Evidence for anticoagulant activity and beta2-GPI accumulation in late endosomes of endothelial cells induced by anti-LBPA antibodies.

Sorice, M; Ferro, D; Misasi, R; Pittoni, V; Longo, A; Circella, A; Garofalo, T; Gradini, R; Violi, F; Gruenberg, J; Valesini, G

Sorice, M; Ferro, D; Misasi, R; Pittoni, V; Longo, A; Circella, A; Garofalo, T; Gradini, R; Violi, F; Gruenberg, J; Valesini, G.

Affiliation

Sorice M; Dipartimento di Medicina Sperimentale e Patologia, Università La Sapienza, Roma, Italy.

Thromb Haemost ; 87(4): 735-41, 2002 Apr.

Article in En | MEDLINE | ID: mdl-12008959

Subject(s)

Antibodies, Antiphospholipid/immunology; Antibodies, Monoclonal/pharmacology; Antiphospholipid Syndrome/metabolism; Autoimmune Diseases/metabolism; Blood Coagulation/drug effects; Endosomes/metabolism; Endothelium, Vascular/drug effects; Glycoproteins/metabolism; Lysophospholipids/immunology; Antibodies, Antiphospholipid/pharmacology; Antibodies, Monoclonal/immunology; Antiphospholipid Syndrome/immunology; Autoimmune Diseases/immunology; Cell Compartmentation/drug effects; Cell Line/drug effects; Cell Line/metabolism; Cell Membrane/chemistry; Dose-Response Relationship, Immunologic; Endothelium, Vascular/metabolism; Endothelium, Vascular/ultrastructure; Humans; Microscopy, Confocal; Monoglycerides; Organelles/chemistry; Partial Thromboplastin Time; Protein Transport; Prothrombin Time; beta 2-Glycoprotein I

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Database: MEDLINE Main subject: Endosomes / Autoimmune Diseases / Blood Coagulation / Endothelium, Vascular / Lysophospholipids / Glycoproteins / Antiphospholipid Syndrome / Antibodies, Antiphospholipid / Antibodies, Monoclonal Limits: Humans Language: En Journal: Thromb Haemost Year: 2002 Type: Article Affiliation country: Italy

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