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Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls.
Sklar, P; Schwab, S G; Williams, N M; Daly, M; Schaffner, S; Maier, W; Albus, M; Trixler, M; Eichhammer, P; Lerer, B; Hallmayer, J; Norton, N; Williams, H; Zammit, S; Cardno, A G; Jones, S; McCarthy, G; Milanova, V; Kirov, G; O'Donovan, M C; Lander, E S; Owen, M J; Wildenauer, D B.
Affiliation
  • Sklar P; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA. sklar@genome.wi.mit.edu
Nat Genet ; 28(2): 126-8, 2001 Jun.
Article in En | MEDLINE | ID: mdl-11381257
A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.
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Database: MEDLINE Main subject: Schizophrenia / Linkage Disequilibrium / Proto-Oncogene Proteins / Receptors, Cell Surface Type of study: Observational_studies / Risk_factors_studies Limits: Humans Country/Region as subject: Europa Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2001 Type: Article Affiliation country: United States
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PubMed Links

Database: MEDLINE Main subject: Schizophrenia / Linkage Disequilibrium / Proto-Oncogene Proteins / Receptors, Cell Surface Type of study: Observational_studies / Risk_factors_studies Limits: Humans Country/Region as subject: Europa Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2001 Type: Article Affiliation country: United States