Trophic effect of olmesartan, a novel AT1R antagonist, on spinal motor neurons in vitro and in vivo.

Iwasaki, Yasuo; Ichikawa, Yasumitsu; Igarashi, Osamu; Kinoshita, Masao; Ikeda, Ken

Iwasaki, Yasuo; Ichikawa, Yasumitsu; Igarashi, Osamu; Kinoshita, Masao; Ikeda, Ken.

Affiliation

Iwasaki Y; Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan. yaso@med.toho-u.ac.jp

Neurol Res ; 24(5): 468-72, 2002 Jul.

Article in En | MEDLINE | ID: mdl-12117316

Subject(s)

Amyotrophic Lateral Sclerosis/drug therapy; Angiotensin Receptor Antagonists; Anterior Horn Cells/drug effects; Imidazoles/pharmacology; Nerve Growth Factors/pharmacology; Neuroprotective Agents/pharmacology; Tetrazoles/pharmacology; Amyotrophic Lateral Sclerosis/metabolism; Amyotrophic Lateral Sclerosis/physiopathology; Animals; Anterior Horn Cells/metabolism; Anterior Horn Cells/pathology; Cell Survival/drug effects; Cell Survival/physiology; Choline O-Acetyltransferase/drug effects; Choline O-Acetyltransferase/metabolism; Dose-Response Relationship, Drug; Fetus; Ischemia/complications; Ischemia/drug therapy; Ischemia/prevention & control; Microcirculation/drug effects; Microcirculation/physiology; Neurites/drug effects; Neurites/metabolism; Neurites/ultrastructure; Olmesartan Medoxomil; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, Angiotensin/metabolism; Retrograde Degeneration/drug therapy; Retrograde Degeneration/etiology; Retrograde Degeneration/prevention & control; Sciatic Nerve/injuries; Sciatic Nerve/surgery

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Database: MEDLINE Main subject: Tetrazoles / Neuroprotective Agents / Angiotensin Receptor Antagonists / Amyotrophic Lateral Sclerosis / Imidazoles / Anterior Horn Cells / Nerve Growth Factors Type of study: Etiology_studies Limits: Animals Language: En Journal: Neurol Res Year: 2002 Type: Article Affiliation country: Japan

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