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Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity.
Dhar, T G Murali; Shen, Zhongqi; Guo, Junqing; Liu, Chunjian; Watterson, Scott H; Gu, Henry H; Pitts, William J; Fleener, Catherine A; Rouleau, Katherine A; Sherbina, N Z; McIntyre, Kim W; Shuster, David J; Witmer, Mark R; Tredup, Jeffrey A; Chen, Bang-Chi; Zhao, Rulin; Bednarz, Mark S; Cheney, Daniel L; MacMaster, John F; Miller, Laura M; Berry, Karen K; Harper, Timothy W; Barrish, Joel C; Hollenbaugh, Diane L; Iwanowicz, Edwin J.
J Med Chem ; 45(11): 2127-30, 2002 May 23.
Article in En | MEDLINE | ID: mdl-12014950
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Database: MEDLINE Main subject: Oxazoles / Morpholines / Enzyme Inhibitors / IMP Dehydrogenase / Mycophenolic Acid Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2002 Type: Article
Search on Google
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Database: MEDLINE Main subject: Oxazoles / Morpholines / Enzyme Inhibitors / IMP Dehydrogenase / Mycophenolic Acid Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2002 Type: Article