Increased expression and activation of poly(ADP-ribose) polymerase (PARP) contribute to retinal ganglion cell death following rat optic nerve transection.

Weise, J; Isenmann, S; Bähr, M

Weise, J; Isenmann, S; Bähr, M.

Affiliation

Weise J; Department of Neurology, University of Tübingen Medical School, D-72076 Tübingen, Germany. jweise@gwdg.de

Cell Death Differ ; 8(8): 801-7, 2001 Aug.

Article in En | MEDLINE | ID: mdl-11526433

Subject(s)

Cell Death/physiology; Gene Expression Regulation, Enzymologic/physiology; Optic Nerve/physiopathology; Poly(ADP-ribose) Polymerases/metabolism; Retinal Ganglion Cells/enzymology; Retrograde Degeneration/enzymology; Up-Regulation/physiology; Animals; Axotomy; Benzamides/pharmacology; Brain Injuries/drug therapy; Brain Injuries/enzymology; Brain Injuries/pathology; Cell Count; Cell Death/drug effects; Cell Survival/drug effects; Cell Survival/physiology; Female; Gene Expression Regulation, Enzymologic/drug effects; Necrosis; Neuroprotective Agents/pharmacology; Optic Nerve/pathology; Optic Nerve/surgery; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells/drug effects; Retinal Ganglion Cells/pathology; Retrograde Degeneration/drug therapy; Retrograde Degeneration/pathology; Up-Regulation/drug effects; Vitreous Body/drug effects; Vitreous Body/physiology

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Database: MEDLINE Main subject: Optic Nerve / Retinal Ganglion Cells / Retrograde Degeneration / Gene Expression Regulation, Enzymologic / Up-Regulation / Cell Death / Poly(ADP-ribose) Polymerases Limits: Animals Language: En Journal: Cell Death Differ Year: 2001 Type: Article Affiliation country: Germany

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