The use of recombinant human G-CSF in the treatment of propylthiouracil-induced agranulocytosis.
Int J Clin Pract
; 53(5): 396-7, 1999.
Article
in En
| MEDLINE
| ID: mdl-10695110
ABSTRACT
A 43-year-old female patient with Basedow-Graves' disease developed agranulocytosis in the eighth month of propylthiouracil therapy. After discontinuing the drug, a broad spectrum antibiotic regimen plus recombinant human granulocyte colony-stimulating factor (G-CSF), a human haematopoietic growth factor, were started. Her granulocyte count returned to normal with the second dose of G-CSF, and ulcerating pharyngitis improved rapidly. We think that in patients with propylthiouracil-induced agranulocytosis, G-CSF will reduce the risk and severity of infection, and should be accepted as a part of the standard therapy.
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Database:
MEDLINE
Main subject:
Granulocyte Colony-Stimulating Factor
/
Agranulocytosis
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Int J Clin Pract
Journal subject:
MEDICINA
Year:
1999
Type:
Article
Affiliation country:
Turkey