The inhibition of cAMP-dependent protein kinase by full-length hepatitis C virus NS3/4A complex is due to ATP hydrolysis.

Aoubala, Mustapha; Holt, John; Clegg, Roger A; Rowlands, David J; Harris, Mark

Aoubala, Mustapha; Holt, John; Clegg, Roger A; Rowlands, David J; Harris, Mark.

Affiliation

Aoubala M; Division of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK1.
Holt J; Division of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK1.
Clegg RA; Hannah Research Institute, Ayr KA6 5HL, UK2.
Rowlands DJ; Division of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK1.
Harris M; Division of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK1.

J Gen Virol ; 82(Pt 7): 1637-1646, 2001 Jul.

Article in En | MEDLINE | ID: mdl-11413375

Subject(s)

Adenosine Triphosphate/metabolism; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors; Hepacivirus/pathogenicity; Intracellular Signaling Peptides and Proteins; Viral Nonstructural Proteins/pharmacology; Animals; Baculoviridae/genetics; COS Cells; Carrier Proteins/pharmacology; Cyclic AMP-Dependent Protein Kinases/metabolism; Cytoplasm/metabolism; Dose-Response Relationship, Drug; Genetic Vectors; Mutation; Phosphorylation/drug effects; Recombinant Proteins/pharmacology; Viral Nonstructural Proteins/biosynthesis; Viral Nonstructural Proteins/genetics

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Full text: 1 Database: MEDLINE Main subject: Adenosine Triphosphate / Viral Nonstructural Proteins / Cyclic AMP-Dependent Protein Kinases / Hepacivirus / Intracellular Signaling Peptides and Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Gen Virol Year: 2001 Type: Article

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