Effects of fluctuations on electrical properties of gap-junction connected cells in the turtle retina.
Neurosci Lett
; 323(1): 21-4, 2002 Apr 19.
Article
in En
| MEDLINE
| ID: mdl-11911981
ABSTRACT
Electrical properties of gap-junction connected cells (input voltage and length constant) are shown to depend strongly on fluctuations in membrane and contact conductances. This opens new possibilities and incorporates a further difficulty to the analysis of electrophysiological data, since four, instead of two, parameters (the average values and the magnitude of fluctuations of the two conductances) have to be used in fitting the experimental data. The discussion is illustrated by investigating the effects of dopamine on signal spreading in horizontal cells of turtle retina, assuming a linear cell arrangement. It is shown that while a standard fitting with the average values of the two conductances leads to the conclusion that both are equally affected by dopamine, including fluctuations allows fitting the data by varying just the average contact conductance plus the magnitude of fluctuations.
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Database:
MEDLINE
Main subject:
Retina
/
Cell Membrane
/
Gap Junctions
Limits:
Animals
Language:
En
Journal:
Neurosci Lett
Year:
2002
Type:
Article
Affiliation country:
Spain