Study on quantitative structure-toxicity relationships of benzene derivatives acting by narcosis.
Bioorg Med Chem
; 10(6): 1761-6, 2002 Jun.
Article
in En
| MEDLINE
| ID: mdl-11937334
ABSTRACT
Hydrophobicity (logP) as well as quantiative structure-toxicity relationships (QSTRs) of some benzene derivatives acting by narcosis have been established based on narcotic mechanisms of action and toxicity data to the fathead minnow, Daphnia magna and Vibrio fischeri using information-theoretic topological index (Id). Excellent results are obtained in multiparametric regression upon introduction of dummy parameters (indicator variables). Consistent increase in R(2)(A) values indicated that inspite of collinarity between Id and one of the indicator variables (I(3-6)) the proposed models are statistically significant.
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Database:
MEDLINE
Main subject:
Benzene Derivatives
/
Toxicity Tests
/
Quantitative Structure-Activity Relationship
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
Bioorg Med Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2002
Type:
Article
Affiliation country:
India