Peripheral progenitor cells (CFU-GM, BFU-E, CD34) are increased in untreated chronic lymphocyte leukemia patients: stage B and C display a particularly high CD34+ cell count.
Leuk Lymphoma
; 35(5-6): 587-91, 1999 Nov.
Article
in En
| MEDLINE
| ID: mdl-10609796
ABSTRACT
No treatment has proved its efficiency in CLL. Autologous transplantation is now under consideration for the youngest patients. We assayed progenitor cells (CFU-GM, BFU-E, CD34) in the peripheral blood of 28 untreated CLL patients and found an increase of all these progenitors in CLL compared to controls. There was no statistical difference between stage A versus stages B and C for CFU-GM and BFU-E. In contrast, CD34 cells were higher in stages B and C as compared to stage A. This finding could be explained by a high number of circulating clonal cells in advanced stages of the disease.
Search on Google
Database:
MEDLINE
Main subject:
Hematopoietic Stem Cells
/
Leukemia, Lymphocytic, Chronic, B-Cell
/
Leukocyte Count
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Leuk Lymphoma
Journal subject:
HEMATOLOGIA
/
NEOPLASIAS
Year:
1999
Type:
Article
Affiliation country:
France