Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events.
Nat Cell Biol
; 3(9): 809-15, 2001 Sep.
Article
in En
| MEDLINE
| ID: mdl-11533660
ABSTRACT
The precise regulation of growth factor signalling is crucial to the molecular control of development in Drosophila. Post-translational modification of signalling molecules is one of the mechanisms that modulate developmental signalling specificity. We describe a new gene, fringe connection (frc), that encodes a nucleotide-sugar transporter that transfers UDP-glucuronic acid, UDP-N-acetylglucosamine and possibly UDP-xylose from the cytoplasm into the lumen of the endoplasmic reticulum/Golgi. Embryos with the frc mutation display defects in Wingless, Hedgehog and fibroblast growth factor signalling. Clonal analysis shows that fringe-dependent Notch signalling is disrupted in frc mutant tissue.
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Database:
MEDLINE
Main subject:
Signal Transduction
/
Glycosyltransferases
/
N-Acetylglucosaminyltransferases
/
Drosophila melanogaster
/
Heparitin Sulfate
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Cell Biol
Year:
2001
Type:
Article
Affiliation country:
United States