Fibrinogen St. Gallen I (gamma 292 Gly--> Val): evidence for structural alterations causing defective polymerization and fibrinogenolysis.

Stucki, B; Schmutz, P; Schmid, L; Haeberli, A; Lämmle, B; Furlan, M

Stucki, B; Schmutz, P; Schmid, L; Haeberli, A; Lämmle, B; Furlan, M.

Affiliation

Stucki B; Central Hematology Laboratory, Inselspital, University Hospital, Bern, Switzerland.

Thromb Haemost ; 81(2): 268-74, 1999 Feb.

Article in En | MEDLINE | ID: mdl-10064005

Subject(s)

Afibrinogenemia/genetics; Amino Acid Substitution; Fibrinogens, Abnormal/genetics; Mutation, Missense; Point Mutation; Abortion, Spontaneous/etiology; Afibrinogenemia/complications; Binding Sites; Biopolymers; Blood Protein Electrophoresis; Calcium/metabolism; Calcium/pharmacology; DNA Mutational Analysis; Exons/genetics; Female; Fibrin/metabolism; Fibrin Fibrinogen Degradation Products/analysis; Fibrinogens, Abnormal/chemistry; Fibrinogens, Abnormal/isolation & purification; Fibrinolysin/metabolism; Humans; Menorrhagia/etiology; Middle Aged; Models, Molecular; Nephelometry and Turbidimetry; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Pregnancy; Protein Conformation; Thrombin Time; Uterine Hemorrhage/etiology

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Database: MEDLINE Main subject: Fibrinogens, Abnormal / Point Mutation / Amino Acid Substitution / Mutation, Missense / Afibrinogenemia Type of study: Etiology_studies / Prognostic_studies Limits: Female / Humans / Middle aged / Pregnancy Language: En Journal: Thromb Haemost Year: 1999 Type: Article Affiliation country: Switzerland

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