Changes in serum diamine oxidase activity during chemotherapy in patients with hematological malignancies.
Cancer Lett
; 147(1-2): 195-8, 1999 Dec 01.
Article
in En
| MEDLINE
| ID: mdl-10660106
ABSTRACT
Serum diamine oxidase (DAO) activity is very low, but is considered to reflect quantitative changes in small intestinal mass. Therefore, we measured DAO activity during chemotherapy in patients with hematological malignancies in order to evaluate mucosal injury. DAO activity decreased from 1-3 weeks after chemotherapy but returned to initial levels after 4 weeks. As the dosage of anti-cancer drugs increased, DAO activity decreased more, but its activity was not related to other parameters. These findings suggest that serum DAO could be used as an indicator of mucosal injury during chemotherapy.
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Database:
MEDLINE
Main subject:
Antineoplastic Combined Chemotherapy Protocols
/
Amine Oxidase (Copper-Containing)
/
Hematologic Neoplasms
/
Intestinal Mucosa
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Cancer Lett
Year:
1999
Type:
Article
Affiliation country:
Japan