Orf virus immuno-modulation and the host immune response.
Vet Immunol Immunopathol
; 87(3-4): 395-9, 2002 Sep 10.
Article
in En
| MEDLINE
| ID: mdl-12072264
ABSTRACT
Orf virus encodes a range of immuno-modulatory genes that interfere with host anti-virus immune and inflammatory effector mechanisms. The function of these reflects the pathogenesis of orf. The orf virus interferon resistance protein (OVIFNR) and virus IL-10 (vIL-10) inhibit interferon production and activity. In addition the vIL-10 suppresses inflammatory cytokine production by activated macrophages and keratinocytes. The virus GM-CSF inhibitory factor (GIF) is a novel virus protein that binds to and inhibits the biological activity of GM-CSF and IL-2. Together, these immuno-modulators target key effector mechanisms of host anti-virus immunity to allow time for virus replication in epidermal cells.
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Database:
MEDLINE
Main subject:
Poxviridae
/
Ecthyma, Contagious
Limits:
Animals
Language:
En
Journal:
Vet Immunol Immunopathol
Year:
2002
Type:
Article
Affiliation country:
United kingdom