Abrogation of the hematological and biological activities of the interleukin-3/granulocyte-macrophage colony-stimulating factor fusion protein PIXY321 by neutralizing anti-PIXY321 antibodies in cancer patients receiving high-dose carboplatin.

Miller, L L; Korn, E L; Stevens, D S; Janik, J E; Gause, B L; Kopp, W C; Holmlund, J T; Curti, B D; Sznol, M; Smith, J W; Urba, W J; Donegan, S E; Watson, T M; Longo, D L

Miller, L L; Korn, E L; Stevens, D S; Janik, J E; Gause, B L; Kopp, W C; Holmlund, J T; Curti, B D; Sznol, M; Smith, J W; Urba, W J; Donegan, S E; Watson, T M; Longo, D L.

Affiliation

Miller LL; Frederick Cancer Research and Development Center, Biological Response Modifiers Program, National Cancer Institute, Frederick, MD, USA. langdon.l.miller@am.pnu.com

Blood ; 93(10): 3250-8, 1999 May 15.

Article in En | MEDLINE | ID: mdl-10233876

Subject(s)

Carboplatin/therapeutic use; Granulocyte-Macrophage Colony-Stimulating Factor/therapeutic use; Interleukin-3/therapeutic use; Neoplasms/drug therapy; Adult; Antibody Formation; Carboplatin/adverse effects; Cholesterol/blood; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme-Linked Immunosorbent Assay; Granulocyte-Macrophage Colony-Stimulating Factor/adverse effects; Granulocyte-Macrophage Colony-Stimulating Factor/immunology; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacokinetics; Humans; Interleukin-3/adverse effects; Interleukin-3/immunology; Interleukin-3/pharmacokinetics; Leukocyte Count/drug effects; Platelet Count/drug effects; Recombinant Fusion Proteins/adverse effects; Recombinant Fusion Proteins/pharmacokinetics; Recombinant Fusion Proteins/therapeutic use

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Database: MEDLINE Main subject: Carboplatin / Granulocyte-Macrophage Colony-Stimulating Factor / Interleukin-3 / Neoplasms Type of study: Clinical_trials Limits: Adult / Humans Language: En Journal: Blood Year: 1999 Type: Article Affiliation country: United States

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