Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest.

Niu, G; Shain, K H; Huang, M; Ravi, R; Bedi, A; Dalton, W S; Jove, R; Yu, H

Niu, G; Shain, K H; Huang, M; Ravi, R; Bedi, A; Dalton, W S; Jove, R; Yu, H.

Affiliation

Niu G; Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33613, USA.

Cancer Res ; 61(8): 3276-80, 2001 Apr 15.

Article in En | MEDLINE | ID: mdl-11309279

Subject(s)

DNA-Binding Proteins/physiology; Membrane Glycoproteins/biosynthesis; Trans-Activators/physiology; Tumor Necrosis Factor-alpha/biosynthesis; 3T3 Cells; Animals; Apoptosis/physiology; Apoptosis Regulatory Proteins; Cell Cycle/physiology; DNA, Neoplasm/metabolism; DNA-Binding Proteins/biosynthesis; DNA-Binding Proteins/genetics; Melanoma, Experimental/genetics; Melanoma, Experimental/metabolism; Melanoma, Experimental/pathology; Membrane Glycoproteins/genetics; Mice; RNA, Messenger/biosynthesis; RNA, Messenger/genetics; STAT3 Transcription Factor; Signal Transduction/physiology; Solubility; TNF-Related Apoptosis-Inducing Ligand; Trans-Activators/biosynthesis; Trans-Activators/genetics; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha/genetics

Search on Google

Add to My VHL

XML

PubMed Links

Database: MEDLINE Main subject: Membrane Glycoproteins / Trans-Activators / Tumor Necrosis Factor-alpha / DNA-Binding Proteins Limits: Animals Language: En Journal: Cancer Res Year: 2001 Type: Article Affiliation country: United States

Search on Google

Add to My VHL

XML

PubMed Links