[Membrane permeability to aminazine and nonachlazine]. / Pronitsaemost' membran dlia aminazina i nonakhlazina.

Model phospholipid vesicles (liposomes) and the fluorescent probe p-terphenyl were used to study membrane permeability by phenothiazine anesthetics. The anesthetics quenched the fluorescence of the probe bound to the membrane. The extent of the quenching depended on the quenching ability to penetrate the lipid bilayer. Aminazin was able to penetrate the lipid bilayer, while nonachlazin was not. This may be accounted for by the presence of two nitrogen atoms capable of binding to H+ in the nonachlazin molecule in contrast to one nitrogen atom in the aminazin molecule.

[Nonachlazine in solution as an arresting agent in stenocardiac attacks]. / Nonakhlazin v rastvore kak sredstvo kupirovaniia pristupov stenokardii.

Nonachlazine infused in the form of a solution penetrates rapidly the blood and organs. In experiments on cats it was shown that infusion of the drug into the stomach enriches the speed of blood flow and oxyhemoglobin amount in the coronary sinus blood after 2--3 minutes. Heart oxygen consumption increases slightly. Nonachlazine solution is little toxic. As a result of pharmacological research it is recommended for removing angina pectoris attacks in patients irresponsive to nitroglycerin.

[Use of ion-exchange sorbents for determining drug preparations and their metabolites in biological fluids by high-performance liquid chromatography]. / Primenenie ionoobmennykh sorbentov pri opredelenii lekarstvennykh preparatov i ikh metabolitov v biologicheskikh zhidkostiakh metodom vysokoéffektivnoi zhidkostnoi khromatografii.

High performance liquid chromatography has acquired great importance recently for an analysis of the drugs in biological fluids of the body. Phase inversion sorbents are particularly widely used today. However, the use of ion-exchange sorbents is fairly promising for an analysis of the drugs capable of ionizing in an aqueous solution. The authors illustrate the use of the latter ones for determination in the blood, urine and saliva of man of a number of the cardiologic drugs (etmozine, nonachlazine, verapamil, prazosin, propranolol, nadolol). Ion-exchange sorbents make it possible to attain better results than inverse phase ones, since they retain the drugs selectively and do not retain the endogenous substances of lipid nature. As regards verapamil, prazosin and propranolol, the unchanged drug and polar metabolites could be determined jointly, with such a determination being not feasible with the use of phase inversion sorbents. Separation of the diastereoisomers of nadolol was achieved in the blood and urine of patients who received the drug.

[Mechanisms of action of nonachlazine]. / O nekotorykh mekhanizmakh deistviia nonakhlazina.

In animals with a ligated anterior descending left coronary artery, a single administration of nonaclazine (5 mg/kg bw) leads to a marked increase in the coronary blood flow and to an improvement in cardiovascular system function. Administration of nonachlazin for 7 days helps normalize the electrophysiological and hemodynamic characteristics and produces a beneficial effect on the myocardial blood flow and contractility. Interaction of nonaclazine with adrenergic receptors does not appear to have any decisive significance in the drug action mode.