension programme. CONCLUSIONS: Our study suggests that activities focusing specifically on metacognition and WM could foster text comprehension, but the potential benefit is influenced by the training modality, that is, the Reading group obtained greater and longer-lasting improvements than the Active control or Listening groups.
Assuntos
Compreensão/classificação , Aprendizagem/classificação , Memória de Curto Prazo/classificação , Leitura , Análise e Desempenho de Tarefas , Ensino/organização & administração , Análise de Variância , Criança , Tomada de Decisões , Estudos de Viabilidade , Feminino , Humanos , Masculino , Avaliação de Programas e Projetos de Saúde/métodos , Percepção da FalaRESUMO
Individuals with mild traumatic brain injury (TBI) often have deficits in processing speed and working memory (WM) and there is a growing literature using functional imaging studies to document these deficits. However, divergent results from these studies revealed both hypoactivation and hyperactivation of neural resources after injury. We hypothesized that at least part of this variance can be explained by distinct demands between WM tasks. Notably, in this literature some WM tasks use discrete periods of encoding, maintenance, and retrieval, whereas others place continuous demands on WM. The purpose of this meta-analysis is to examine the differences in neural recruitment after mTBI to determine if divergent findings can be explained as a function of task demand and cognitive load. A comprehensive literature review revealed 14 studies using functional magnetic resonance imaging to examine brain activity of individuals with mTBI during working memory tasks. Three of the fourteen studies included reported hypoactivity, five reported hyperactivity, and the remaining six reported both hypoactivity and hyperactivity. Studies were grouped according to task type and submitted to GingerALE maximum likelihood meta-analyses to determine the most consistent brain activation patterns. The primary findings from this meta-analysis suggest that the discrepancy in activation patterns is at least partially attributable to the classification of WM task, with hyperactivation being observed in continuous tasks and hypoactivation being observed during discrete tasks. We anticipate that differential task load expressed in continuous and discrete WM tasks contributes to these differences. Implications for the interpretation of fMRI signals in clinical samples are discussed.
Assuntos
Lesões Encefálicas/fisiopatologia , Encéfalo/fisiopatologia , Imageamento por Ressonância Magnética/estatística & dados numéricos , Memória de Curto Prazo/fisiologia , Humanos , Memória de Curto Prazo/classificaçãoRESUMO
Although few studies have systematically investigated the relationship between visual mental imagery and visual working memory, work on the effects of passive visual interference has generally demonstrated a dissociation between the two functions. In four experiments, we investigated a possible commonality between the two functions: We asked whether both rely on depictive representations. Participants judged the visual properties of letters using visual mental images or pictures of unfamiliar letters stored in short-term memory. Participants performed both tasks with two different types of interference: sequences of unstructured visual masks (consisting of randomly changing white and black dots) or sequences of structured visual masks (consisting of fragments of letters). The structured visual noise contained elements of depictive representations (i.e., shape fragments arrayed in space), and hence should interfere with stored depictive representations; the unstructured visual noise did not contain such elements, and thus should not interfere as much with such stored representations. Participants did in fact make more errors in both tasks with sequences of structured visual masks. Various controls converged in demonstrating that in both tasks participants used representations that depicted the shapes of the letters. These findings not only constrain theories of visual mental imagery and visual working memory, but also have direct implications for why some studies have failed to find that dynamic visual noise interferes with visual working memory.
Assuntos
Imaginação/fisiologia , Memória de Curto Prazo/fisiologia , Reconhecimento Visual de Modelos/fisiologia , Percepção Visual/fisiologia , Adulto , Percepção Auditiva/fisiologia , Feminino , Humanos , Imaginação/classificação , Masculino , Memória de Curto Prazo/classificação , Testes Neuropsicológicos , Adulto JovemRESUMO
Strategy selection may help explain performance differences between individuals with high working memory capacity (HWMs) and low working memory capacity (LWMs) (Budd, Whitney, & Turley, (Memory & Cognition, 23, 735-748 1995); Cokely, Kelley, & Gilchrist, (Psychonomic Bulletin & Review, 13, 991-997 2006). We compared the independent and spontaneous strategy use of HWMs and LWMs during a category fluency (retrieval) task that required participants to retrieve animal names. HWMs were more successful at the fluency task under normal conditions, but under increased cognitive load, there were no WM-related performance differences. One strategy (i.e., retrieving animals according to their scientific classification) significantly aided performance, irrespective of cognitive load. Under normal conditions, HWMs were more likely to use the effective strategy; however, under load, WM did not predict strategy use. Use of the classification strategy was more strongly related to retrieval performance than was WM. These results suggest that retrieval strategy use is related to WM capacity, and that employing a successful strategy may make up for WM disadvantages during a demanding retrieval task.
Assuntos
Formação de Conceito/fisiologia , Memória de Curto Prazo/fisiologia , Rememoração Mental/fisiologia , Adulto , Humanos , Individualidade , Modelos Lineares , Memória de Longo Prazo/fisiologia , Memória de Curto Prazo/classificação , Rememoração Mental/classificação , Testes Psicológicos , Semântica , Inquéritos e Questionários , Adulto JovemRESUMO
Despite the existence of numerous studies that examined the relationship between working memory capacity and performance in complex cognitive tasks, it remains unclear whether this capacity is domain specific or domain general. In addition, the available empirical evidence is somewhat contradictory. In this work we have studied the role of verbal working memory capacity in a non-verbal task--mental image rotation. If this capacity were domain specific it would be expected that high and low verbal span participants would obtain similar results in the mental rotation task. We have found that this is not the case as the high span participants performed better in terms of both speed and accuracy. Moreover, these differences depended on the processing component of the mental rotation task: the higher the processing requirements the higher the differences as a function of the working memory capacity. Therefore, the evidence presented here supports the domain general hypothesis.
Assuntos
Imaginação/fisiologia , Memória de Curto Prazo/fisiologia , Desempenho Psicomotor/fisiologia , Adolescente , Adulto , Humanos , Individualidade , Masculino , Memória de Curto Prazo/classificação , Testes Neuropsicológicos , Rotação , Percepção Espacial/fisiologia , Adulto JovemRESUMO
Working memory (WM) deficits are a neuropsychological core finding in patients with schizophrenia and also supposed to be a potential endophenotype of schizophrenia. Yet, there is a large heterogeneity between different WM tasks which is partly due to the lack of process specificity of the tasks applied. Therefore, we investigated WM functioning in patients with schizophrenia using process- and circuit-specific tasks. Thirty-one patients with schizophrenia and 47 controls were tested with respect to different aspects of verbal and visuospatial working memory using modified Sternberg paradigms in a computer-based behavioural experiment. Total group analysis revealed significant impairment of patients with schizophrenia in each of the tested WM components. Furthermore, we were able to identify subgroups of patients showing different patterns of selective deficits. Patients with schizophrenia exhibit specific and, in part, selective WM deficits with indirect but conclusive evidence of dysfunctions of the underlying neural networks. These deficits are present in tasks requiring only maintenance of verbal or visuospatial information. In contrast to a seemingly global working memory deficit, individual analysis revealed differential patterns of working memory impairments in patients with schizophrenia.
Assuntos
Transtornos da Memória/etiologia , Memória de Curto Prazo/fisiologia , Esquizofrenia/complicações , Percepção Espacial/fisiologia , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Memória de Curto Prazo/classificação , Pessoa de Meia-Idade , Testes Neuropsicológicos , Estimulação Luminosa/métodos , Escalas de Graduação Psiquiátrica , Estatística como Assunto , Aprendizagem Verbal/fisiologia , Adulto JovemRESUMO
Following Ebbinghaus (1885/1964), a number of procedures have been devised to measure short-term memory using immediate serial recall: digit span, Knox's (1913) cube imitation test and Corsi's (1972) blocks task. Understanding the cognitive processes involved in these tasks was obstructed initially by the lack of a coherent concept of short-term memory and later by the mistaken assumption that short-term and long-term memory reflected distinct processes as well as different kinds of experimental task. Despite its apparent conceptual simplicity, a variety of cognitive mechanisms are responsible for short-term memory, and contemporary theories of working memory have helped to clarify these. Contrary to the earliest writings on the subject, measures of short-term memory do not provide a simple measure of mental capacity, but they do provide a way of understanding some of the key mechanisms underlying human cognition.
Assuntos
Cognição/classificação , Memória de Curto Prazo/classificação , Testes Neuropsicológicos/história , Psicologia Experimental/história , Escalas de Wechsler/história , Animais , História do Século XIX , História do Século XX , História do Século XXI , Humanos , Psicologia Experimental/métodosRESUMO
This review presents neuroimaging studies which have explored the cerebral substrates of the central executive component of the working memory model proposed by Baddeley and Hitch [Working memory (1986); Recent advances in learning and motivation (1974)]. These studies have demonstrated that different executive functions (manipulating and updating of information, dual-task coordination, inhibition and shifting processes) not only recruit various frontal areas, but also depend upon posterior (mainly parietal) regions. Such results are in agreement with the hypothesis that executive functions rely on a distributed cerebral network not restricted to anterior cerebral areas. Moreover, the intervention of similar prefrontal regions in a large number of executive tasks suggests that the central executive functioning must be understood in terms of different interactions between a network of regions rather than in terms of a specific association between one region and one higher-level cognitive process.
Assuntos
Encéfalo/fisiologia , Memória de Curto Prazo/fisiologia , Encéfalo/anatomia & histologia , Lobo Frontal/anatomia & histologia , Lobo Frontal/fisiologia , Humanos , Imageamento por Ressonância Magnética , Memória de Curto Prazo/classificação , Vias Neurais/fisiologia , Lobo Parietal/anatomia & histologia , Lobo Parietal/fisiologia , Tomografia Computadorizada de EmissãoRESUMO
Immediate and delayed recognition memory for words was examined in a sample of 16 non-demented patients with Parkinson's disease and 16 normal control participants of equivalent age and educational attainment. The patients, relative to control participants, had intact immediate but impaired delayed recognition memory performance. Patients were also impaired on tests of free and cued recall, working memory and a measure of psychomotor processing speed. Processing speed was a significant covariate for delayed recognition, free and cued recall and working memory performance, but not for immediate recognition performance. These results suggest that the same cognitive processes which support performance on tests of recall and working memory also support performance on tests of delayed recognition.
Assuntos
Transtornos da Memória/fisiopatologia , Memória de Curto Prazo/classificação , Doença de Parkinson/fisiopatologia , Idoso , Análise de Variância , Gânglios da Base/fisiopatologia , Córtex Cerebral/fisiopatologia , Transtornos Cognitivos/fisiopatologia , Feminino , Humanos , Masculino , Rede Nervosa , Desempenho Psicomotor/fisiologiaRESUMO
Based on the converging evidence supporting the view of domain specific object and spatial working memory processes, the question was addressed whether the property of domain specificity holds equally for temporal information. Using a selective interference paradigm the objective was to test a dissociation of the processing of temporal duration and spatial location information in working memory of intact human subjects. Subjects performed a temporal and a spatial memory task in which they were required to indicate whether the study and the test stimuli were the same or different in duration (temporal memory) or in location (spatial memory) as primary tasks. Both primary tasks were combined with three types of interference tasks, a spatial classification memory task, a temporal classification memory task and a non-interference baseline task--to be performed in-between the presentation of study and test stimuli. Memory for temporal duration was shown to be impaired by the temporal classification task but not by the spatial classification task; memory for spatial position showed the opposite pattern of impairment. These data thus provide evidence for the view that temporal and spatial working memory contents are subject to selective interference, reflecting a functional dissociation in the processing of temporal duration and spatial location information. The results are interpreted as evidence for the domain specificity in the processing of temporal information in working memory.
Assuntos
Atenção/fisiologia , Memória de Curto Prazo/classificação , Memória de Curto Prazo/fisiologia , Mascaramento Perceptivo/fisiologia , Volição/fisiologia , Adulto , Análise de Variância , Sinais (Psicologia) , Discriminação Psicológica/fisiologia , Feminino , Humanos , Masculino , Percepção Espacial/fisiologia , Fatores de Tempo , Percepção do Tempo/fisiologiaRESUMO
Twelve neurologically normal participants (4 men and 8 women) performed semantic, phonological, and orthographic working memory tasks and a control task during functional magnetic resonance imaging. Divergent regions of the posterior left hemisphere used for decoding and storage of information emerged in each working memory versus control task comparison. These regions were consistent with previous literature on processing mechanisms for semantic, phonological, and orthographic information. Further, working memory versus control task differences extended into the left frontal lobe, including premotor cortex, and even into subcortical structures. Findings were consistent with R. C. Martin and C. Romani's (1994) contention that different forms of verbal working memory exist and further suggest that a reconceptualization of premotor cortex functions is needed.
Assuntos
Mapeamento Encefálico/métodos , Lobo Frontal/anatomia & histologia , Imageamento por Ressonância Magnética/métodos , Memória de Curto Prazo/fisiologia , Psicolinguística/métodos , Aprendizagem Verbal/fisiologia , Adolescente , Adulto , Dominância Cerebral/fisiologia , Feminino , Lobo Frontal/fisiologia , Humanos , Processamento de Imagem Assistida por Computador , Masculino , Memória de Curto Prazo/classificação , Córtex Pré-Frontal/anatomia & histologia , Córtex Pré-Frontal/fisiologia , Desempenho Psicomotor/fisiologia , Valores de Referência , Testes de Associação de PalavrasRESUMO
The current study used latent profile analysis (LPA) to ascertain distinct groups of children with ADHD (N = 701) in terms of performance on working memory (WM) tasks that tapped visuospatial sketchpad, spatial central executive, and verbal central executive functions. It compared the WM performances of these classes with a clinical comparison group (N = 59). The participants' age ranged from 7 to 16 years (586 males, 71 females). The results of the LPA supported three classes. For all three WM tasks, class 1 (N = 196) had more difficulties than classes 2 (N = 394) and 3 (N = 111), and the clinical comparison group. Class 2 had more difficulties than class 3 and the clinical comparison group, and there was no difference between class 3 and the clinical comparison group. Class 1 had lower IQ and academic abilities, and relatively more individuals with depressive disorders. The implications of the findings for understanding ADHD and its treatment are discussed.
Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/fisiopatologia , Memória de Curto Prazo/fisiologia , Desempenho Psicomotor/fisiologia , Adolescente , Transtorno do Deficit de Atenção com Hiperatividade/classificação , Criança , Feminino , Humanos , Masculino , Memória de Curto Prazo/classificação , Desempenho Psicomotor/classificaçãoRESUMO
Fragile visual short-term memory (FM) is a recently discovered form of visual short-term memory. Evidence suggests that it provides rich and high-capacity storage, like iconic memory, yet it exists, without interference, almost as long as visual working memory. In the present study, we sought to unveil the functional underpinnings of this memory storage. We found that FM is only completely erased when the new visual scene appears at the same location and consists of the same objects as the to-be-recalled information. This result has two important implications: First, it shows that FM is an object- and location-specific store, and second, it suggests that FM might be used in everyday life when the presentation of visual information is appropriately designed.
Assuntos
Memória de Curto Prazo/fisiologia , Rememoração Mental/fisiologia , Percepção Espacial/fisiologia , Percepção Visual/fisiologia , Adolescente , Adulto , Feminino , Humanos , Masculino , Memória de Curto Prazo/classificação , Adulto JovemRESUMO
Younger and older adults who were either monolingual or bilingual were tested with verbal and spatial working memory (WM) span tasks. Aging was associated with a greater decline in spatial WM than in verbal WM, but the age-related declines were equivalent in both language groups. The bilingual participants outperformed the monolinguals in spatial WM, but achieved lower levels of performance than monolinguals in verbal WM. This interaction between bilingualism and WM domain was also consistent across the adult life span. These results are discussed in terms of the interactions between a domain-general executive processing advantage for bilinguals and the domain-specific content of particular WM tasks.
Assuntos
Envelhecimento/fisiologia , Memória de Curto Prazo/fisiologia , Multilinguismo , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Memória de Curto Prazo/classificação , Rememoração Mental/fisiologia , Pessoa de Meia-Idade , Testes Neuropsicológicos , Psicolinguística/instrumentação , Percepção Espacial/fisiologia , Adulto JovemRESUMO
People often rely on information that is no longer in view, but maintained in visual short-term memory (VSTM). Traditionally, VSTM is thought to operate on either a short time-scale with high capacity - iconic memory - or a long time scale with small capacity - visual working memory. Recent research suggests that in addition, an intermediate stage of memory in between iconic memory and visual working memory exists. This intermediate stage has a large capacity and a lifetime of several seconds, but is easily overwritten by new stimulation. We therefore termed it fragile VSTM. In previous studies, fragile VSTM has been dissociated from iconic memory by the characteristics of the memory trace. In the present study, we dissociated fragile VSTM from visual working memory by showing a differentiation in their dependency on attention. A decrease in attention during presentation of the stimulus array greatly reduced the capacity of visual working memory, while this had only a small effect on the capacity of fragile VSTM. We conclude that fragile VSTM is a separate memory store from visual working memory. Thus, a tripartite division of VSTM appears to be in place, comprising iconic memory, fragile VSTM and visual working memory.
Assuntos
Atenção/fisiologia , Discriminação Psicológica/fisiologia , Memória de Curto Prazo/fisiologia , Mascaramento Perceptivo/fisiologia , Análise de Variância , Sinais (Psicologia) , Área de Dependência-Independência , Humanos , Memória de Curto Prazo/classificação , Valores de Referência , Fatores de TempoRESUMO
To guide our behavior in successful ways, we often need to rely on information that is no longer in view, but maintained in visual short-term memory (VSTM). While VSTM is usually broken down into iconic memory (brief and high-capacity store) and visual working memory (sustained, yet limited-capacity store), recent studies have suggested the existence of an additional and intermediate form of VSTM that depends on activity in extrastriate cortex. In previous work, we have shown that this fragile form of VSTM can be dissociated from iconic memory. In the present study, we provide evidence that fragile VSTM is different from visual working memory as magnetic stimulation of the right dorsolateral prefrontal cortex (DLPFC) disrupts visual working memory, while leaving fragile VSTM intact. In addition, we observed that people with high DLPFC activity had superior working memory capacity compared to people with low DLPFC activity, and only people with high DLPFC activity really showed a reduction in working memory capacity in response to magnetic stimulation. Altogether, this study shows that VSTM consists of three stages that have clearly different characteristics and rely on different neural structures. On the methodological side, we show that it is possible to predict individual susceptibility to magnetic stimulation based on functional MRI activity.
Assuntos
Discriminação Psicológica/fisiologia , Memória de Curto Prazo/fisiologia , Córtex Pré-Frontal/fisiologia , Percepção Visual/fisiologia , Adulto , Feminino , Lateralidade Funcional , Humanos , Imageamento por Ressonância Magnética , Masculino , Memória de Curto Prazo/classificação , Valores de Referência , Estimulação Magnética TranscranianaRESUMO
Stimulant and non-stimulant drugs can reduce symptoms of attention deficit/hyperactivity disorder (ADHD). The stimulant drug methylphenidate (MPH) and the non-stimulant drug atomoxetine (ATX) are both widely used for ADHD treatment, but their differential effects on human brain function remain unclear. We combined event-related fMRI with multivariate pattern recognition to characterize the effects of MPH and ATX in healthy volunteers performing a rewarded working memory (WM) task. The effects of MPH and ATX on WM were strongly dependent on their behavioral context. During non-rewarded trials, only MPH could be discriminated from placebo (PLC), with MPH producing a similar activation pattern to reward. During rewarded trials both drugs produced the opposite effect to reward, that is, attenuating WM networks and enhancing task-related deactivations (TRDs) in regions consistent with the default mode network (DMN). The drugs could be directly discriminated during the delay component of rewarded trials: MPH produced greater activity in WM networks and ATX produced greater activity in the DMN. Our data provide evidence that: (1) MPH and ATX have prominent effects during rewarded WM in task-activated and -deactivated networks; (2) during the delay component of rewarded trials, MPH and ATX have opposing effects on activated and deactivated networks: MPH enhances TRDs more than ATX, whereas ATX attenuates WM networks more than MPH; and (3) MPH mimics reward during encoding. Thus, interactions between drug effects and motivational state are crucial in defining the effects of MPH and ATX.
Assuntos
Memória de Curto Prazo/efeitos dos fármacos , Metilfenidato/farmacologia , Propilaminas/farmacologia , Inibidores da Captação Adrenérgica/farmacologia , Adulto , Cloridrato de Atomoxetina , Estimulantes do Sistema Nervoso Central/farmacologia , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Memória de Curto Prazo/classificação , Memória de Curto Prazo/fisiologia , Testes Neuropsicológicos/normas , Efeito Placebo , Recompensa , Análise e Desempenho de Tarefas , Adulto JovemRESUMO
Rosmarinus officinalis (Rosemary) demonstrates antioxidant, antidepressant, diuretic, antinociceptive and antiulcerogenic activities. The present study was designed to examine the effects of the hydroalcoholic extract of R. officinalis on the memory of male mice. The behavioral tasks employed were social recognition (SR), the Morris water maze (MWM) and an inhibitory avoidance task (IA). The treatment with 150 and 300 mg/kg of R. officinalis improved the acquisition phase of learning of a new social memory in the SR task because a decrease was observed in the duration of social investigation. In the Morris water maze, no significant effect was observed on spatial memory when the groups were compared for the time spent in the correct quadrant. In the inhibitory avoidance task, the decrease in the step-down latencies in the test session indicate that 150 mg/kg of R. officinalis improved long-term memory when administered in the consolidation phase of learning. In conclusion, the present study showed that, the hydroalcoholic extract of R. officinalis at 150 and 300 mg/kg modulated the short- and long-term memories of mice, in a social recognition and inhibitory avoidance task, respectively. This modulator effect was shown to improve learning and memory processes.
Rosmarinus officinalis L. (Alecrim) possui atividade antioxidante, antidepressiva, diurética, antinociceptiva e antiulcerogênica. O presente estudo foi delineado para investigar o efeito do extrato hidroalcoólico de R. officinallis na memória de camundongos machos. Os modelos comportamentais utilizados foram a tarefa de reconhecimento social (RS), labirinto aquático de Morris (MWM) e esquiva inibitória (EI). O tratamento com 150 e 300mg/kg de R. officinallis, mostrou ter efeito positivo na aquisição de uma nova memória social, na tarefa de reconhecimento social, mostrando redução significativa do tempo de investigação social. No labirinto aquático de Morris, não foi visto efeito significativo na memória espacial, ao comparar o tempo desprendido no quadrante correto entre os diferentes tratamentos. Na esquiva inibitória a latência de descida da plataforma, observada na sessão teste, sugere que o tratamento com a dose 150 mg/kg de R. officinallis tem um efeito positivo na memória de longo prazo, quando administrada na fase de consolidação. Conclui-se que o extrato de R. officinalis nas doses de 150 e 300 mg/kg foi capaz de modular as memórias de curto e longo prazo dos roedores nas tarefas de reconhecimento social e esquiva inibitoria, respectivamente, e esse efeito modulatório melhorou os processos de aprendizado e memória.
Assuntos
Camundongos , Rosmarinus/classificação , Extratos Aromáticos , Memória de Longo Prazo/classificação , Memória Espacial/classificação , Memória de Curto Prazo/classificação , Rosmarinus/efeitos adversosRESUMO
Working memory disturbances occur in various psychiatric disorders and play a major role for general cognitive ability in everyday life and thus social integration of the patients. In schizophrenia and bipolar disorder, working memory deficits have been found to be associated with certain genotypes and clinical symptoms. This makes them promising endophenotypes, i.e., mediators between genotype and phenotype. Furthermore recent studies indicate that the identification of selective deficits in working memory may be useful in order to define patient subgroups that are more homogenous with respect to the functional integrity or dysfunction of neural systems underlying working memory subcomponents. This scientific approach may ultimately lead to better understanding of the pathophysiologic mechanisms underlying working memory dysfunctions in psychiatric disorders and may provide clinicians with additional information for diagnostic and therapeutic decisions.