An essential role for antibody in neutrophil and eosinophil recruitment to the cornea: B cell-deficient (microMT) mice fail to develop Th2-dependent, helminth-mediated keratitis.

Hall, L R; Lass, J H; Diaconu, E; Strine, E R; Pearlman, E

Hall, L R; Lass, J H; Diaconu, E; Strine, E R; Pearlman, E.

Affiliation

Hall LR; Division of Geographic Medicine, Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, OH 44106, USA.

J Immunol ; 163(9): 4970-5, 1999 Nov 01.

Article in En | MEDLINE | ID: mdl-10528201

Subject(s)

Antibodies, Helminth/physiology; B-Lymphocytes/pathology; Cornea/immunology; Eosinophils/immunology; Keratitis/immunology; Lymphopenia/genetics; Neutrophil Infiltration/immunology; Onchocerciasis, Ocular/immunology; Th2 Cells/immunology; Animals; Antibodies, Helminth/biosynthesis; Antigens, Helminth/administration & dosage; Antigens, Helminth/immunology; Chemotaxis, Leukocyte/genetics; Chemotaxis, Leukocyte/immunology; Cornea/pathology; Eosinophilia/immunology; Eosinophils/pathology; Immune Sera/physiology; Immunoglobulin G/biosynthesis; Immunoglobulin Heavy Chains/genetics; Immunoglobulin mu-Chains/genetics; Injections; Keratitis/genetics; Keratitis/pathology; Lymphopenia/immunology; Lymphopenia/pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration/genetics; Onchocerca volvulus/immunology; Onchocerciasis, Ocular/genetics; Onchocerciasis, Ocular/pathology; Stromal Cells/immunology; Th2 Cells/metabolism

Search on Google

Add to My VHL

XML

PubMed Links

Database: MEDLINE Main subject: Antibodies, Helminth / B-Lymphocytes / Onchocerciasis, Ocular / Th2 Cells / Cornea / Neutrophil Infiltration / Eosinophils / Keratitis / Lymphopenia Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Immunol Year: 1999 Type: Article Affiliation country: United States

Search on Google

Add to My VHL

XML

PubMed Links