Embryo development is impaired by sperm mitochondrial-derived ROS
Biol. Res
; 57: 5-5, 2024. ilus, graf
Article
in En
| LILACS
| ID: biblio-1550060
Responsible library:
CL1.1
ABSTRACT
BACKGROUND:
Basal energetic metabolism in sperm, particularly oxidative phosphorylation, is known to condition not only their oocyte fertilising ability, but also the subsequent embryo development. While the molecular pathways underlying these events still need to be elucidated, reactive oxygen species (ROS) could have a relevant role. We, therefore, aimed to describe the mechanisms through which mitochondrial activity can influence the first stages of embryo development.RESULTS:
We first show that embryo development is tightly influenced by both intracellular ROS and mitochondrial activity. In addition, we depict that the inhibition of mitochondrial activity dramatically decreases intracellular ROS levels. Finally, we also demonstrate that the inhibition of mitochondrial respiration positively influences sperm DNA integrity, most likely because of the depletion of intracellular ROS formation.CONCLUSION:
Collectively, the data presented in this work reveals that impairment of early embryo development may result from the accumulation of sperm DNA damage caused by mitochondrial-derived ROS.Key words
Full text:
1
Database:
LILACS
Main subject:
Semen
/
Mitochondria
Limits:
Humans
/
Male
Language:
En
Journal:
Biol. Res
Journal subject:
BIOLOGIA
Year:
2024
Type:
Article
Affiliation country:
Spain