T3 blood levels and treatment outcome in depression.
Int J Psychiatry Med
; 31(4): 367-73, 2001.
Article
in En
| MEDLINE
| ID: mdl-11949735
ABSTRACT
OBJECTIVE:
We examined the correlation between the basal triiodothyronine resin uptake (T3-RU) levels in depressed subjects and the response to anti-depressant treatment.METHOD:
We treated with fluoxetine 235 outpatients meeting DSM-IV criteria for major depression. We measured T3 resin uptake (T3-RU) levels before the onset of treatment. The 17-item Hamilton Rating Scale for Depression (Ham-D-17) was administered before, during and after the eight weeks of treatment to assess changes in depressive symptoms.RESULTS:
16 patients (6.8 percent) had low T3-RU levels (range 16.5-21), and 7 patients (3.0 percent) had high T3-RU levels (range 36-38). No relationship was found between T3-RU levels and clinical improvement, defined as either total Ham-D-17 score change or Ham-D-17 score < or = 7 in the last 3 weeks of treatment, even after adjusting for baseline severity of depression.CONCLUSION:
Abnormal T3-RU levels are rather uncommon in outpatient depression and do not correlate with the response to antidepressant treatment or lack thereof.
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Database:
MEDLINE
Main subject:
Fluoxetine
/
Selective Serotonin Reuptake Inhibitors
/
Depressive Disorder
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Int J Psychiatry Med
Year:
2001
Type:
Article
Affiliation country:
United States